CAS: 6468-96-8; 7-Hydroxy-3-Phenyl-2H-Chromen-2-One

该化合物是属于Cumarin家族的化学化合物,其特点是其独特的结构,包括一个带有苯基的Coumarin骨架,附在3号方位上;该复合物展示了一系列生物活动,包括抗氧化剂,抗炎和潜在的抗癌特性,使其对医药化学和药理学感兴趣.3-苯乙烯贝利酮在乙醇和二甲基硫氧化物等有机溶剂中可溶解,但其溶液在水中的溶解性有限.该复合体可通过各种方法合成,通常涉及适当的苯丙酸和碳基前体的凝聚.其荧光特性也值得注意,因为它在生物化学学学学的实验中可以用作荧光探针.此外,对3--苯贝利芬酮在抑制某些酶(例如可能对治疗应用产生影响的氰素)方面的作用进行了研究.总体而言,其独特的化学特性和生物活动使该化合物成为研究和潜在药物开发的宝贵化合物.

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CAS号6296-55-5 (2-oxo-3-phenyl... | CAS号103-82-2 苯乙酸 | CAS号95-01-2 2,4-二羟基苯甲醛 | CAS号103-80-0 苯乙酰氯 | CAS号93-35-6 伞形花内酯； 7-羟基香豆素 | CAS号98-09-9 苯磺酰氯 | CAS号71-43-2 苯 | CAS号17838-69-6 3-氧代-2-苯基丙酸乙酯 | CAS号108-46-3 间苯二酚 | CAS号673-22-3 2-羟基-4-甲氧基苯甲醛 | CAS号2555-22-8 7-Methoxy-3-phe... | CAS号97458-38-3 (2-oxo-3-phenyl...

合成工艺路线路线简述

    📜Sodium Phenylacetate置于硫酸,乙酸酐体系中,化学反应生成 7-羟基-3-苯基-2H-苯并吡喃-2-酮
    参考文献:Bargellini,Gazzetta Chimica Italiana,1927,Vol. 57,P. 461
    标题:Bargellini,Gazzetta Chimica Italiana,1927,Vol. 57,P. 461

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    专利信息


    专利号:US-7041812-B2
    优先权日:2001-08-29
    标题 :Labeled nucleoside polyphosphates
    发明人：KUMAR SHIV; SOOD ANUP
    权利人:AMERSHAM BIOSCIENCES CORP
    摘要:The present invention describes new compositions of matter in the form of labeled nucleoside polyphosphates with four or more phosphates. In addition compositions of nucleoside polyphosphates with four or more phosphates that are substrates for nucleic acid polymerases with enhanced substrate properties and methods of using these nucleoside polyphosphates for nucleic acid detection, characterization and quantification are described. The compositions provided by this invention include nucleoside polyphosphate, dideoxynucleoside polyphosphate, or deoxynucleoside polyphosphate analogues which have colorimetric, chemiluminescent, or fluorescent moieties, mass tags or an electrochemical tags attached to the terminal-phosphate. When a nucleic acid polymerase uses this analogue as a substrate, an enzyme-activatable label would be present on the inorganic polyphosphate by-product of phosphoryl transfer. Removal of the polyphosphate product of phosphoryl transfer via phosphate or polyphosphate transferring enzyme leads to a detectable change in the label attached thereon. When the polymerase assay is performed in the presence of a phosphatase, there is provided a convenient method for real-time monitoring of DNA or RNA synthesis and detection of a target nucleic acid.

    专利号:US-7563574-B2
    优先权日:2006-03-31
    标题:Methods, systems and compositions for monitoring enzyme activity and applications thereof
    发明人：KORLACH JONAS; TURNER STEPHEN
    权利人:PACIFIC BIOSCIENCES CALIFORNIA
    摘要:Methods of monitoring enzyme mediated reactions, and particularly nucleic acid synthesis reactions such as pyrosequencing methods that employ enzymatic reporter systems. The methods and systems provide elevated signal levels as compared to conventional pyrosequencing processes, and/or mediate de-phasing of sequencing analyses employing pyrosequencing or other “sequencing by synthesisâ€? methods.

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    合成参考文献


    摘要:Nakao, Y., Science of Synthesis: Catalytic Transformations via CH Activation, (2015) 1, 397.
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