CAS: 870521-31-6; 5-Bromo-2-Isopropoxypyridine

该化合物是一种有机化合物,其特征是其环,这是一个六人组成的芳香热循环,含有一个氮原子;5点有溴原子,2点有1甲基乙氧组,其独特的化学特性是存在的.该化合物一般没有色素,可粉黄液体或固体,取决于其纯度和形态.它溶于有机溶剂,因此在各种化学反应中有用,特别是在合成药物和农用化学品方面.溴基子子成分可参与核肺细胞替代反应,而甲基乙氧基成分组则可影响该化合物的再活动性和溶性.此外,环中存在的氮原子可结合氢,影响化合物在生物系统中的相互作用.

英文名称5-Bromo-2-Isopropoxypyridine
中文名称5-溴-2-异丙氧基吡啶
IUPAC名称5-bromo-2-isopropoxypyridine
其它别名2-异丙氧基-5-溴吡啶; Pyridine, 5-Bromo-2-(1-Methylethoxy)-
CAS编号870521-31-6
MFCD编号:MFCD07368869
EINECS号:680-941-7
分子式:C8H10BrNO
分子量:216.08
产品CID: 1875048
产品分类有机原料→分子砌块→芳杂环类化合物→吡啶类化合物

相似结构搜索
InChIKey: FSZRSTNRZUIEMA-UHFFFAOYSA-N
InChI=1S/C8H10BrNO/c1-6(2)11-8-4-3-7(9)5-10-8/h3-6H,1-2H3…
计算化学: 氢键受体数2.0氢键供体数0可旋转键数2

相似化合物

850495-91-9 55849-30-4 1142194-24-8

MSDS等安全信息

GHS符号GHS07
危险类别特定目标器官毒性 - 单次接触类别3
皮肤腐蚀/刺激类别2
严重眼刺激类别2A
警示词Warning
危险描述H335 |可能引起呼吸道刺激.
H315 |造成皮肤刺激.
H319 |造成严重眼刺激.
防范说明P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
危险品标志Xn
安全声明26-39
危险类别码22-37/38-41

欧盟法规

C&L通报

上下游产品

合成工艺路线路线简述

766-11-0 = 870521-31-6
反应条件:1.1 Reagents: Sodium Solvents: Isopropanol; 3 H,Reflux; Reflux -> Rt1.2 0.5 H,80 °C
标题:3,5-Dialkoxypyridine Analogues Of Bedaquiline Are Potent Antituberculosis Agents With Minimal Inhibition Of The Herg Channel
作者:Sutherland,Hamish S.; Et Al
参考文献:Bioorganic & Medicinal Chemistry 日期:2019 卷标:27(7) 页码:1292-1307]

= 870521-31-6
反应条件:1.1 Reagents: Sodium Isopropoxide; 130 °C2.1 Reagents: Sodium Bromide,Sulfuric Acid Solvents: Water; 4 H,25 - 35 °C2.2 Reagents: Sodium Hydroxide Solvents: Water; Basified
标题:Synthesis Of (Alkoxy)Pyridine Bromide And Its Diphenylphosphine Derivatives
作者:Liu,Jie; Et Al
参考文献:Huaxue Shiji 日期:2007 卷标:29(4) 页码:193-196]

13466-38-1 = 870521-31-6 + 851087-08-6
反应条件:1.1 Reagents: Potassium Carbonate,Polyoxyethylene Sorbitan Monolaurate Solvents: Water; Rt -> 70 °C; 18 H,70 °C; 70 °C -> Rt1.2 Reagents: Methanol
标题:Mild And Regioselective N-Alkylation Of 2-Pyridones In Water
作者:Hao,Xin; Et Al
参考文献:Organic Letters 日期:2015 卷标:17(14) 页码:3382-3385]

13466-38-1 = 870521-31-6
反应条件:1.1 Reagents: Potassium Carbonate Solvents: Dimethylformamide; 1 D,Rt
标题:Mk-8353: Discovery Of An Orally Bioavailable Dual Mechanism Erk Inhibitor For Oncology
作者:Boga,Sobhana Babu; Et Al
参考文献:Acs Medicinal Chemistry Letters 日期:2018 卷标:9(7) 页码:761-767]

766-11-0 = 870521-31-6
反应条件:1.1 Reagents: Sodium Hydride; 5 Min,25 °C; 16 H,25 °C1.2 Solvents: Dimethylformamide; 10 Min; 4 H,130 °C; 130 °C -> Rt
标题:Synthesis And Structure-Activity Relationships Of N-{3-[2-(4-Alkoxyphenoxy)Thiazol-5-Yl]-1- Methylprop-2-Ynyl}Carboxy Derivatives As Selective Acetyl-Coa Carboxylase 2 Inhibitors
作者:Gu,Yu Gui; Et Al
参考文献:Journal Of Medicinal Chemistry 日期:2006 卷标:49(13) 页码:3770-3773]

53939-30-3 = 870521-31-6
反应条件:1.1 Reagents: Sodium Hydride Solvents: Isopropanol; Rt -> 60 °C; 30 Min,60 °C1.2 Solvents: Isopropanol; 24 H,Reflux
标题:Novel Bisaryl Substituted Thiazoles And Oxazoles As Highly Potent And Selective Peroxisome Proliferator-Activated Receptor δ Agonists
作者:Epple,Robert; Et Al
参考文献:Journal Of Medicinal Chemistry 日期:2010 卷标:53(1) 页码:77-105]

16096-13-2 = 870521-31-6
反应条件:1.1 Reagents: Sulfuric Acid,Sodium Bromate Solvents: Water; 4 H,25 - 35 °C1.2 Reagents: Sodium Hydroxide Solvents: Water; Neutralized
标题:Synthesis Of 2-Alkyloxy-5-Bromopyridine
作者:Wang,Yue; Et Al
参考文献:Tianjin Shifan Daxue Xuebao 日期:2006 卷标:26(1) 页码:14-16]

16096-13-2 = 870521-31-6
反应条件:1.1 Reagents: Sodium Bromide,Sulfuric Acid Solvents: Water; 4 H,25 - 35 °C1.2 Reagents: Sodium Hydroxide Solvents: Water; Basified
标题:Synthesis Of (Alkoxy)Pyridine Bromide And Its Diphenylphosphine Derivatives
作者:Liu,Jie; Et Al
参考文献:Huaxue Shiji 日期:2007 卷标:29(4) 页码:193-196]

= 870521-31-6
反应条件:1.1 Reagents: Sodium1.2 8 H,2 Mpa,130 °C2.1 Reagents: Sulfuric Acid,Sodium Bromate Solvents: Water; 4 H,25 - 35 °C2.2 Reagents: Sodium Hydroxide Solvents: Water; Neutralized
标题:Synthesis Of 2-Alkyloxy-5-Bromopyridine
作者:Wang,Yue; Et Al
参考文献:Tianjin Shifan Daxue Xuebao 日期:2006 卷标:26(1) 页码:14-16

2-氟-5-溴吡啶置于sodium Hydride体系中,用 N,N-二甲基甲酰胺作为反应溶剂,化学反应 20.25H,以92%的收率获得产物2-异丙氧基-5-溴吡啶
参考文献:Novel Acetyl-Coa Carboxylase (Acc) Inhibitors And Their Use In Diabetes,Obesity And Metabolic Syndrome
标题:Novel Acetyl-Coa Carboxylase (Acc) Inhibitors And Their Use In Diabetes,Obesity And Metabolic Syndrome
摘要:本发明涉及式(I)的化合物,该化合物抑制乙酰辅酶a羧化酶(acc),对预防或治疗人类的代谢综合征,2型糖尿病,肥胖,动脉粥样硬化和心血管疾病有用.

海关参考信息

2905122000-异丙醇
2933310010-吡啶
2909199090-其他醚及其衍生物
2939800000-其他生物碱
💡 提示：海关信息按照顺序优先匹配，如需确认的海关信息，请参考相关资料。
详情请参考：📖 海关编码查询和海关进出口税则

专利信息

专利号:US-8742118-B2
优先权日:2011-10-27
标题 :Methods for preparing intermediates of perampanel
发明人：FONTANA FRANCESCO; STABILE PAOLO
权利人:F I S â€”FABBRICA ITALIANA SINT S P A
摘要:Methods for the synthesis of 2-alkoxy-5-(pyridin-2-yl)pyridine of formula I n nor salts thereof are provided.