CAS: 81161-17-3; Esmolol Hydrochloride

上下游产品

CAS号81147-94-6 4-(环氧乙烷甲氧基)-苯丙酸甲酯 | CAS号75-31-0 异丙胺 | CAS号501-97-3 对羟基苯丙酸 | CAS号5597-50-2 对羟基苯丙酸甲酯 | CAS号81148-15-4 3-{4-[2-hydroxy...

对羟基苯丙酸甲酯置于盐酸,Potassium Carbonate,间氯过氧苯甲酸,Potassium Iodide体系中,用 甲醇,二氯甲烷,甲基叔丁基醚,水,丙酮 作为反应溶剂,化学反应 26.0H,反应生成 盐酸艾司洛尔
参考文献:一种盐酸艾司洛尔及其制剂的制备
标题:一种盐酸艾司洛尔及其制剂的制备
摘要:本发明设计了新型的艾司洛尔盐酸盐合成路线,并制备出具有纳米线结构的甲基3‑[4‑(烯丙氧基)苯基]丙酸酯中间体,该结构使中间体更加稳定,有利于提高目标产物产率.本发明选取对溴苯酚为原料,首先是在醋酸钯的催化下与丙烯酸甲酯通过heck反应合成对羟基肉桂酸甲酯,选用钯碳催化氢化对羟基肉桂酸甲酯得到中间体对羟基苯丙酸甲酯,同时,利用烯丙基溴与羟基的协同作用进行醚化得到中间体甲基3‑[4‑(烯丙氧基)苯基]丙酸酯,经过间氯过氧苯甲酸,异丙胺开环氧化物氧化,与氯化氢成盐得到终产品艾司洛尔盐酸盐.本发明克服传统合成路线缺点,在合成工艺上实施了进一步优化,具有原料易得,操作简捷,反应条件温和的优点.

专利信息

专利号:US-9757463-B2
优先权日:2012-06-15
标题 :Linear polyester and semi-linear glycidol polymer systems: formulation and synthesis of novel monomers and macromolecular structures
发明人：HARTH EVA M; BEEZER DAIN B; LI GUANGZHAO; SPEARS BENJAMIN R; STEVENS DAVID M
权利人:UNIV VANDERBILT
摘要:Disclosed herein are glycidol-based polymers, nanoparticles, and methods related thereto useful for drug delivery. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.

专利号:US-6030613-A
优先权日:1995-01-17
标题:Receptor specific transepithelial transport of therapeutics
发明人：BLUMBERG RICHARD S; SIMISTER NEIL E; LENCER WAYNE I
权利人:BRIGHAM & WOMENS HOSPITAL; UNIV BRANDEIS
摘要:The present invention relates in general to methods and products for initiating an immune response against an antigen, and in particular relates to transepithelial delivery of antigens to provoke tolerance and immunity. The present invention further relates to methods and products for the transepithelial delivery of therapeutics. In particular, the invention relates to methods and compositions for the delivery of therapeutics conjugated to a FcRn binding partner to intestinal epithelium, mucosal epithelium and epithelium of the lung. The present invention further relates to the synthesis, preparation and use of the FcRn binding partner conjugates as, or in, pharmaceutical compositions for oral systemic delivery of drugs and vaccines.

专利号:US-7547436-B2
优先权日:1995-01-17
标 题:Receptor specific transepithelial transport of therapeutics
发明人：BLUMBERG RICHARD S; LENCER WAYNE I; SIMISTER NEIL E
权利人:BRIGHAM & WOMENS HOSPITAL; UNIV BRANDEIS
摘要:The present invention relates in general to methods and products for initiating an immune response against an antigen, and in particular relates to transepithelial delivery of antigens to provoke tolerance and immunity. The present invention further relates to methods and products for the transepithelial delivery of therapeutics. In particular, the invention relates to methods and compositions for the delivery of therapeutics conjugated to a FcRn binding partner to intestinal epithelium, mucosal epithelium and epithelium of the lung. The present invention further relates to the synthesis, preparation and use of the FcRn binding partner conjugates as, or in, pharmaceutical compositions for oral systemic delivery of drugs and vaccines.

专利号:US-9745419-B2
优先权日:2014-01-24
标 题 :Aqueous polyglycidol synthesis with ultra-low branching
发明人：HARTH EVA M; SPEARS BENJAMIN R
权利人:UNIV VANDERBILT
摘要:Disclosed herein are glycidol-based polymers, nanoparticles, and methods related thereto useful for a variety of applications, including, but not limited to, drug delivery. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.

专利号:WO-2024097977-A1
优先权日:2022-11-04
标题:Silk nanoparticle synthesis: tuning size, dispersity, and surface chemistry for drug delivery
发明人：SHAIDANI SAWNAZ; FALCUCCI THOMAS; FOSTER OLIVIA; SAHOO JUGAL KISHORE; HASTURK ONUR; KAPLAN DAVID L; JACOBUS CHARLOTTE S
权利人:TUFTS COLLEGE
摘要:Methods disclosed herein relate to generating silk nanoparticles with a low polydispersity index (PDI). Methods include adding a silk solution dropwise into a volatile solvent that is miscible with water, thereby forming a precipitate-bearing solution and applying shear forces to the precipitate-bearing solution for a length of time sufficient to achieve evaporation of at least 95% of the volatile solvent, thereby producing a population of silk fibroin nanoparticles in water having a polydispersity index (PDI) of 0.35 or less, including but not limited to, a PDI of 0.330 or less, 0.325 or less, 0.315 or less, 0.310 or less, 0.30 or less, 0.275 or less, 0.250 or less, 0.225 or less, or 0.200 or less. Parameters related to silk fibroin molecular weight, silk fibroin concentration, shear force application, and temperature may all be modified to achieve silk nanoparticles of a particular size exhibiting particular PDIs.

专利号:US-2016206743-A1
优先权日:2012-06-15
标题 :Linear Polyester and Semi-Linear Glycidol Polymer Systems: Formulation and Synthesis of Novel Monomers and Macromolecular Structures