三苯基硼烷置于palladium Diacetate体系中,用 四氢呋喃,水,甲苯 用作溶剂,化学反应 20.0H,反应生成3-氨基联苯 参考文献:Subtle Reactivities Of Boron And Aluminum Complexes With Amino-Linked N-Heterocyclic Carbene Ligation 标题:Subtle Reactivities Of Boron And Aluminum Complexes With Amino-Linked N-Heterocyclic Carbene Ligation 摘要:This Paper Describes The Synthesis And Characterization Of Trimethylaluminum (2A),Dimethylaluminum (3A),And Triphenylboron Complexes (7) Supported By Functional Amine-Linked Nhc Ligands. The Chemical Reactivity Studies With Carbodiimide And Isocyanate Were Preformed With 2A And 3A,Illustrating The Noninnocent Nature In Al-Carbene Bonding. However,The Boron-Carbene Interaction Is Quite Robust Against Addition Of These Substrates Even At Higher Temperature Conditions. The Subtle Difference In Chemical Reactivity Between Aluminum And Boron Is Attributed From The Metal-Carbene Bond Covalency. Development Of The Catalytic Method For Suzuki-Miyaura Coupling Utilizing Triphenylboron Reagent Supported By Amino-Nhc Is Also Presented. Doi:10.1021/om200878E
专利信息
专利号:US-9890126-B2 优先权日:2012-04-24 标 题:Synthesis of novel inhibitors of isoprenoid biosynthesis (ISPF) 发明人:HAGEN TIMOTHY J; ZHANG ZHENG; LAZOWSKI ZACHARY; CLARE MICHAEL; BEGLEY DARREN W 权利人:UNIV NORTHERN ILLINOIS BOARD OF TRUSTEES; BERYLLIUM DISCOVERY CORP 摘要:Antibacterial and antimalarial IspF inhibitor compounds and compositions are described. Methods include administering described compounds and compositions to treat bacterial or parasitic infections and to inhibit parasite or bacterial growth.
专利号:WO-9948868-A9 优先权日:1998-03-26 标 题 :Heterocyclic classes of compounds for the modulating tyrosine protein kinase 发明人:FONG ANNIE; HANNAH ALISON; HARRIS G DAVIS; HIRTH PETER; HUBBARD STEVEN R; LANGECKER PETER; LIANG CONGXIN; MCMAHON GERALD; MOHAMMADI MOOSA; SCHLESSINGER JOSEPH; SHAWVER LAURA K; SUN LI; TANG PENG C; ULLRICH AXEL 权利人:SUGEN INC; UNIV NEW YORK; MAX PLANCK INST FUR BIOCHEMIE; FONG ANNIE; HANNAH ALISON; HARRIS G DAVIS; HIRTH PETER; HUBBARD STEVEN R; LANGECKER PETER; LIANG CONGXIN; MCMAHON GERALD; MOHAMMADI MOOSA; SCHLESSINGER JOSEPH; SHAWVER LAURA K; SUN LI; TANG PENG C; ULLRICH AXEL 摘要:The invention relates to certain indolinone-based and pyrazolylamide-based compounds, their method of synthesis, and combinatorial libraries consisting of the compounds. The invention also relates to methods of modulating the function of protein kinases using these compounds and methods of treating diseases by modulating the function of protein kinases and related signal transduction pathways.
专利号:WO-2009143405-A2 优先权日:2008-05-22 标 题:Synthesis of graphene sheets and nanoparticle composites comprising same
专利号:US-6054464-A 优先权日:1996-02-23 标题:Azabicyclic esters of carbamic acids useful in therapy 发明人:MACOR JOHN; WU EDWIN 权利人:ASTRA AB 摘要:A compound of formula ##STR1## X is O or S; Y is O or S; G and D are independently nitrogen or carbon with the proviso that no more than one of G, D, or E is nitrogen; E is N or C--R 4 ; R 1 is hydrogen or methyl; R 2 is hydrogen or fluoro; R 3 is hydrogen, halogen, C 1 to C 3 alkyl, --OR 5 , --CN, --CONH 2 , --CO 2 R 5 , --NR 5 R 6 or phenyl optionally substituted with one to three of the following substituents: halogen, C 1 to C 3 alkyl, --NO 2 , --CN, or --OCH 3 ; R 4 is hydrogen, halogen, C 1 to C 3 alkyl, --OR 5 , --CN, --CONH 2 , --CO 2 R 5 , --NR 5 R 6 or phenyl optionally substituted with one to three of the following substituents: halogen, C 1 to C 3 alkyl, --NO 2 , --CN, or --OCH 3 ; n or R 2 and R 3 or R 3 and R 4 may together represent a fused phenyl ring optionally substituted with one or two of the following substituents: halogen, C 1 to C 3 alkyl, --NO 2 , --CN, or --OCH 3 ; R 5 and R 6 are independently hydrogen or C 1 to C 3 alkyl; n or an enantiomer thereof, and pharmaceutically acceptable salts thereof, processes for preparing the, compositions containing them, and their use in therapy, especially in the treatment or prophylaxis of psychotic disorders and intellectual impairment disorders, as well as intermediates and use of intermediates in synthesis.
专利号:CN-102125875-B 优先权日:2011-01-20 标 题 :Application of ferroceneimine cyclopalladium-phosphine adducts in the synthesis of unsymmetrical biaryl compounds
专利号:US-2015175582-A1 优先权日:2012-04-24 标 题:Design and synthesis of novel inhibitors of isoprenoid biosynthesis
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合成参考文献
摘要:F. Kieffer and P. Rumpf. Compt. Rend. 230, 1874 (1950). 参考文献:10.1016/j.talanta.2007.08.039 摘要:Barek J, Jandová K, Pecková K, Zima J. Voltammetric determination of aminobiphenyls at a boron-doped nanocrystalline diamond film electrode. Talanta. 2007 Dec 15;74(3):421–6. doi: 10.1016/j.talanta.2007.08.039.