CAS: 14379-56-7; (S)-2-Dodecanamido-3-Hydroxypropanoic Acid

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n-dodecanoyl chloride L-serin N-succinimidyl laurate lauric acidL-serin

📜L-丝氨酸置于碳酸氢钠体系中,用 四氢呋喃 用作溶剂,化学反应生成N-十二碳酰-L-丝氨酸
参考文献:月桂酰氨基酸与洗涤剂混合胶束的催化作用
标题:月桂酰氨基酸与洗涤剂混合胶束的催化作用
摘要:研究了月桂酰氨基酸 (Lauam) 和洗涤剂的混合胶束对乙酸对硝基苯酯水解的催化作用.用于合成 Lauam 的氨基酸是甘氨酸,丝氨酸,组氨酸,酪氨酸,赖氨酸和精氨酸.使用十六烷基三甲基溴化铵(ctab),聚氧乙烯十二烷基醚(c12E6)和十二烷基硫酸钠(sds)制备含有lauam的混合胶束.在使用的洗涤剂中,只有 Ctab 显着增强了 Lauam 的催化活性.提出了反应方案,并从动力学数据估计了 Lauam 催化活性的速率常数.还研究了ph的影响.在本研究的基础上讨论了催化作用的机理.
Doi:10.1246/bcsj.49.719

专利信息

专利号:US-6090250-A
优先权日:1993-09-20
标题 :Chiral surfactants and methods for their use in chiral separations
发明人：MAZZEO JEFFREY R; GROVER EDWARD R; SWARTZ MICHAEL E; MERION MICHAEL; PETERSEN JOHN S
权利人:WATERS INVESTMENTS LTD
摘要:PCT No. PCT/US94/10655 Sec. 371 Date Mar. 20, 1996 Sec. 102(e) Date Mar. 20, 1996 PCT Filed Sep. 20, 1994 PCT Pub. No. WO95/08529 PCT Pub. Date Mar. 30, 1995Chiral surfactants, methods for their synthesis and use, and apparatus designed to facilitate chiral separations using nucellar capillary electrophoresis is disclosed. A chiral surfactant having the general formula: is described, R1 is the hydrophobic tail, Y-A-X is the linker, the brackets define a chiral center, and the hydrophilic head group is Z. All the various components may potentiate the enantioselectivity of the chiral surfactant. The capillary electrophoresis (CE) system includes a narrow diameter capillary, a high voltage power supply, an electrolyte reservoir at each end of the capillary, a means for injecting a sample, and a detector. Chiral surfactants are dissolved in the electrolyte above their critical micelle concentration (cmc), resulting in the formation of chiral micelles. The electrolyte reservoirs and capillary tube are filled with the electrolyte. A sample containing a mixture of enantiomers is then injected into the capillary, and a high voltage potential is applied across the capillary. The sample components migrate through the capillary due to the influence of the applied electric field. An example separation of the four sereoisomers of aspartame is shown.