CAS: 22395-22-8; 7-Methoxy-2-Phenyl-4H-Chromen-4-One

该化合物是一种合成的食草类衍生物,其特点是在弗拉夫酮主骨的7个位置上存在一种甲氧基,这种改变增强了其稳定性和影响其生物活动,使其成为药理学和生物化学研究的宝贵化合物,其结构允许与酶和受体进行选择性互动,特别是涉及氧化性压力和炎热途径的受体.复合物表明有机溶剂的溶解性比非代用品的食草酮有所改善,促进了其在实验应用中的使用.研究人员利用7-Methoxyflavone作为参考标准,或作为更复杂的食草类分子合成的中间体.其定义明确的化学特性支持了分析和机械研究的可复制结果.

结构式图片

物理性质

MSDS等安全信息

上下游产品

tetrachloromethane N-Bromosuccinimide 7-methoxyflavanone dibenzoyl peroxide 7-methoxy-2-phenyl-chromene-4-thione 4-(p-benzyloxyphenyl)-4-hydroxy-7-methoxy-2-phenyl-4H-chromene 5-Methoxy-7a-phenyl-1a,7a-dihydro-1H-7-oxa-cyclopropa[b]naphthalen-2-one 4'-methoxy-2'-hydroxyl-dihydr°Chalcone

合成工艺路线路线简述

  • 合成目标产物 7-Methoxyflavone 主要起始原料 Paeonol And Benzaldehyde
  • (文献来源)合成步骤主要原料 Paeonol 和 Benzaldehyde
📜丹皮酚置于盐酸,1,10-菲罗啉,氧气,Palladium Diacetate体系中,用 二氯甲烷,水,N,N-二甲基甲酰胺 用作溶剂,化学反应 25.08H,反应生成7-甲氧基黄酮
参考文献:通过区域选择性钯催化的氧化heck反应,可轻松实现黄酮和新黄酮骨架的合成.
标题:通过区域选择性钯催化的氧化heck反应,可轻松实现黄酮和新黄酮骨架的合成.
摘要:设计了一种简单,原子经济的无碱钯催化香豆素和色农酮的区域选择性直接芳基化反应.该方案与多种供电子和吸电子取代基兼容,并允许构建各种生物学上重要的黄酮和新黄酮骨架.
Doi:10.1039/c2Cc18150A

海关参考信息

专利信息


专利号:WO-2020032913-A1
优先权日:2018-08-04
标题:Process for synthesis of oroxylin a
发明人：MAJEED MUHAMMED; NAGABHUSHANAM KALYANAM; RAMANUJAM RAJENDRAN; HEMANTHA HOSAHALLI
权利人:MAJEED MUHAMMED; NAGABHUSHANAM KALYANAM; RAMANUJAM RAJENDRAN; HEMANTHA HOSAHALLI PRABHAKARA
摘要:Disclosed is a novel, simple, scalable and environment friendly process for the synthesis of Oroxylin A from Baicalin. Baicalm is esterified to obtain a methyl ester which is further selectively methylated to provide Oroxylin A gluciironide methyl ester which on de- glycosylation results in the formation of Oroxylin A.

专利号:US-10407401-B1
优先权日:2018-08-04
标题 :Process for synthesis of Oroxylin A
发明人：MAJEED MUHAMMED; NAGABHUSHANAM KALYANAM; RAMANUJAM RAJENDRAN; HEMANTHA HOSAHALLI PRABHAKARA
权利人:MAJEED MUHAMMED; NAGABHUSHANAM KALYANAM; RAMANUJAM RAJENDRAN; HEMANTHA HOSAHALLI PRABHAKARA; SAMI LABS LTD
摘要:Disclosed is a novel, simple, scalable and environment friendly process for the synthesis of Oroxylin A from Baicalin. Baicalin is esterified to obtain a methyl ester which is further selectively methylated to provide Oroxylin A glucuronide methyl ester which on de-glycosylation results in the formation of Oroxylin A.

专利号:WO-2025125811-A1
优先权日:2023-12-12
标题:Heterocyclic compounds and their use for the treatment of neurological disorders
发明人：PLOWRIGHT ALLEYN THOMAS; PFEIFFER THOMAS; MÄRCHER-RØRSTED EMIL; DUCKWORTH EDWARD JOSEPH
权利人:ONTRACK THERAPEUTICS LTD
摘要:The present invention relates to novel synthetic compounds of Formula (I) and (II) related to naturally occurring flavonoids such as 7,8-dihydroxyflavone (7,8-DHF). The invention further relates to the method of synthesis, the use of these compounds as research tools and their use as pharmaceuticals.

专利号:CN-105294627-A
优先权日:2015-11-04
标题:A method for one-step synthesis of flavonoids catalyzed by 1,3-dialkylimidazolium oxometalates

专利号:CN-105294627-B
优先权日:2015-11-04
标 题:A method for one-step synthesis of flavonoids catalyzed by 1,3-dialkylimidazolium oxometalates

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主要参考文献


1: Aksoy M, Öztekin A. Using of group-based selected flavonoids as alternative inhibitors for potato polyphenol oxidase. J Food Biochem. 2021 Mar
9:e13700. doi: 10.1111/jfbc.13700. Epub ahead of print. 72(3):385-395. doi: 10.1111/jphp.13219. Epub 2019 Dec 22. 85(3):1392-1400. doi: 10.1021/acs.joc.9b02358. Epub 2019 Nov 8.

合成参考文献


摘要:Dong, X.; Liu , H., Science of Synthesis Knowledge Updates, (2019) 3, .
摘要:Dong, X.; Liu , H., Science of Synthesis Knowledge Updates, (2019) 3, .
摘要:Dong, X.; Liu , H., Science of Synthesis Knowledge Updates, (2019) 3, .
摘要:Dong, X.; Liu , H., Science of Synthesis Knowledge Updates, (2019) 3, .
摘要:Dong, X.; Liu , H., Science of Synthesis Knowledge Updates, (2019) 3, .
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