CAS: 112809-25-3; 4-((1H-1,2,4-Triazol-1-yl)Methyl)Benzonitrile

相似化合物

160388-54-5 6085-94-5 119192-10-8

上下游产品

CAS号41253-21-8 1,2,4-三氮唑钠 | CAS号17201-43-3 α-溴对甲基苯甲腈 | CAS号288-88-0 1,2,4-三氮唑 | CAS号112809-26-4 4-(1H-1,2,4-tri... | CAS号112809-52-6 4,4'-(4H-1,2,4-... | CAS号112809-51-5 来曲唑

4-[1-(1,2,4-Triazolyl)Methyl]Benzonitrile Hydrochoride置于sodium Hydroxide体系中,用 二氯甲烷,水 用作溶剂,化学反应 0.33H,反应生成4-(1H-1,2,4-三唑-1-基甲基)苯甲腈
参考文献: A Method For The Separation Of The Letrozole Precursor 4-'1-(1,2,4-Triazolyl) Methyl!Benzonitrile From Its 1,3,4-Triazolyl Isomer[fr] Procede De Separation Du Precurseur De 4-1-(1,2,4-Triazolyl) Methyl!Benzonitrile Et De Son Isomere 1,3,4-Triazolyle
标题: A Method For The Separation Of The Letrozole Precursor 4-'1-(1,2,4-Triazolyl) Methyl!Benzonitrile From Its 1,3,4-Triazolyl Isomer[fr] Procede De Separation Du Precurseur De 4-1-(1,2,4-Triazolyl) Methyl!Benzonitrile Et De Son Isomere 1,3,4-Triazolyle
摘要:一种用于分离来曲唑前体4-[1-(1,2,4-三唑基)甲基]苯腈(公式i)的反应中产生的同分异构体副产物4-[1-(1,3,4-三唑基)甲基]苯腈(公式ii)的化学方法,包括以下步骤:(A) 通过常规方法制备公式(I)和(II)的化合物的同分异构体混合物.(B) 将得到的粗同分异构体混合物溶解在二氯甲烷(或)氯仿中.(C) 向所得溶液中加入10-14%异丙醇盐酸盐(ipachi).(D) 加入异丙醚以沉淀不希望的异构体,以盐酸形式存在.(E) 过滤掉不需要的异构体盐酸.(F) 将滤液完全蒸馏掉.(G) 向残留物中加入稀释的氢氧化钠溶液和二氯甲烷,以释放所需的公式(I)的异构体碱基.(H) 蒸发分离的二氯甲烷层,并加入己烷或石油醚.(I) 对得到的公式(I)的产品进行离心,并使用己烷或石油醚进行洗涤.

专利信息

专利号:WO-2010146391-A1
优先权日:2009-06-15
标题:Regioselective synthesis of letrozole
发明人：GORE VINAYAK GOVIND; SHUKLA VINAY KUMAR; BHANDARI SHERYAS; HASBE SURESH; MEKDE SANDEEP
权利人:GENERICS UK LTD; MYLAN INDIA PRIVATE LTD; GORE VINAYAK GOVIND; SHUKLA VINAY KUMAR; BHANDARI SHERYAS; HASBE SURESH; MEKDE SANDEEP
摘要:The present invention relates to an improved process for the preparation of letrozole (I) and its pharmaceutically acceptable salts, to compositions comprising letrozole or a pharmaceutically acceptable salt thereof, and to uses of such compositions. In particular it relates to a process and to novel intermediates for preparing letrozole and its salts substantially free from regioisomeric impurities.

专利号:US-7705159-B2
优先权日:2005-07-06
标题:Process for the preparation of letrozole
发明人：MACDONALD PETER LINDSAY; BIGATTI ETTORE; ROSSETTO PIERLUIGI; HAREL ZVI
权利人:SICOR INC
摘要:The invention provides a high-yield process for the preparation of letrozole having a high purity, without the need for removal of the 4-[1-(1,3,4-triazolyl)methyl]benzonitrile impurity at the intermediate stage. The invention also provides a process for the synthesis of letrozole in which formation of the impurity 4-[1-(1,3,4-triazolyl)methyl]benzonitrile during the first stage is minimized. In the process, a 4-(halomethyl)benzonitrile is reacted with a salt of 1H-1,2,4-triazole, reducing the formation of the impurity. Preferably, the preparation is conducted as a one-pot process.

专利号:US-8003804-B2
优先权日:2006-03-17
标题:Synthesis of 4-[1-(4-cyano phenyl)-(1,2,4-triazol-1-yl)methyl] benzonitrile and 4-[1-(1H-1,2,4-triazol-1-yl)methylene benzonitrile intermediate
发明人：PATHI SRINIVAS LAXMINARAYAN; KANKAN RAJENDRA NARAYANRAO; RAO DHARMARAJ RAMACHANDRA; VASANT CHIKHALIKAR SANDIP
权利人:CIPLA LTD
摘要:The present invention relates to a process for the preparation of 4-[1-(4-cyano phenyl)-1-(1,2,4-triazol-1-yl)methyl]benzonitrile (letrozole), substantially free from its isomeric impurity. The preparation involves reaction of 4-[1-(1H-1,2,4-triazol-1-yl)methylene benzonitrile with 4-fluorobenzonitrile in the presence of an organic solvent and a silicon amine. The present invention also relates to a process for the preparation of 4-[1-(1H-1,2,4-triazol-1-yl)methylene benzonitrile which involves: (a) the reaction of a 4-halomethyl benzonitrile with 1,2,4-triazole in the presence of cesium carbonate and an organic solvent to obtain a reaction mass comprising 4-[1-(1,2,4-triazole-1-yl)methyl]benzonitrile of formula II; and (b) precipitation of 4-[1-(1,2,4-triazole-1-yl)methyl]benzonitrile (II) from the reaction mass using a suitable organic solvent.

专利号:WO-2007107733-A1
优先权日:2006-03-17
标 题 :Synthesis of 4-[1-(4-cyano phenyl)-(1,2,4-tr1azol-1-yl)methyl] benzonitrile and 4-[1-(1h-1,2,4-triazol-1-yl)methylene benzonitrile intermediate

专利号:KR-20080112306-A
优先权日:2006-03-17
标 题 :Synthesis of 4-[1-(4-cyano phenyl)-1-(1,2,4-triazol-1-yl)methyl] benzonitrile and 4-[1-(1h-1,2,4-triazol-1-yl)methylene benzonitrile intermediate

专利号:US-2009270633-A1
优先权日:2006-03-17
标题 :Synthesis of 4-[1-(4-cyano phenyl)-(1,2,4-triazol-1-yl)methyl] benzonitrile and 4-[1-(1H-1,2,4-triazol-1-yl)methylene benzonitrile intermediate