CAS: 458-09-3; 3-Fluoro-4-Hydroxyphenylacetic Acid

该化合物是一种芳香化合物,其特点是在苯环上存在氟原子和氢氧基化合物,还有乙酸功能组,该化合物通常具有芳香和碳oxy酸两种功能的特性,包括由碳oxy酸组导致的潜在酸性;氟化物代成分能够影响化合物的再活性和极性,有可能增强其在极地溶剂中的溶性;氢氧基化合物有助于氢的结合能力,这可能影响其沸点和熔点;在应用方面,如3-Fluoro-4-氢氧苯乙酸化合物,由于其生物活动和结构特性,可能对制药或农用化学化学品感兴趣;此外,含电镀(氟化物)和乙酸(氢氧)组的存在可导致独特的电子电子特性,使其成为医学和材料科学的研究对象.

结构式图片

欧盟法规

ECHA物质C&L通报REACH预注册

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CAS号452-14-2 3-氟-4-甲氧基苯乙酸 | CAS号404-90-0 3-氟-4-甲氧基苯乙腈 | CAS号153003-19-1 3-Fluoro-4-hydr... | CAS号321-28-8 2-氟苯甲醚 | CAS号403-14-5 3'-氟-4'-羟基苯乙酮 | CAS号351-52-0 3-氟-4-甲氧基苄基氯 | CAS号367-12-4 2-氟苯酚 | CAS号345-72-2 3-氟-4-甲氧基苯甲酰基甲酸乙酯 | CAS号455-72-1 2-(3-fluoro-4-m... | CAS号628-13-7 吡啶盐酸盐 | CAS号444807-50-5 2-(4-氰基-3-氟苯基)乙酸甲酯 | CAS号5497-21-2 Benzeneethanol,...

合成工艺路线路线简述

    2-氟苯甲醚置于三氯化铝,一水合肼,硝基苯体系中,化学反应 2.0H,反应生成 3-氟-4-羟基苯乙酸
    参考文献:ber Die Synthese Von 3-Fluor-4-Oxy-Phenylessigsure
    标题:ber Die Synthese Von 3-Fluor-4-Oxy-Phenylessigsure
    摘要:
    DOI:10.1007/bf00903640

    海关参考信息

    专利信息


    专利号:US-8420850-B2
    优先权日:2010-05-14
    标 题:Compounds for the synthesis of biostable polyurethane, polyurea or polyurea urethane polymers
    发明人:DUOCASTELLA CODINA LLUIS; MOLINA MARIA; ARAD OFIR; BORRELL BILBAO JOSE IGNACIO; GARCIA DAVID SANCHEZ; PETTERSON SALOM SOFIA HENRIETTE
    权利人:DUOCASTELLA CODINA LLUIS; MOLINA MARIA; ARAD OFIR; BORRELL BILBAO JOSE IGNACIO; GARCIA DAVID SANCHEZ; PETTERSON SALOM SOFIA HENRIETTE; IBERHOSPITEX SA
    摘要:The invention comprises compounds which are derived from a drug or a substance with therapeutic properties, and useful as reagents for the synthesis of biostable polymers including said drug in their backbone, namely polyurethanes, polyureas or polyurea urethanes that are biocompatible and biostable. The invention also comprises the processes for preparing the compounds and the polymers, and to the use of these polymers for the manufacture of medical devices.

    专利号:US-6531470-B1
    优先权日:1998-01-23
    标题:Oxazolidinone combinatorial libraries, compositions and methods of preparation
    发明人:GORDEEV MIKHAIL F; LUEHR GARY W; PATEL DINESH V; NI ZHI-JIE; GORDON ERIC
    权利人:UPJOHN CO
    摘要:Oxazolidinones and methods for their synthesis are provided. Also provided are combinatorial libraries comprising oxazolidinones, and methods to prepare the libraries. Further provided are methods of making biologically active oxazolidinones as well as pharmaceutically acceptable compositions comprising the oxazolidinones. The methods of library preparation include the attachment of oxazolidinones to a solid support. The methods of compound preparation in one embodiment involve the reaction of an iminophosphorane with a carbonyl containing polymeric support.

    专利号:US-6562844-B2
    优先权日:1998-01-23
    标 题:Oxazolidinone combinatorial libraries, compositions and methods of preparation
    发明人:GORDEEV MIKHAIL F; LUEHR GARY W; PATEL DINESH V; NI ZHI-JIE; GORDON ERIC
    权利人:UPJOHN CO
    摘要:Oxazolidinones and methods for their synthesis are provided. Also provided are combinatorial libraries comprising oxazolidinones, and methods to prepare the libraries. Further provided are methods of making biologically active oxazolidinones as well as pharmaceutically acceptable compositions comprising the oxazolidinones. The methods of library preparation include the attachment of oxazolidinones to a solid support. The methods of compound preparation in one embodiment involve the reaction of an iminophosphorane with a carbonyl containing polymeric support.

    专利号:US-2012059117-A1
    优先权日:2010-05-14
    标 题 :Compounds for the synthesis of biostable polyurethane, polyurea or polyurea urethane polymers

    专利号:US-9217012-B2
    优先权日:2009-04-08
    标题 :Inhibitors of protein tyrosine phosphatases
    发明人:ZHANG ZHONG-YIN; ZHANG SHENG
    权利人:ZHANG ZHONG-YIN; ZHANG SHENG; UNIV INDIANA RES & TECH CORP
    摘要:Disclosed herein are compounds that selectively inhibit members of the PTP family of enzymes. Synthesized compounds demonstrated selective inhibition of TC-PTP. Also provided are methods of using the compounds and formulations containing the compounds. Also described is a fluorescence-tagged combinatorial library synthesis and screening method. And methods of using these compounds to effect enzyme activity both in cells and in vitro as well as method of using these compounds to treat diseases in human and animals.

    专利号:WO-2011141341-A1
    优先权日:2010-05-14
    标题:Compounds for the synthesis of biostable polyurethane, polyurea or polyurea urethane polymers
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    主要参考文献

    [参考文献]: S Jordan, Et Al. An In Vivo Microdialysis Study Of Striatal 6-[18F]Fluoro-L-M-Tyrosine Metabolism. Neurochem Res. 1998 Apr;23(4):513-7.

    合成参考文献


    参考文献:10.1007/bf02191886
    摘要:Koponen HJ, Lepola U, Leinonen E. A long-term follow-up study of cerebrospinal fluid 5-hydroxyindoleacetic acid in delirium. European Archives of Psychiatry and Clinical Neuroscience. 1994 Sep;244(3):131–4. doi: 10.1007/bf02191886.
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