CAS: 55272-86-1; 1-Cyano-2,3-Bis(2-(((4-Methyl-1H-Imidazol-5-yl)Methyl)Thio)Ethyl)Guanidine

英文名称1-Cyano-2,3-Bis(2-(((4-Methyl-1H-Imidazol-5-yl)Methyl)Thio)Ethyl)Guanidine
中文名称西咪替丁EP杂质F
其它别名Cimetidine Impurity 6; Cimetidine Impurity F; Cimetidine Ep Impurity F; Cimetidine Impurity 6（cimetidine Ep Impurity F）; Cimetidine Impurity 6/cimetidine Ep Impurity F/cimetidine Bis Impurity/2-Cyano-1,3-Bis[2-[[(5-Methyl-1H-Imidazol-4-yl)Methyl]-Sulfanyl]Ethyl] Guanidine; N-Cyano-N’,N”-Bis[2-[[(5-Methyl-1H-Imidazol-4-yl)Methyl]Thio]Ethyl]Guanidine; Guanidine, N-Cyano-N',N''-Bis[2-[[(5-Methyl-1H-Imidazol-4-yl)Methyl]Thio]Ethyl]-; N-Cyano-N',N''-Bis-[2-((5-Methyl-4-Imidazolyl)Methylthio)-Ethyl]Guanidine
CAS编号55272-86-1
FDA UNII编号:ZWM4XXL79G
分子式:C16H24N8S2分子量:392.56
产品CID: 2533608
产品分类分析化学 → 标准品 → 药典标准品和杂质标准品

相似结构搜索
InChIKey: OFGXKQGKIOVKQW-UHFFFAOYSA-N
InChI=1S/C16H24N8S2/c1-12-14(23-10-21-12)7-25-5-3-18-16(20-9-17)19-4-6-26-8-15-13(2)22-11-24-15/h10-11H,3-8H2,1-2H3,(H,21,23)(H,22,24)(H2,18,19,20)
计算化学: 氢键受体数6.0氢键供体数4.0可旋转键数12.0

MSDS等安全信息

警示词Danger
危险描述H318-
防范说明P280-P305+P351+P338+P310-
UN编号3077

上下游产品

N,N'-Bis-[2-((4-Methyl-5-Imidazolyl)Methylthio)Ethyl]Thiourea 55272-84-9
N-氰基-N-[2-(5-甲基咪唑-4-甲硫)乙基]-S-甲基异硫脲 N-Cyano-N'-<2-<(5-Methyl-4-Imidazolyl)-Methylthio>-Ethyl>-S-Methyl-Isothioharnstoff 52378-40-2
2-(((5-甲基-1H-咪唑-4-基)甲基)硫代)乙胺 4-Methyl-5-<(2-Aminoethyl)-Thiomethyl>-Imidazole 38585-67-0

合成工艺路线路线简述

38585-67-0 + 10191-60-3 = 55272-86-1
反应条件:1.1
标题:Synthesis And H2-Antihistaminic Activity Of N,N'-Bisimidazole Substituted Thioureas,Cyanoguanidines And 2-Nitro-1,1-Ethenediamines. 10. H2-Antihistaminics
作者:By Borchers,A. Et Al
参考文献:Arzneimittel-Forschung 日期:1982 卷标:32(12) 页码:1509-12

📜2-(((5-甲基-1H-咪唑-4-基)甲基)硫代)乙胺,N-氰亚胺基-S,S-二硫代碳酸二甲酯以吡啶作为反应溶剂,化学反应 6.0H,以35%的收率获得产物西咪替丁ep杂质f
参考文献:Borchers; Engler; Szelenyi,Arzneimittel-Forschung/drug Research,1982,Vol. 32,# 12,P. 1509-1512
标题:Borchers; Engler; Szelenyi,Arzneimittel-Forschung/drug Research,1982,Vol. 32,# 12,P. 1509-1512