CAS: 107-41-5; 2-Methylpentane-2,4-Diol

相似化合物

99210-90-9 99113-75-4 141-73-1

上下游产品

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二丙酮醇置于lithium Aluminium Tetrahydride体系中,用 四氢呋喃 用作溶剂,化学反应 3.0H,以53%的收率获得2-甲基-2,4-戊二醇
参考文献:在室温下使用n-甲苯磺酰基-4-氯苯磺酰亚氨基氟化物(sulfoxfluor)对醇进行快速脱氧氟化
标题:在室温下使用n-甲苯磺酰基-4-氯苯磺酰亚氨基氟化物(sulfoxfluor)对醇进行快速脱氧氟化
摘要:醇类的脱氧氟化是获取烷基氟化物的最基本的方法,因此,迫切需要开发出耐贮存,易处理,氟经济且高选择性的脱氧氟化试剂.这项工作描述了结晶化合物n的发展甲苯磺酰基-4-氯苯磺酰亚胺基氟(sulfoxfluor),作为一种新型的脱氧氟化剂,具有上述所有优点,在脱氧氟化领域是罕见的.由于具有磺酰亚胺基的多维调节能力,Sulfoxfluor的氟化速率优于2-吡啶磺酰氟(pyfluor),并且在氟经济方面也优于全氟丁烷磺酰氟(pbsf).它与醇的反应不仅可以耐受各种功能,包括受空间位阻更大的醇羟基,而且还具有很高的氟化/消除选择性.由于sulfoxfluor可以轻松地由廉价的材料制成,并且无需特殊技术即可安全地进行处理,
Doi:10.1002/chem.201901176

专利信息

专利号:US-8084007-B2
优先权日:2004-01-30
标题 :Methods of synthesis of isotropically enriched borohydride and methods of synthesis of isotropically enriched boranes
发明人：SPIELVOGEL BERNARD; COOK KEVIN S
权利人:SPIELVOGEL BERNARD; COOK KEVIN S; SEMEQUIP INC
摘要:The invention provides new methods for the synthesis of isotopically enriched metal borohydrides, metal tetrahydroundecaborate salts, and decaborane from isotopically enriched 10 B-boric acid or 11 B-boric acid. The invention is particularly useful for synthesis of isotopically enriched sodium or lithium borohydride, MB 11 H 14 (where M is Li, Na, K, or alkylammonium), and decaborane.

专利号:US-8258299-B2
优先权日:2009-03-27
标题:Process for preparation of temsirolimus
发明人：LEE KWANG-CHUNG; LEE TING-HUEI; TUNG YEN-SHIH; KAO CHIA-CHEN; LEE TZU-AI
权利人:LEE KWANG-CHUNG; LEE TING-HUEI; TUNG YEN-SHIH; KAO CHIA-CHEN; LEE TZU-AI; CHUNGWA CHEMICAL SYNTHESIS & BIOTECH CO LTD
摘要:The present invention provides two synthetic routes for the preparation of Temsirolimus (compound 1b and analog of Temsirolimus 1a). The first route includes the synthesis of CCI-779 by directly reacting rapamycin (4b) or Prolyl-rapamycin (4a) with substituent-2,2-bis(methoxy) propionic acid anhydride(11) in the presence of an organic base, followed by deprotection to give CCI-779 or Proline CCI-779. The second route includes a process involving a reaction of rapamycin-OH-31-sily ether (4d) or Prolyl-rapamycin-OH-31-sily ether (4c) with substituent-2,2-bis(methoxy) propionic acid anhydride(11) in the presence of an organic base and followed by subsequent hydrolysis step to obtain the desired CCI-779 or Proline CCI-779. n Compound 11, as described in this invention, is stable at room temperature, cost effective and ease of processing.

专利号:US-7153957-B2
优先权日:2003-08-07
标 题:Regioselective synthesis of CCI-779
发明人：CHEW WARREN; SHAW CHIA-CHENG
权利人:WYETH CORP
摘要:A method for regioselective synthesis of CCl-779 based on boronate chemistry is provided. Also provided are novel intermediates useful in this method.

专利号:WO-0125179-A1
优先权日:1999-10-01
标 题:Preparation of tetracyclic intermediates
发明人：CHEN QING PING; WOODS ROSS ALEXANDER; ELLIOTT ROBYN LOUISE
权利人:INST OF DRUG TECHNOLOGY AUSTRA; CHEN QING PING; WOODS ROSS ALEXANDER; ELLIOTT ROBYN LOUISE
摘要:The invention provides a process for preparing deoxytetracyclic compounds of formula (I) useful in the synthesis of anthracyclines by the rearrangement of thiono ester derivatives followed by reduction, as well as intermediates useful therefor. In said formula, R is H or optionally protected OH.

专利号:US-8354524-B2
优先权日:2001-03-22
标 题:Synthesis of selenium-derivatized nucleosides, nucleotides, phosphoramidites, triphosphates and nucleic acids
发明人：HUANG ZHEN
权利人:UNIV GEORGIA STATE RES FOUND; HUANG ZHEN
摘要:The present invention provides selenium derivatives of nucleosides, nucleoside phosphoramidites, nucleotides, nucleotide triphosphates, oligonucleotides, polynucleotides, and larger nucleic acids and methods for their synthesis. Selenium derivatives of both ribonucleic acids and deoxyribonucleic acids, as well as methods for their synthesis, crystallization and uses in structural determinations, particularly by X-ray crystallographic techniques are disclosed. The selenium derivatives of the present invention are also useful as food supplements.

专利号:US-2005003188-A1
优先权日:2003-03-21
标题 :Thermolytic synthesis of inorganic oxides imprinted with functional moieties
发明人：BASS JOHN D; KATZ ALEXANDER
权利人:UNIV CALIFORNIA
摘要:Inorganic oxides, particularly silica or germania or inorganic oxides containing silica and/or germania, are imprinted with one or a plurality of functional moieties such as amine and/or thiol groups by a process featuring incorporating such groups into the oxide by use of a thermally labile material containing a protecting group for the amine or thiol, followed by removal of the thermally labile moiety by thermolysis. The resulting products are inorganic oxide substrates or bulk inorganic oxides imprinted with the functional moieties. A plurality of such moieties may be imprinted on a substrate in an order fashion using a polymeric imprinting compound, and may then be used as a templated array of functional moieties to which ordered metallic nanostructures may be constructed.