CAS: 32980-71-5; Perchloropyrimido[5,4-D]Pyrimidine

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CAS号7164-43-4 5-氨基乳清酸 | CAS号58-32-2 双嘧达莫 | CAS号28753-34-6 Pyrimido[5,4-d]... | CAS号7139-02-8 二氯化物 | CAS号16887-98-2 Ethanol,2,2',2'... | CAS号16908-39-7 Ethanol,2,2',2'... | CAS号68030-09-1 2-[[4,9-dichlor... | CAS号68030-10-4 2-[[2-(bis(2-hy... | CAS号89281-25-4 4,9-dichloro-3,... | CAS号93819-72-8 2,6-dichloro-4-... | CAS号57370-13-5 2,6-bis(2-hydro...

专利信息

专利号:WO-0116162-A1
优先权日:1999-08-28
标 题 :Method for producing cyclic peptidomimetics
发明人：SCHARN DIRK; GERMEROTH LOTHAR; WENSCHUH HOLGER
权利人:CHEMOTOPIX GMBH; SCHARN DIRK; GERMEROTH LOTHAR; WENSCHUH HOLGER
摘要:The invention relates to a method for the synthesis of cyclic peptides or peptidomimetics by means of sequential nucleophile substitutions on polyhalogenated aromatics. The method comprises the following steps: (i) A linear peptide or peptidomimetic with a free nucleophile functionality is reacted with the aromatic in the sense of a simple nucleophile aromatic substitution, whereby the nucleophile functionality is an alcohol, thiol or amine. (ii) The protective group of an additional nucleophile functionality is selectively split at the same peptide or peptidomimetic, whereby the released nucleophile functionality is an alcohol, thiol or amine and (iii) cyclisation is carried out by adding a tertiary amine or another base, whereby cyclisation is carried out by means of nucleophile aromatic substitution of an additional halogen atom of the halogen aromatic by the released nucleophile functionality, said halogen aromatic being bound to the peptide.

专利号:CN-106946887-A
优先权日:2017-03-24
标题 :A new process for optimizing the synthesis of dipyridamole by introducing a catalyst

专利号:CN-107782805-A
优先权日:2016-08-25
标题:A kind of key intermediate impurity HPLC analysis method of dipyridamole synthesis

专利号:CN-107782805-B
优先权日:2016-08-25
标题 :A kind of key intermediate impurity HPLC analysis method of dipyridamole synthesis

专利号:CN-119409702-A
优先权日:2024-11-13
标 题 :Synthesis method of dipyridamole key intermediate

专利号:US-5041542-A
优先权日:1988-06-03
标题 :Substituted pyrimido[5,4-d]pyrimidine nucleosides
发明人：ROBINS ROLAND K; REVANKAR GANAPATHI R; SANGHVI YOGESH S
权利人:NUCLEIC ACID RESEARCH INST
摘要:alpha and beta -ribonucleosides of substituted pyrimido[5,4-d]pyrimidines are used in treating malignant tumors in vivo. A novel synthesis for preparing these compounds and other related compounds is further disclosed.