CAS: 104530-16-7; (1R,4S)-4,7,7-Trimethyl-3-Oxo-2-Oxabicyclo[2.2.1]Heptane-1-Carbonyl Chloride

上下游产品

(-)-camphanic acid 1,2,2-trimethyl-cyclopentane-1,3-dicarbonyl chloride 1-Bromo-5,8,8-trimethyl-3-oxa-bicyclo[3.2.1]°Ctane-2,4-dione (+)-camphoric acid 1D-2,3,6-Tri-O-benzyl-4,5-O-isopropylidene-myo-inositol (+)-ω-camphanate (1R,4S)-4,7,7-Trimethyl-3-oxo-2-oxa-bicyclo[2.2.1]heptane-1-carboxylic acid (3aS,4S,5S,6S,7R,7aS)-4,6,7-tris-benzyloxy-2,2-dimethyl-hexahydro-benzo[1,3]dioxol-5-yl ester (1R,4S)-4,7,7-Trimethyl-3-oxo-2-oxa-bicyclo[2.2.1]heptane-1-carboxylic acid (1R,2S,3S,4R,5R,6S)-2,3,4,6-tetrakis-benzyloxy-5-hydroxy-cyclohexyl ester (1R,4S)-4,7,7-Trimethyl-3-oxo-2-oxa-bicyclo[2.2.1]heptane-1-carboxylic acid (1S,2R,3R,4S,5S,6R)-2,3,4,6-tetrakis-benzyloxy-5-hydroxy-cyclohexyl ester

(1R)-(+)-莰烷酸置于氯化亚砜体系中,化学反应 3.0H,反应生成(1S)-3-氧代-4,7,7-三甲基-2-氧杂双环[2.2.1]庚烷-1-甲酰氯
参考文献:2-(1,2,3,4-Tetrahydro-1-Isoquinolyl)-乙醇衍生物与 μ 和 κ 受体结合的不对称合成和对映特异性
标题:2-(1,2,3,4-Tetrahydro-1-Isoquinolyl)-乙醇衍生物与 μ 和 κ 受体结合的不对称合成和对映特异性
摘要:许多 2-(1,2,3,4-四氢-1-异喹啉基)-乙醇衍生物 7A-E 已经以非对映体和对映体纯形式合成,并评估了它们对 μ 和 κ 阿片受体的结合亲和力.酰胺酮 5A-C 和 Ent-5A-C 可通过将 3B 和 Ent-3B 用于不对称亲电酰胺烷基化反应而获得,用作起始化合物.5A-C和ent-5A-C还原得到酰胺醇l-6A-C,U-6A-C,Ent-L-6A-C和ent-U-6A-C.这些化合物的水解产生仲氨基醇 L-7A-C,U-7A-C,Ent-L-7A-C 和 Ent-U-7A-C,并且在 L-7B-C,U-7B 的还原甲基化后-c,Ent-L-7B-c 和 Ent-U-7B-c 与 Ch2O 和 Nacnbh3 叔氨基醇 L-7D-E,U-7D-E,Ent-L-7D-E 和 Ent-U-得到7D-E.
Doi:10.1002/ardp.19963290104

专利信息

专利号:US-8273403-B2
优先权日:2002-05-10
标题 :Generation of surface coating diversity
发明人：BARDEN MICHAEL C; KAMBOURIS PETER A
权利人:BARDEN MICHAEL C; KAMBOURIS PETER A; BIO LAYER PTY LTD
摘要:This invention relates to a surface discovery system and high-throughput combinatorial synthesis methods for generating large numbers of diverse surface coatings on solid substrates. The system is built upon a synthon which comprises at least three elements: a chemical backbone coating on the solid substrate that comprises a copolymer (B) of at least one passive constituent (P) and at least one active constituent (A); a spacer unit (S) separating the backbone from a functional group; and a functional group (F). The methods comprise the following steps: 1) selecting a plurality of synthons so that each synthon has at least two points of diversity selected from P, A, S and F; 2) applying copolymer B onto a substrate; and 3) attaching a combination of S and F to constituent A of copolymer B. Steps 2) and 3) are performed such that different synthons are generated on localized regions of the substrate.