CAS: 141626-36-0; N-(2-Butyl-3-(4-(3-(Dibutylamino)Propoxy)Benzoyl)Benzofuran-5-yl)Methanesulfonamide

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CAS号111-92-2 二正丁胺 | CAS号1912-32-9 甲烷磺酸丁酯 | CAS号627040-50-0 N-(3-(4-bromoph...

4-(3-Chloropropoxy)Benzoyl Chloride置于四丁基溴化铵,四氯化锡,碳酸氢钠,三乙胺,甲胺,Potassium Iodide体系中,用 二氯甲烷,水,N,N-二甲基甲酰胺,异丙醇,甲苯 用作溶剂,化学反应 18.5H,反应生成决奈达隆
参考文献:纯化的纯决奈达隆盐酸盐的改进的可扩展路线
标题:纯化的纯决奈达隆盐酸盐的改进的可扩展路线
摘要:通过2-(-2-丁基-1-苯并呋喃-5-基)-1 H-异吲哚-1,3(2 H)二酮(12)的friedel-Craft酰化反应,有效合成可得的决奈达隆盐酸盐(2)通过使用伊顿试剂代替诸如alcl 3或sncl 4的有害和有毒金属卤化物催化剂,已经开发出了具有高收率和高纯度的4-(3-氯丙氧基)苯甲酸(13).
Doi:10.1021/op300017V

专利信息

专利号:US-11897827-B1
优先权日:2022-11-22
标 题 :Carbon isotope exchange mediated by vanadium complexes
发明人：BUKHRYAKOV KONSTANTIN
权利人:BUKHRYAKOV KONSTANTIN; THE FLORIDA INTERNATIONAL UNIV BOARD OF TRUSTEES
摘要:The subject invention provides catalytical compounds/complexes, compositions comprising such compound/complex, synthesis of the compounds/complexes, and methods of using such compounds/complexes as catalysts in, for example, carbon isotope exchange (CIE) on target bioactive molecules. Methods that allow CIE directly on drug candidates are of great importance to chemistry, biology, and medicine. Especially valuable are catalytic procedures that rely on a limited collection of available labeled materials. The instant method comprises converting a methyl group to terminal â•?CH2 utilizing transfer dehydrogenation catalysts to enable V-based olefin metathesis, followed by a hydrogenation step. The one-pot strategy allows the formal methylation/demethylation sequence and can be applied to an assortment of alkyl-containing compounds.

专利号:US-2012108828-A1
优先权日:2010-09-09
标题 :Synthesis of dronedarone and salts thereof
发明人：SATHE DHANANJAY GOVIND; PATIL SAMADHAN DAULAT; GAIKWAD UMESH DILIP; RAO MANTRIPRAGADA NARAYANA; SHINDE AJIT BHASKAR
权利人:SATHE DHANANJAY GOVIND; PATIL SAMADHAN DAULAT; GAIKWAD UMESH DILIP; RAO MANTRIPRAGADA NARAYANA; SHINDE AJIT BHASKAR; USV LTD B S D MARG
摘要:The present invention relates to a process for preparation of Dronedarone or pharmaceutically acceptable salts thereof. More particularly, the present invention provides a process for preparation of Dronedarone hydrochloride, without the isolation of Dronedarone base.

专利号:US-8536350-B2
优先权日:2010-02-23
标 题:Process for the manufacture of dronedarone
发明人：SADA MARA; NARDI ANTONIO; MAIORANA STEFANO
权利人:SADA MARA; NARDI ANTONIO; MAIORANA STEFANO; LABORATORIO CHIMICO INT SPA
摘要:The invention relates to a new process for the preparation of dronedarone and its salts, in particular a synthesis process which allows said compound and its salts to be obtained with good yields, high purity and in an industrially expedient manner; the invention also concerns a new synthesis intermediate.

专利号:US-9550000-B2
优先权日:2011-09-09
标题 :Compositions, methods, and systems for the synthesis and use of imaging agents
发明人：ROBINSON SIMON P; YU MING
权利人:ROBINSON SIMON P; YU MING; LANTHEUS MEDICAL IMAGING INC
摘要:The present invention relates to systems, compositions, and methods for the synthesis and use of imaging agents, or precursors thereof. An imaging agent precursor may be converted to an imaging agent using the methods described herein. In some cases, the imaging agent is enriched in 18 F. In some cases, an imaging agent may be used to image an area of interest in a subject, including, but not limited to, the heart, cardiovascular system, cardiac vessels, brain, and other organs. In some embodiments, methods and compositions for assessing perfusion and innervation mismatch in a portion of a subject are provided.

专利号:US-6828448-B2
优先权日:2000-12-11
标 题:Methanesulphonamido-benzofuran, preparation method and use thereof as synthesis intermediate
发明人：FINO NOEL; LEROY CORINNE
权利人:SANOFI SYNTHELABO
摘要:The invention relates to 2-butyl-5-(methanesulfonamido)benzofuran, its preparation and its use. n This compound is a synthesis intermediate, in particular for the preparation of dronedarone.

专利号:US-8779201-B2
优先权日:2007-10-02
标题 :Process for preparing benzofurans
发明人：EKLUND LARS
权利人:CAMBREX KARLSKOGA AB
摘要:There is provided a process for the preparation of a compound of formula (I), wherein R 1 , R 2 , R 3 , R 4 , X and Y are as described in the description. Such compounds may, for example, be useful intermediates in the synthesis of drugs such as Dronedarone.