CAS: 3154-54-9; Methyl 2-Formamidoacetate

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1212-53-9 31954-27-5 42492-57-9

上下游产品

glycine ethyl ester hydr°Chloride sodium formate acetic anhydride diazomethanemethyl 2-thioxo-1,3-dihydroimidazole-4-carboxylate is°Cyanoacetic acid methyl ester (Z)-N-formyl-α,β-dehydrotryptophan methyl ester N-formyl-glycine hydrazideN-formyl-glycine hydrazide

📜甲酸甲酯,甘胺酸甲酯置于三乙胺体系中,化学反应 72.0H,以78%的收率获得产物n-甲酰甘氨酸甲酯
参考文献:一种抗癌药物达卡巴嗪的优化合成工艺
标题:一种抗癌药物达卡巴嗪的优化合成工艺
摘要:本发明提供了一种抗癌药物达卡巴嗪的优化合成工艺,包括:甘氨酸甲酯的合成,N‑甲酰甘氨酸甲酯的合成,α‑异氰基乙酸甲酯的合成,α‑异氰基乙酰胺的合成,5‑氨基‑4‑咪唑甲酰胺的合成,达卡巴嗪的合成;甘氨酸甲酯的合成:称取甘氨酸7.5G于500Ml圆底烧瓶中,用200Ml重蒸过的甲醇做溶剂,冰浴中搅拌冷却15Min.用注射器量取22Ml二氯亚砜,慢慢滴加入反应瓶中于室温下反应过夜.室温下旋转蒸除去多余的二氯亚砜和甲醇,残留物用尽量少的热甲醇溶解,然后快速加入大量冷乙醚并将反应瓶放入冰浴中冷却;本发明通过对抗癌药物达卡巴嗪的合成工艺的改进,具有合成线路合理,原料廉价,反应条件温和,总收率高的优点,从而有效的解决了现有技术中出现问题和不足.

专利信息

专利号:US-5521179-A
优先权日:1991-04-18
标题 :Heterocyclic amides
发明人：BERNSTEIN PETER R; SHAW ANDREW; THOMAS ROYSTON M; WARNER PETER; WOLANIN DONALD J
权利人:ZENECA LTD
摘要:The present invention relates to certain novel heterocyclic amides which are 1-pyridylacetamide compounds of formula I, set out herein, which are inhibitors of human leukocyte elastase (HLE), also known as human neutrophil elastase (HNE), making them useful whenever such inhibition is desired, such as for research tools in pharmacological, diagnostic and related studies and in the treatment of diseases in mammals in which HLE is implicated. The invention also includes intermediates useful in the synthesis of these heterocyclic amides, processes for preparing the heterocyclic amides, pharmaceutical compositions containing such heterocyclic amides and methods for their use.

专利号:US-8933018-B2
优先权日:2011-02-07
标题 :Boron containing polybasic bacterial efflux pump inhibitors and therapeutic uses thereof
发明人：GLINKA TOMASZ; HIGUCHI ROBERT; HECKER SCOTT; EASTMAN BRIAN; RODNY OLGA
权利人:GLINKA TOMASZ; HIGUCHI ROBERT; HECKER SCOTT; EASTMAN BRIAN; RODNY OLGA; REMPEX PHARMACEUTICALS INC
摘要:Disclosed herein are polybasic bacterial efflux pump inhibitors containing boronic acid functionality and their methods of synthesis, methods of use, and pharmaceutical compositions. Some embodiments include methods of treating or preventing a bacterial infection by co-administering to a subject infected with bacteria or at risk of infection with bacteria the efflux pump inhibitor with another anti-bacterial agent.

专利号:US-5523410-A
优先权日:1992-07-02
标 题 :Intermediate for synthesis and production of amino acid derivative
发明人：KAGARA KOOJI; KAWAI NOBUTAKA; MACHIYA KOJI; FURUTERA TETSUO; NAKAMURA TAKASHI; OMORI HIROKI
权利人:FUJISAWA PHARMACEUTICAL CO
摘要:The present invention relates to synthetic intermediates useful for preparing amino acid derivatives possessing renin-inhibitory activity, and to processes for preparing the amino acid derivatives using the synthetic intermediates.

专利号:EP-0648747-A1
优先权日:1992-07-02
标题:Novel intermediate for synthesis and production of amino acid derivative

专利号:CN-110305067-A
优先权日:2019-06-12
标 题 :An optimized synthesis process of an anticancer drug dacarbazine