Alkaline Earth Salt Of/the/ Methylsulfuric Acid置于camphor-10-Sulfonic Acid体系中,化学反应生成 (S)-2-氨基-1,1-二苯基-1-丙醇 参考文献:Molecular Rearrangements. Xi. The Deamination Of 1,1-Diphenyl-2-Amino-1-Propanol1 标题:Molecular Rearrangements. Xi. The Deamination Of 1,1-Diphenyl-2-Amino-1-Propanol1 摘要: DOI:10.1021/ja01580A015
专利号:US-2013253061-A1 优先权日:2012-03-20 标 题:Method of droxidopa synthesis 发明人:PIMPLASKAR HARISH K; KADAM SHASHIKANT VITHAL; MALLESH VOORADI; KAWALE PRAMOD MANGALDAS 权利人:CHELSEA THERAPEUTICS INC 摘要:The present application relates to a novel method of preparing L-threo-dihydroxyphenylserine (droxidopa). Specifically, the application is directed to a method of preparing droxidopa via a deprotection step that is an alternative to deprotection steps that have been previously disclosed. The new deprotection strategy is advantageous in that it avoids the need to use hydrogenolysis or hydrazine.
专利号:US-10597353-B2 优先权日:2015-11-11 标题:Processes for the preparation of diastereomerically and enantiomerically enriched oxazolines 发明人:BARRECA GIUSEPPE; RASPARINI MARCELLO; CARCONE LUCA; MORANA FABIO 权利人:QUIM SINTETICA S A 摘要:The invention relates to an industrially viable and advantageous process for the preparation of (2S,3 R)-2-amino-3-(3,4-dihydroxyphenyl)-3-hydroxypropanoic acid, having the following formula (I) generally known as Droxidopa, or of intermediates useful in the synthesis thereof.
专利号:CN-113549084-A 优先权日:2020-04-24 标题:A kind of method for stereoselective synthesis of chiral lactone
专利号:WO-2013142093-A1 优先权日:2012-03-20 标题 :Method for the synthesis of droxidopa
专利号:CN-113549084-B 优先权日:2020-04-24 标题 :A kind of method of stereoselective synthesis chiral lactone
专利号:CN-107686488-B 优先权日:2016-08-05 标 题 :Synthesis method of biotin intermediate
参考文献:10.1055/s-0037-1611654 摘要:Matsuoka S, Nakamura K, Ohmori K, Suzuki K. General Synthetic Approach to Rotenoids via Stereospecific, Group-Selective 1,2-Rearrangement and Dual SNAr Cyclizations of Aryl Fluorides. Synthesis. 2019 Jan 23;51(05):1139–56. doi: 10.1055/s-0037-1611654.