CAS: 93594-39-9; 1-Cyclopropyl-6-Fluoro-7-(4-Formylpiperazin-1-yl)-4-Oxo-1,4-Dihydroquinoline-3-Carboxylic Acid

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105404-65-7 93594-20-8 103237-52-1

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formic acid ciprofloxacin hydr°Chloride ciprofloxacin N,N-dimethyl-formamide1-cyclopropyl-6-fluoro-7-(4-(3-(6-fluorobenzo[d]thiazol-2-yl)-4-oxothiazolidin-2-yl)piperazin-1-yl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid 25H21F2N5O3SC25H21F2N5O3S 26H21FN6O3SC26H21FN6O3S 28H23FN6O4S2C28H23FN6O4S2

📜1-Cyclopropyl-6-Fluoro-4-Oxo-7-(4-((2-(4-Fluorobenzoyl)Hydrazono)Methyl)Piperazin-1-yl)-1,4-Dihydroquinoline-3-Carboxylic Acid置于水,乙酸酐体系中,用 二甲基亚砜 作为反应溶剂,化学反应 50.83H,反应生成 (环丙沙星m4)
参考文献:New Fluorine-Containing Hydrazones Active Against Mdr-Tuberculosis
标题:New Fluorine-Containing Hydrazones Active Against Mdr-Tuberculosis
摘要:Several New Fluorine-Containing Hydrazones Were Synthesized And Screened For Their In Vitro Anti-Mycobacterial Activity. Nine Of These Derivatives Have Shown A Remarkable Activity Against Mdr-Tb Strain With Mic 0.5 Mu G/ml And High Value Of Selectivity Index (Si). Compound 3H With The Highest Si (1268.58) Was Used For Stability Evaluation With Putative Metabolites (Ciprofloxacin And Formylciprofloxacin) Detection. Compound 3H Was Stable At Ph 7.4 Of Aqueous Buffer And Rat Plasma,In Acidic Buffers (At Ph 3 And 5) Slow Decomposition Was Observed. Interestingly,No Formylciprofloxacin Was Detected In The Solution,And Only Slightly Increased Concentration Of Ciprofloxacin Was Observed Instead. Trifluoromethyl Hydrazones 3F And 3G Exhibited The Best Activity Also Against Two Strains Of Mycobacterium Kansasii (Mic 1-4 Mu Mol/l). All Evaluated Compounds Were Found To Be Non-Cytotoxic. (C) 2011 Elsevier Masson Sas. All Rights Reserved.
DOI:10.1016/j.Ejmech.2011.07.052