CAS: 10465-81-3; Diazene-1,2-Diylbis(Piperidin-1-Ylmethanone)

上下游产品

CAS号110-89-4 六氢吡啶 | CAS号1972-28-7 偶氮二甲酸二乙酯 | CAS号103-82-2 苯乙酸

哌啶,偶氮二甲酸二乙酯置于petroleum Ether体系中,化学反应生成偶氮二甲酰二哌啶
参考文献:Diels; Fritzsche,Chemische Berichte,1911,Vol. 44,P. 3020
标题:Diels; Fritzsche,Chemische Berichte,1911,Vol. 44,P. 3020

专利信息

专利号:US-6399776-B2
优先权日:1994-08-05
标题:Processes and intermediates in the synthesis of 5-(3-exo-bicyclo[2.2.1]hept-2-yloxy-4-methoxyphenyl)-3,4,5,6-tetrahydropyrimidine-2(1H)-one
发明人：LACOUR THOMAS G; MURTIASHAW III CHARLES WILLIAM
权利人:PFIZER
摘要:This invention relates to novel processes for preparing the pharmaceutically active compound 5-(3-[(2S)-exo-bicyclo[2.2.1]hept-2-yloxy]-4-methoxyphenyl)-3,4,5,6-tetrahydropyrimidin-2(1H)-one and its corresponding 2R enantiomer and for preparing certain intermediates used in the synthesis of these compounds. It also relates to novel intermediates used in the synthesis of such pharmaceutically active compounds and to other novel compounds that are related to such intermediates.

专利号:US-9969685-B2
优先权日:2016-09-28
标 题 :Enantioselective synthesis of pyrroloindole compounds
发明人：SCHMIDT MICHAEL ANTHONY
权利人:BRISTOL MYERS SQUIBB CO
摘要:Compounds according to formula (I) or (II), wherein R 1 , R 2 , and R 3 are as defined in the specification, are versatile intermediates for the synthesis of DNA minor groove binder-alkylators having a cyclopropapyrroloindole (CPI) or seco-CPI alkylating subunit.

专利号:US-10556913-B2
优先权日:2015-07-21
标 题:Asymmetric process for the preparation of thieno-indoles derivatives
发明人：BERIA ITALO; CARUSO MICHELE; DONATI DANIELE; ORSINI PAOLO
权利人:NERVIANO MEDICAL SCIENCES SRL
摘要:The present invention relates to a new process for the preparation of thieno-indole derivatives of formula (Ia) or (Ib), exploiting an asymmetric synthesis for the preparation of key (8S) or (8R) 8-(halomethyl)-1-alkyl-7,8-dihydro-6H-thieno[3,2-e]indol-4-ol intermediates, and to useful intermediate compounds of such process. n Thieno-indole derivatives are described and claimed in GB2344818, WO2013/149948 and WO2013/149946, which also disclose processes for their preparation. n Thieno-indole enantiopure derivatives can now be advantageously prepared through a new asymmetric synthesis of the key 8-(halomethyl)-7,8-dihydro-6H-thieno[3,2-e]indol intermediates, which, avoiding the chiral resolution step, provides benefits in terms of reducing time and costs of the whole process for their preparation. The synthesis starts from the N-alkylation of 5-amino-4-halo-3-alkyl-1-benzothiophene-7-ol derivatives with enantiopure glycidyl 3-nosylate, followed by intramolecular 6-endo-tet cyclization using alkyl Grignard reagents; Mitsunobu activation of the secondary alcohol promotes internal spirocyclization, affording the 4,4a,5,6-tetrahydro-8H-cyclopropa[c]thieno[3,2-e]indol-8-one derivatives; finally, stereo-electronically controlled regioselective cyclopropane opening yields the key enantiopure 8-(halomethyl)-1-alkyl-7,8-dihydro-6H-thieno[3,2-e]indol-4-ol intermediates; which can be further derivatized following teachings disclosed in WO2013/149948 or WO2013/149946, to prepare the final thieno-indole derivatives of formula (Ia) or (Ib). n Such compounds are disclosed to be alkylating compounds with cytotoxic activity, therefore useful as such in the treatment of a variety of cancers and in cell proliferative disorders, or, conjugated with different types of nucleophiles, in the preparation of Antibody Drug Conjugated derivatives.

专利号:US-9732112-B2
优先权日:2010-05-28
标 题:Synthesis of 2′,3′-dideoxynucleosides for automated DNA synthesis and pyrophosphorolysis activated polymerization
发明人：MA ZHAOCHUN; MULLAH KHAIRUZZAMAN BASHAR; EASON ROBERT G
权利人:LIFE TECHNOLOGIES CORP
摘要:Methods for preparation of 2′,3′-dideoxynucleotides support structures, such as 2′,3′-dideoxyguanosine, 2′,3′-dideoxyadenosine, and 3′-deoxythymidine support structures are disclosed. Various methods of using such structures are also provided, such as their use for automated DNA synthesis and pyrophosphorolysis activated polymerization.

专利号:EP-1105359-B1
优先权日:1998-08-21
标 题:Solid phase synthesis of compounds by carbon-carbon bond forming mitsunobu reactions
发明人：CHATURVEDI SURENDRAKUMAR
权利人:PE CORP NY
摘要:Processes are provided for the Mitsunobu alkylation reaction of carbon-carbon bond formation between a solid support reagent and a reagent in solution. The resulting novel products can be prepared as a combinatorial library by high-throughput, parallel synthesis under robotic automation. Cleaved or support-bound products are useful precursors to biologically active compounds.

专利号:US-9359327-B2
优先权日:2008-06-30
标题:Process for the preparation of substituted pyrimidine derivatives
发明人：CESCO-CANCIAN SERGIO; CHEN HONGFENG; GRIMM JEFFREY S; MANI NEELAKANDHA S; MAPES CHRISTOPHER M; PALMER DAVID C; PIPPEL DANIEL J; SORGI KIRK L; XIAO TONG
权利人:JANSSEN PHARMACEUTICA NV
摘要:The present invention is directed to processes for the preparation of substituted pyrimidine derivatives, useful as intermediates in the synthesis of histamine H 4 receptor modulators, and to intermediates in H4 modulator synthesis.