CAS: 252742-72-6; 3-(Chloromethyl)-1H-1,2,4-Triazol-5(4H)-One

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CAS号563-41-7 盐酸氨基脲 | CAS号74974-54-2 1,1,1-三甲氧基-2-氯乙烷 | CAS号24021-90-7 5-hydroxymethyl... | CAS号172822-29-6 ENT-阿瑞匹坦 | CAS号170729-80-3 阿瑞吡坦 | CAS号1148113-53-4 阿瑞吡坦相关物质A | CAS号83160-78-5 5-(氨基甲基)-1,2-二氢...

2-氯-1,1,1-三甲氧基乙烷 以 甲醇,甲苯 用作溶剂,化学反应生成3-氯甲基-1,2,4-三唑啉-5-酮
参考文献:Process For The Preparation Of 1,2,4-Triazolin-5-One Derivatives
标题:Process For The Preparation Of 1,2,4-Triazolin-5-One Derivatives
摘要:本发明涉及一种制备式(I)化合物的方法,其中r代表氢,C1-10烷基,卤代c1-10烷基或芳基;这些化合物在制备式(A)吗啡啶衍生物中起中间体作用.式(A)化合物可用作治疗剂.

专利信息

专利号:US-6407255-B2
优先权日:1998-06-16
标题:Chemical synthesis of 1,2,4-triazolinone derivative
发明人：COTTRELL IAN FRANK; DOLLING ULF H; HANDS DAVID; WILSON ROBERT DARRIN
权利人:MERCK SHARP & DOHME
摘要:The present invention relates to a process for the preparation of morpholine derivatives of formula (I) which are useful as a therapeutic agents.

专利号:US-8940890-B2
优先权日:2010-05-24
标 题:Preparation method of 5-[[2(R)-[1(R)-[3,5-bis(trifluoromethyl) phenyl]ethoxy]-3(S)-4-fluorophenyl-4-morpholinyl]methyl]-1,2-dihydro-3H-1,2,4-triazole-3-one
发明人：JI JIANXIN; ZHANG QIANG; DU FENGTIAN; JIN YI; ZHANG TAO; GUO NA; YAN XIAOWEI; YANG YONGRONGN; LI BOGANG
权利人:JI JIANXIN; ZHANG QIANG; DU FENGTIAN; JIN YI; ZHANG TAO; GUO NA; YAN XIAOWEI; YANG YONGRONGN; LI BOGANG; CHENGDU DI AO PHARMACEUTICAL GROUP CO LTD
摘要:Disclosed is a synthesis method of a compound of formula 1,5-[[2(R)-[1(R)-[3,5-bis(trifluoromethyl)phenyl]ethoxyl]-3(S)-4-fluorophenyl-4-morpholinyl]methyl]-1,2-dihydro-3H-1,2,4-triazole-3-one (i.e. aprepitant), which comprises cyclizing a compound of formula 4 in a solvent, wherein R is C 1 -C 5 alkyl. The intermediate for preparing aprepitant is also disclosed. The present method is especially suitable for industrial production of aprepitant.

专利号:JP-2010195808-A
优先权日:1998-06-16
标 题 :Chemical synthesis of morpholine derivatives

专利号:JP-2002518388-A
优先权日:1998-06-16
标题:Chemical synthesis of morpholine derivatives

专利号:EP-1087966-A1
优先权日:1998-06-16
标题 :Chemical synthesis of morpholine derivatives

专利号:WO-9965900-A1
优先权日:1998-06-16
标题 :Chemical synthesis of morpholine derivatives