CAS: 103146-25-4; 4-(4-(Dimethylamino)-1-(4-Fluorophenyl)-1-Hydroxybutyl)-3-(Hydroxymethyl)Benzonitrile

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CAS号103146-26-5 4-[4-(二甲氨基)-1-(... | CAS号19070-16-7 magnesium,N,N-d... | CAS号82104-74-3 5-氰基苯酞 | CAS号460-00-4 对氟溴苯 | CAS号717133-25-0 4-[4-(二甲氨基)-1-(... | CAS号260371-16-2 4-(4-氟苯甲酰基)-3-羟... | CAS号352-13-6 4-氟苯基溴化镁 | CAS号5407-04-5 3-二甲氨基氯丙烷盐酸盐 | CAS号488787-59-3 (S)-4-[4-(二甲胺基)... | CAS号59729-32-7 氢溴酸西酞普兰 | CAS号59729-33-8 西酞普兰 | CAS号64372-56-1 1-[3-(二甲基氨基)丙基]... | CAS号128196-01-0 艾司西酞普兰 | CAS号219861-08-2 草酸右旋西酞普兰

N,N-二甲氨基氯丙烷盐酸盐置于potassium Hydroxide体系中,用 四氢呋喃,水 用作溶剂,化学反应 4.75H,反应生成4-(4-二甲胺基-1-对氟苯基-1-羟基丁基)-3-(羟甲基)苯腈
参考文献:Preparation Of Escitalopram,Its Salts And Intermediates
标题:Preparation Of Escitalopram,Its Salts And Intermediates
摘要:本专利申请涉及一种改进的埃司他洛普兰,其盐和中间体的制备方法.它还涉及到西酞普兰二醇中间体的一种新的结晶形式s,以及用于制备西酞普兰,埃司他洛普兰及其盐的方法.

专利信息

专利号:US-2008119662-A1
优先权日:2004-02-16
标 题:One Spot Synthesis of Citalopram from 5-Cyanophthalide
发明人：NARAHARI BABU AMBATI; SRINIVAS GOUD VUDDAMARI; GAONKAR SANTOSH LAXMAN; MANJUNATHA SULUR G; KULKARNI ASHOK KRISHNA; KULKARNI MADHARI A
权利人:JUBILANT ORGANOSYS LIMTED
摘要:A process for one pot synthesis of citalopram is disclosed. The process comprises subjecting 5-cyano phthalide to Grignard reduction followed cyclization and followed by C-alkylation reaction to obtain citalopram without isolation and purification of any intermediates. In another embodiment, 5-cyano phthalide is subjected to sequential Grignard reactions followed by cyclization to obtain citalopram without isolation and purification of any intermediate stages.

专利号:US-2008199922-A1
优先权日:2005-06-22
标题 :Chemoenzymatic Process for the Synthesis of Escitalopram
发明人：COTTICELLI GIOVANNI; SALVETTI RAUL; BERTONI CHIARA
权利人:ADORKEM TECHNOLOGY SPA
摘要:A process is described for the preparation of escitalopram and the pharmaceutically acceptable salts thereof starting from 5-cyanophthalide by a process which provides an enantioselective enzymatic deacylation reaction of a complex of the formula (IV) where R represents a C 1 -C 4 alkyl residue or an aryl residue under the action of an esterase from Aspergillus niger.

专利号:US-7166729-B2
优先权日:2001-08-02
标 题:Process for the preparation of 5-substituted isobenzofurans
发明人：DALL ASTA LEONE; COTTICELLI GIOVANNI
权利人:INFOSINT SA
摘要:There is described a process for the preparation of citalopram and of its pharmaceutically acceptable salts, which comprises treating a 1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-5 isobenzofurancarbaldoxime, O-substituted preferably with a diphenylmethyl or triphenylmethyl group, with formic-acetic anhydride. Furthermore, the total synthesis of citalopram, as free base or in form of its pharmaceutically acceptable salt, starting from 5-formylphthalide is described.

专利号:CN-106892837-A
优先权日:2017-03-23
标题 :Synthesis of 4-[4-(dimethylamino)-1-(4-fluorophenyl)-1-hydroxybutyl]-3-hydroxymethylbenzonitrile

专利号:CH-692298-A5
优先权日:1999-10-25
标 题 :Process for the preparation of intermediates for citalopram synthesis and for the production of escitalopram.