CAS: 2243-47-2; [1,1'-Biphenyl]-3-Amine

该化合物是一种含有分子式C12H11N的芳香剂化合物,其基芯在3号位置上以氨基氨基组取代,作为有机合成的多用途中间体,特别是在染料,药品和农用化学品生产方面,其双苯结构具有稳定性和回动性,使其对组合反应和功能组变具有价值;氨基组增强了其作为进一步衍生前体的效用. 3-Aminobenty由于潜在的毒性,通常在受控条件下处理,其纯度很高,以确保研究和工业应用的一致性;建议适当储存和处理以保持其完整性.

结构式图片

欧盟法规

ECHA物质C&L通报

上下游产品

CAS号2113-58-8 3-硝基联苯 | CAS号591-19-5 3-溴苯胺 | CAS号98-80-6 苯硼酸 | CAS号2996-92-1 苯基三甲氧基硅烷 | CAS号108-42-9 间氯苯胺 | CAS号853955-69-8 2-(Dimethylphen... | CAS号626-01-7 3-碘苯胺 | CAS号24388-23-6 苯硼酸频呐醇酯 | CAS号109221-88-7 [1,1'-联苯]-3-基肼盐酸盐 | CAS号2113-58-8 3-硝基联苯 | CAS号59080-33-0 2,4,6-三溴联苯 | CAS号53592-10-2 2,4-二溴联苯 | CAS号580-51-8 间羟基联苯 | CAS号115761-61-0 1-(3-联苯)哌嗪 | CAS号31477-46-0 1-methylsulfany... | CAS号198275-79-5 N-苯基-3-联苯胺 | CAS号20442-79-9 3-碘联苯 | CAS号1166-18-3 3,3-二苯基联苯

合成工艺路线路线简述

  • 合成目标产物 3-Aminobiphenyl 主要起始原料 3-Chloroaniline And Phenylboronic Acid
  • (文献来源)合成步骤主要原料 3-Chloroaniline 和 Phenylboronic Acid
三苯基硼烷置于palladium Diacetate体系中,用 四氢呋喃,水,甲苯 用作溶剂,化学反应 20.0H,反应生成3-氨基联苯
参考文献:Subtle Reactivities Of Boron And Aluminum Complexes With Amino-Linked N-Heterocyclic Carbene Ligation
标题:Subtle Reactivities Of Boron And Aluminum Complexes With Amino-Linked N-Heterocyclic Carbene Ligation
摘要:This Paper Describes The Synthesis And Characterization Of Trimethylaluminum (2A),Dimethylaluminum (3A),And Triphenylboron Complexes (7) Supported By Functional Amine-Linked Nhc Ligands. The Chemical Reactivity Studies With Carbodiimide And Isocyanate Were Preformed With 2A And 3A,Illustrating The Noninnocent Nature In Al-Carbene Bonding. However,The Boron-Carbene Interaction Is Quite Robust Against Addition Of These Substrates Even At Higher Temperature Conditions. The Subtle Difference In Chemical Reactivity Between Aluminum And Boron Is Attributed From The Metal-Carbene Bond Covalency. Development Of The Catalytic Method For Suzuki-Miyaura Coupling Utilizing Triphenylboron Reagent Supported By Amino-Nhc Is Also Presented.
Doi:10.1021/om200878E

专利信息


专利号:US-9890126-B2
优先权日:2012-04-24
标 题:Synthesis of novel inhibitors of isoprenoid biosynthesis (ISPF)
发明人:HAGEN TIMOTHY J; ZHANG ZHENG; LAZOWSKI ZACHARY; CLARE MICHAEL; BEGLEY DARREN W
权利人:UNIV NORTHERN ILLINOIS BOARD OF TRUSTEES; BERYLLIUM DISCOVERY CORP
摘要:Antibacterial and antimalarial IspF inhibitor compounds and compositions are described. Methods include administering described compounds and compositions to treat bacterial or parasitic infections and to inhibit parasite or bacterial growth.

专利号:WO-9948868-A9
优先权日:1998-03-26
标 题 :Heterocyclic classes of compounds for the modulating tyrosine protein kinase
发明人:FONG ANNIE; HANNAH ALISON; HARRIS G DAVIS; HIRTH PETER; HUBBARD STEVEN R; LANGECKER PETER; LIANG CONGXIN; MCMAHON GERALD; MOHAMMADI MOOSA; SCHLESSINGER JOSEPH; SHAWVER LAURA K; SUN LI; TANG PENG C; ULLRICH AXEL
权利人:SUGEN INC; UNIV NEW YORK; MAX PLANCK INST FUR BIOCHEMIE; FONG ANNIE; HANNAH ALISON; HARRIS G DAVIS; HIRTH PETER; HUBBARD STEVEN R; LANGECKER PETER; LIANG CONGXIN; MCMAHON GERALD; MOHAMMADI MOOSA; SCHLESSINGER JOSEPH; SHAWVER LAURA K; SUN LI; TANG PENG C; ULLRICH AXEL
摘要:The invention relates to certain indolinone-based and pyrazolylamide-based compounds, their method of synthesis, and combinatorial libraries consisting of the compounds. The invention also relates to methods of modulating the function of protein kinases using these compounds and methods of treating diseases by modulating the function of protein kinases and related signal transduction pathways.

专利号:WO-2009143405-A2
优先权日:2008-05-22
标 题:Synthesis of graphene sheets and nanoparticle composites comprising same

专利号:US-6054464-A
优先权日:1996-02-23
标题:Azabicyclic esters of carbamic acids useful in therapy
发明人:MACOR JOHN; WU EDWIN
权利人:ASTRA AB
摘要:A compound of formula ##STR1## X is O or S; Y is O or S; G and D are independently nitrogen or carbon with the proviso that no more than one of G, D, or E is nitrogen; E is N or C--R 4 ; R 1 is hydrogen or methyl; R 2 is hydrogen or fluoro; R 3 is hydrogen, halogen, C 1 to C 3 alkyl, --OR 5 , --CN, --CONH 2 , --CO 2 R 5 , --NR 5 R 6 or phenyl optionally substituted with one to three of the following substituents: halogen, C 1 to C 3 alkyl, --NO 2 , --CN, or --OCH 3 ; R 4 is hydrogen, halogen, C 1 to C 3 alkyl, --OR 5 , --CN, --CONH 2 , --CO 2 R 5 , --NR 5 R 6 or phenyl optionally substituted with one to three of the following substituents: halogen, C 1 to C 3 alkyl, --NO 2 , --CN, or --OCH 3 ; n or R 2 and R 3 or R 3 and R 4 may together represent a fused phenyl ring optionally substituted with one or two of the following substituents: halogen, C 1 to C 3 alkyl, --NO 2 , --CN, or --OCH 3 ; R 5 and R 6 are independently hydrogen or C 1 to C 3 alkyl; n or an enantiomer thereof, and pharmaceutically acceptable salts thereof, processes for preparing the, compositions containing them, and their use in therapy, especially in the treatment or prophylaxis of psychotic disorders and intellectual impairment disorders, as well as intermediates and use of intermediates in synthesis.

专利号:CN-102125875-B
优先权日:2011-01-20
标 题 :Application of ferroceneimine cyclopalladium-phosphine adducts in the synthesis of unsymmetrical biaryl compounds

专利号:US-2015175582-A1
优先权日:2012-04-24
标 题:Design and synthesis of novel inhibitors of isoprenoid biosynthesis
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主要参考文献

[参考文献]: G Ronco, Et Al. Haemoglobin Adducts Formed By Aromatic Amines In Smokers: Sources Of Inter-Individual Variability. Br J Cancer. 1990 Apr;61(4):534-7.
[参考文献]: J Esteban Castelao, Et Al. Carotenoids/vitamin C And Smoking-Related Bladder Cancer. Int J Cancer. 2004 Jun 20;110(3):417-23.
[参考文献]: M Kajbaf, Et Al. Metabolism Of [参考文献]: M Maclure, Et Al. Elevated Blood Levels Of Carcinogens In Passive Smokers. Am J Public Health. 1989 Oct;79(10):1381-4.
[参考文献]: M S Bryant, Et Al. Haemoglobin Adducts Of Aromatic Amines In People Exposed To Cigarette Smoke. Iarc Sci Publ. 1988:(89):133-6.

合成参考文献


摘要:F. Kieffer and P. Rumpf. Compt. Rend. 230, 1874 (1950).
参考文献:10.1016/j.talanta.2007.08.039
摘要:Barek J, Jandová K, Pecková K, Zima J. Voltammetric determination of aminobiphenyls at a boron-doped nanocrystalline diamond film electrode. Talanta. 2007 Dec 15;74(3):421–6. doi: 10.1016/j.talanta.2007.08.039.
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