CAS: 13007-85-7; Sodium (2R,3R,4S,5R,6R)-2,3,4,5,6,7-Hexahydroxyheptanoate

专利信息

专利号:WO-03086476-A1
优先权日:2002-04-08
标 题 :Technetium-labeled rotenone derivatives, and methods of use thereof
发明人：BABICH JOHN W; MARESCA KEVIN P
权利人:BIOSTREAM INC; BABICH JOHN W; MARESCA KEVIN P
摘要:One aspect of the present invention relates to Tc-99m-labeled rotenone derivatives. These derivatives are useful, for example, as myocardial blood flow imaging agents. Reported herein are the synthesis, radiolabeling, and testing of Tc-99m-labeled rotenone complexes as single photon emitting probes for improved delineation of myocardial perfusion. The Tc-99m-rotenone derivatives have unique properties. The instant invention also relates to technetium-99m-labeled rotenone derivatives which exhibit high uptake and retention in the myocardium in proportion to flow. Another aspect of the present invention relates to kits compring a Tc-99m-labeled rotenone derivative.