CAS: 6914-79-0; 1-Cyanocyclopropanecarboxylic Acid

该化合物是一种有机化合物,其特征是其独特的环丙烷结构,即三环碳环;该化合物的特征是环丙烷环附着一个环丙烷组(-CN)和一个碳球酸组(-COOH),有助于其再活性和在有机合成中的潜在应用;该环丙酸组的存在具有显著的极性,使该化合物成为各种化学反应中有用的中间体,包括核生殖器添加物和循环添加物.此外,该碳箱酸功能允许氢结合,影响其在极溶剂中的溶性. 1-环丙烷丙基酸组在药用化学和农用化学领域很有意义,可以作为更复杂的分子的建筑块.该组相对较低的分子重量和特定的功能组使其在合成有机化学中成为一种灵敏化合物.应当参考安全数据,以便处理与所有化学物质一样,确保使用期间采取适当的防范措施.

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相似化合物

598-10-7 98730-77-9 6914-73-4

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ECHA物质C&L通报

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合成工艺路线路线简述

    1-氰基环丙烷羧酸甲酯置于乙醇,Potassium Hydroxide体系中,化学反应 3.0H,以20.2%的收率获得产物1-氰基-1-环丙烷羧酸
    参考文献:Btk抑制剂及其用途
    标题:Btk抑制剂及其用途
    摘要:本发明公开了btk抑制剂及其用途,具体地,本发明提供一类杂芳化合物或其立体异构体,几何异构体,互变异构体,消旋体,氮氧化物,水合物,溶剂化物,代谢产物,药学上可接受的盐或前药,以及包含本发明化合物的药物组合物;本发明还公开了本发明化合物或其药物组合物在制备药物中的用途,该药物用于治疗自体免疫疾病,炎性疾病或增殖性疾病.

    海关参考信息

    专利信息


    专利号:US-9574189-B2
    优先权日:2005-12-01
    标题:Enzymatic encoding methods for efficient synthesis of large libraries
    发明人:FRANCH THOMAS; LUNDORF MIKKEL DYBRO; JACOBSEN SØREN NYBOE; OLSEN EVA KAMPMANN; ANDERSEN ANNE LEE; HOLTMANN ANETTE; HANSEN ANDERS HOLM; SØRENSEN ANDERS MALLING; GOLDBECH ANNE; DE LEON DAEN; KALDOR DITTE KIEVSMOSE; SLØK FRANK ABILDGAARD; HUSEMOEN GITTE NYSTRUP; DOLBERG JOHANNES; Jensen Kim Birkebæ; PEDERSEN LENE; NØRREGAARD-MADSEN MADS; GODSKESEN MICHAEL ANDERS; GLAD SANNE SCHRØDER; NEVE SØREN; THISTED THOMAS; KRONBORG TINE TITILOLA AKINLEMINU; SAMS CHRISTIAN KLARNER; FELDING JAKOB; FRESKGÃ…RD PER-OLA; GOULIAEV ALEX HAAHR; PEDERSEN HENRIK
    权利人:FRANCH THOMAS; LUNDORF MIKKEL DYBRO; JACOBSEN SØREN NYBOE; OLSEN EVA KAMPMANN; ANDERSEN ANNE LEE; HOLTMANN ANETTE; HANSEN ANDERS HOLM; SØRENSEN ANDERS MALLING; GOLDBECH ANNE; DE LEON DAEN; KALDOR DITTE KIEVSMOSE; SLØK FRANK ABILDGAARD; HUSEMOEN GITTE NYSTRUP; DOLBERG JOHANNES; Jensen Kim Birkebæ; PEDERSEN LENE; NØRREGAARD-MADSEN MADS; GODSKESEN MICHAEL ANDERS; GLAD SANNE SCHRØDER; NEVE SØREN; THISTED THOMAS; KRONBORG TINE TITILOLA AKINLEMINU; SAMS CHRISTIAN KLARNER; FELDING JAKOB; FRESKGÃ…RD PER-OLA; GOULIAEV ALEX HAAHR; PEDERSEN HENRIK; NUEVOLUTION AS
    摘要:Disclosed is a method for obtaining a bifunctional complex comprising a molecule linked to a single stranded identifier oligonucleotide, wherein a nascent bifunctional complex comprising a chemical reaction site and a priming site for enzymatic addition of a tag is a) reacted at the chemical reaction site with one or more reactants, and b) reacted enzymatically at the priming site with one or more tag(s) identifying the reactant(s).

    专利号:US-9676783-B2
    优先权日:2008-10-22
    标 题:Method of treatment using substituted pyrazolo[1,5-A] pyrimidine compounds
    发明人:HAAS JULIA; ANDREWS STEVEN W; JIANG YUTONG; ZHANG GAN
    权利人:ARRAY BIOPHARMA INC
    摘要:Compounds useful in the synthesis of compounds for treating pain, cancer, inflammation, neurodegenerative disease or Typanosoma cruzi infection in a mammal.

    专利号:US-4418155-A
    优先权日:1980-03-24
    标 题 :Conversion of synthesis gas to hydrocarbons enriched in linear alpha-olefins
    发明人:CHANG CLARENCE D; LANG WILLIAM H
    权利人:MOBIL OIL CORP
    摘要:A method is disclosed for converting synthesis gas to hydrocarbons enriched in linear alpha-olefins which involves the use of a ZSM-5 type zeolite which is substantially catalytically inert and onto which is deposited a carbon oxide reducing component including Fischer-Tropsch type catalysts, such as iron, cobalt and ruthenium.

    专利号:US-4344868-A
    优先权日:1979-08-13
    标题:Catalyst for synthesis gas conversion to oxygenates
    发明人:CHANG CLARENCE D; LANG WILLIAM H
    权利人:MOBIL OIL CORP
    摘要:The conversion of synthesis gas comprising hydrogen and carbon oxides to form oxygenate-containing mixtures which are limited compositionally in being virtually free of C 11 + compounds, with a zeolite which is virtually free of acid sites and characterized by a silica to alumina mole ratio of at least about 12 and a constraint index within the range of 1 to 12, having intimately combined therewith a metal selected from the group consisting of rhodium, platinum, palladium and iridium.

    专利号:US-4444909-A
    优先权日:1980-04-07
    标 题 :Synthesis gas conversion to oxygenates
    发明人:CHANG CLARENCE D; LANG WILLIAM H
    权利人:MOBIL OIL CORP
    摘要:The conversion of synthesis gas comprising hydrogen and carbon oxides to form oxygenate-containing mixtures which are limited compositionally in being virtually free of C 11 + compounds, with a zeolite which is virtually free of acid sites and characterized by a silica to alumina mole ratio of at least about 12 and a constraint index within the range of 1 to 12, having intimately combined therewith a metal selected from the group consisting of rhodium, platinum, palladium and iridium.

    专利号:US-11702652-B2
    优先权日:2005-12-01
    标题:Enzymatic encoding methods for efficient synthesis of large libraries
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    主要参考文献

    [参考文献]: Andrew J Kennedy, Et Al. Development Of Amidine-Based Sphingosine Kinase 1 Nanomolar Inhibitors And Reduction Of Sphingosine 1-Phosphate In Human Leukemia Cells. J Med Chem. 2011 May 26;54(10):3524-48.

    合成参考文献


    参考文献:10.1111/j.1747-0285.2009.00924.x
    摘要:Liu XH, Chen PQ, Wang BL, Dong WL, Li YH, Xie XQ, Li ZM. High throughput receptor-based virtual screening under ZINC database, synthesis, and biological evaluation of ketol-acid reductoisomerase inhibitors. Chem Biol Drug Des. 2010 Feb;75(2):228–32. doi: 10.1111/j.1747-0285.2009.00924.x.
    摘要:Sartori, G.; Maggi, R., Science of Synthesis, (2007) 20, 600.
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