CAS: 1189-71-5; Sulfurisocyanatidic Chloride

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CAS号7446-11-9 三氧化硫 | CAS号506-77-4 氯化氰 | CAS号63549-29-1 Chlordisulfuryl... | CAS号108161-13-3 1,3,5-三甲基-1H-吡唑-4-甲腈 | CAS号108555-00-6 (4-nitrophenyl)... | CAS号111291-56-6 5-Azaspiro[2.4]... | CAS号111291-55-5 7-azadispiro[2.... | CAS号73496-24-9 7-methylene-4-o... | CAS号107-69-7 2,2,2-Trichloro... | CAS号110047-13-7 (2,5-dimethylph... | CAS号1093066-63-7 3-脲啶呋喃-2-羧酸甲酯 | CAS号110230-97-2 5-(5-thiophen-2... | CAS号108536-12-5 (3,4,4-trimethy...

氯化氰置于三氧化硫吡啶体系中,用76.6%的收率获得氯磺酰异氰酸酯
参考文献:一种连续法合成氯磺酰异氰酸酯的方法
标题:一种连续法合成氯磺酰异氰酸酯的方法
摘要:本发明提供一种连续法合成氯磺酰异氰酸酯的方法,包括以下步骤:A)将氯氰与三氧化硫在一段静态混合器中进行反应,反应后的物料进入连续降膜分离装置,分离得到气相的氯磺酰异氰酸酯和液相的六元环副产物;B)将所述六元环副产物通入连续降膜分解器中,进行加热分解,得到氯磺酰异氰酸酯,氯氰和三氧化硫,所述氯氰和三氧化硫作为原料返回所述一段静态混合器中套用.本发明通过分段进行反应和分离,达到了减少固体废物的生成并提高原料利用率的效果.实验结果表明,本发明中的方法直接得到的氯磺酰异氰酸酯纯度为97.0%左右,氯磺酰异氰酸酯的单程收率大于75.0%,循环收率大于95.0%,分解蒸发器中几乎没有固体残渣.

专利信息

专利号:US-9193691-B2
优先权日:2012-04-27
标题:Methods for the synthesis of activated ethylfumarates and their use as intermediates
发明人：KRAFT KELLY SULLIVAN; FREEMAN JOHN J; SERWINSKI PAUL; PAVIA VINNIE; PHANSTIEL OTTO; KAUR NAVNEET
权利人:MANNKIND CORP; MANNKIND CORP
摘要:Disclosed embodiments relate to improved methods for the synthesis of activated fumarate intermediates and their use in chemical synthesis. Disclosed embodiments describe the synthesis of activated fumarate esters including those derived from activating groups including: 4-nitrophenyl, diphenylphosphoryl azide, pivaloyl chloride, chlorosulfonyl isocyanate, p-nitrophenol, MEF, trifluoroacetyl and chlorine, for example, ethyl fumaroyl chloride and the subsequent use of the activated ester in situ. Further embodiments describe the improved synthesis of substituted aminoalkyl-diketopiperazines from unisolated and unpurified intermediates allowing for improved yields and reactor throughput.

专利号:WO-2024144721-A1
优先权日:2022-12-31
标 题 :A new method for the synthesis of primary carbamates
发明人：ATMACA UFUK
权利人:ATATUERK UENIVERSITESI FIKRI MUELKIYET HAKLARI KOORDINATOERLUEGUE DOENER SERMAYE ISLETMESI
摘要:The present invention relates to the synthesis by a new method of a primary carbamate functional group, which forms the basic core of the structure of many pharmaceutical agents and natural products and is used as a starting compound for the synthesis of many organic molecules, and relates to a method to be used in the field of primary carbamate groups, pharmaceutical industry and organic chemistry.

专利号:US-7015321-B2
优先权日:2002-10-12
标 题 :Synthesis of non-symmetrical sulfamides using burgess-type reagents
发明人：NICOLAOU KYRIACOS C; LONGBOTTOM DEBORAH; SNYDER SCOTT A; HUANG XIANHAI
权利人:SCRIPPS RESEARCH INST
摘要:A practical and high-yielding method for the efficient, one-step synthesis of diverse classes of N,N′-differentiated sulfamides employs a wide range of amino alcohols and simple amines using Burgess-type reagents. This methodology extends the application and availability of sulfamides within the fields of chemical biology, medicinal chemistry, asymmetric synthesis, and supramolecular chemistry.

专利号:US-2023286915-A1
优先权日:2020-10-07
标 题 :Synthesis of pyrrole acid derivatives
发明人：WILKINSON ANDREW; COOPER LAN; ORR DAVID; FINLAYSON JONATHAN; BUNT ADAM; KIRKHAM JAMES; LYTH DAVID; BLADES KEVIN
权利人:INFEX THERAPEUTICS LTD
摘要:This invention relates to the synthesis of compounds that can be used to treat bacterial infections in combination with other antibacterial agents, and more specifically in combination with a class of antibacterial agents known as carbapenems. The compounds resulting from the novel methods of the present invention are enzyme inhibitors and more particularly are metallo-β-lactamase inhibitors.

专利号:US-5639877-A
优先权日:1993-07-30
标题:Intermediates in the synthesis of cephalosporins
发明人：LUDESCHER JOHANNES; MACHER INGOLF
权利人:BIOCHEMIE GMBH
摘要:Novel amidine salts of 7-Amino-3-hydroxymethyl-3-cephem-4-carboxylic acid (=HACA), particular guanidine and diaza-bicyclo-alkylene salts, are useful as intermediates in the synthesis of cephalosporins.

专利号:US-2020354404-A1
优先权日:2019-05-09
标 题 :Peptidomimetic agents, synthesis and uses thereof
发明人：AL-ABED YOUSEF
权利人:FEINSTEIN INSTITUTES FOR MEDICAL RESEARCH
摘要:Compounds for use in synthesis of peptidomimetic agents; synthesis of peptidomimetic agents; peptidomimetic diagnostic and therapeutic agents; and uses of the compounds and peptidomimetic agents in drug discovery, diagnosis, prevention and treatment of diseases are described.