CAS: 6665-83-4; 6-Hydroxy-2-Phenyl-4H-Chromen-4-One

上下游产品

benzoic acid ethyl ester 2',5'-dimethoxyacetophenone 1-acetyl-1,3-bis(benzoyloxy)benzene sodium benzoate 6-acetoxyflavone 6-hydroxy-5-formylflavone 6-(4-chlorobutoxy)-2-phenyl-4H-1-benzopyran-4-one flavone6-(6-chlorohexyl)oxyflavone

📜2,5-二羟基苯乙酮置于硫酸,Lithium Hexamethyldisilazane体系中,用 四氢呋喃 作为反应溶剂,化学反应 8.0H,反应生成 6-羟基黄酮
参考文献:设计,合成和生物学评估新型4H-Chromen-4-One衍生物作为抗多药耐药结核的抗结核药.
标题:设计,合成和生物学评估新型4H-Chromen-4-One衍生物作为抗多药耐药结核的抗结核药.
摘要:测试了通过支架变形苯并呋喃化合物tam16获得的一系列4H-Chromen-4-One衍生物的抗结核活性.化合物8D对药物敏感和耐多药结核病具有活性.初步可药性评估表明,化合物8D显示出非常好的小鼠和人微粒体稳定性,低细胞毒性和可接受的口服生物利用度.体内研究表明,在治疗3周后,化合物8D在tb的急性小鼠模型中显示出适度的功效.因此,8D是一种有前途的抗结核药物.
DOI:10.1016/j.Ejmech.2020.112075

专利信息

专利号:US-6482950-B1
优先权日:1991-05-06
标 题 :Squarylium compounds, and processes and intermediates for the synthesis of these compounds
发明人：GARCIA PAULINA P; LEE JOHN W; MARSHALL JOHN L; MCGOWAN DONALD A; PUTTICK ANTHONY J; SPENCER THOMAS K; STROUD STEPHEN G; TELFER STEPHEN J; ZURAW MICHAEL J
权利人:POLAROID CORP
摘要:Squarylium compounds of the formula: n wherein Q 1 and Q 2 are each independently a pyrylium, thiopyrylium, selenopyrylium, benzpyrylium, benzthiopyrylium or benzselenopyrylium nucleus, and R 1 and R 2 are each independently an aliphatic or cycloaliphatic group, can be prepared by reacting a squaric acid derivative of the formula: n with a compound of the formula Q 2 CH 2 R 2 in the presence of a base. The derivatives of Formula II may be prepared by condensing a 2,3,4,4-tetrahalocyclobut-2-en-1-one with a compound of the formula Q 1 CH 2 R 1 in the presence of a base to produce a compound of the formula: n wherein Q 1 and R 1 are as defined above, and X represents chlorine or bromine, and hydrolyzing the compound of Formula III. Alternatively, the derivatives of Formula II may be prepared by reacting a diester, monoacid chloride monoester or diacid chloride of squaric acid with a compound of the formula Q 1 CH 2 R 1 in the presence of a base, followed by hydrolysis of the resultant monoacid chloride or monoester derivative of the compound of Formula II to the parent compound.

专利号:US-12194020-B2
优先权日:2017-12-22
标 题:Reversing baldness through cannabinoid receptor activation
发明人：POSTREL RICHARD
权利人:POSTREL RICHARD
摘要:This invention reverses male pattern baldness by shocking dormant hair follicles out of their androgen induced hibernation phase back to the active hair-growing anagenic phase. The invention integrates two functions: 1) It blocks synthesis of compounds holding the follicles in the telogenic/hibernating phase and 2) It stimulates synthesis of compounds animating the hair-growing/anagenic phase in the follicular activity cycle. One preferred embodiment comprises an enzyme inhibitor blocking the conversion of testosterone to dihydrotestosterone (DHT), a flavonoid simultaneously increasing synthesis of prostaglandins alternative to prostaglandin D2, and a selected cannabinoid compound stimulating restore the hair follicle to its normal growth cycle. This novel trimodal therapy restores the hair follicles to their normal cycling processes and maintains these restorative properties so long as this rebalance in maintained.

专利号:CN-111850596-A
优先权日:2020-07-13
标题:A kind of continuous production method of electrochemical synthesis of sebacate compounds

专利号:US-9125843-B2
优先权日:2013-10-03
标 题 :Methods and compositions for improving the appearance of skin
发明人：PERNODET NADINE A; COLLINS DONALD F
权利人:PERNODET NADINE A; COLLINS DONALD F; ELC MAN LLC
摘要:A method for stimulating collagen synthesis in aging skin cells in need of treatment by topically applying a composition comprising at least one extract from Laminaria genus, at least one extract from the Narcissus genus, and at least one peptide that stimulates sirtuin 6 activity in the form of a peptide or a yeast extract where the peptide is component of the extract; and a treatment composition comprising at least one extract from Laminaria genus, at least one extract from the Narcissus genus; and at least one peptide that stimulates sirtuin 6 activity.

专利号:CA-2640585-A1
优先权日:2003-02-05
标题 :Synthesis of 2-butyl-3-(2'-(1-trityl-1h-tetrazol-5-yl)biphenyl-4-yl)-1,3-diazaspirol{4,4}-non-ene-4-one

专利号:US-5919950-A
优先权日:1991-05-06
标 题 :Squarylium compounds, and processes and intermediates for the synthesis of these compounds