CAS: 443642-30-6; α-D-Erythro-Pentofuranosid-2-Ulose, Methyl 3,5-Bis-O-[(2,4-Dichlorophenyl)Methyl]-

英文名称α-D-Erythro-Pentofuranosid-2-Ulose, Methyl 3,5-Bis-O-[(2,4-Dichlorophenyl)Methyl]-
中文名称1-O-甲基-3,5-二-O-[(2,4-二氯苯基)甲基]-α-D-赤式戊呋喃糖苷-2-酮
IUPAC名称(2S,4R,5R)-4-((2,4-dichlorobenzyl)oxy)-5-(((2,4-dichlorobenzyl)oxy)methyl)-2-methoxydihydrofuran-3(2H)-one
其它别名1-O-Methyl-3,5-Bis-O-[(2,4-Dichlorophenyl)Methyl]-Alpha-D-Erythro-Pentofuranoside-2-Ulose; 1-O-Methyl-3,5-Bis-O-[(2,4-Dichlorophenyl)Methyl]-Alpha-D-Erthro-Pentofuranoside-2-Ulose; A-D-Erythro-Pentofuranosid-2-Ulose,; Methyl 3,5-Bis-O-(2,4-Dichlorobenzyl)-α-D-Erythro-Pentofuranosid-2-Ulose; 1-O-Methyl-3,5-Bis-O-[(2,4-Dichlorophenyl)Methyl]-α-D-Erthro-Pentofuranoside-2-Ulose; α-D-Erythro-Pentofuranosid-2-Ulose, Methyl 3,5-Bis-O-[(2,4-Dichlorophenyl)Methyl]-; Methyl 3,5-Di-O-(2,4-Dichlorobenzyl)-2-Keto-A-D-Ribofuranoside; 3,5-Bis-O-(2,4-Dichlorophenylmethyl)-1-O-Methyl-α-D-Erythro-Pentafuranos-2-Ulose
CAS编号443642-30-6
MFCD编号:MFCD08703331
分子式:C20H18Cl4O5分子量:480.17
产品CID: 1451692
产品分类生物化工 → 糖类化合物 → 单糖

相似结构搜索
InChIKey: VRMGHTPUUVWQSN-RLLQIKCJSA-N
InChI=1S/C20H18Cl4O5/c1-26-20-18(25)19(28-9-12-3-5-14(22)7-16(12)24)17(29-20)10-27-8-11-2-4-13(21)6-15(11)23/h2-7,17,19-20H,8-10H2,1H3/t17-,19-,20+/m1/s1
计算化学: 氢键受体数5.0氢键供体数*可旋转键数8.0

MSDS等安全信息

上下游产品

(3R,4S,5R)-4-((2,4-dichlorobenzyl)oxy)-5-(((2,4-dichlorobenzyl)oxy)methyl)-2-methoxytetrahydrofuran-3-ol (2R,3R,4R)-3,4-bis((2,4-dichlorobenzyl)oxy)-2-(((2,4-dichlorobenzyl)oxy)methyl)-5-methoxytetrahydrofuran 2-O-acetyl-3,5-bis-O-(2,4-dichlorophenylmethyl)-1-O-methyl-α-D-ribofuranose 3,5-bis-O-(2,4-dichlorophenylmethyl)-2-C-ethyl-1-O-methyl-α-D-ribofuranose (2S,3R,4R,5R)-4-((2,4-dichlorobenzyl)oxy)-5-(((2,4-dichlorobenzyl)oxy)methyl)-2-methoxy-3-methyltetrahydrofuran-3-ol 7-deaza-2'-C-methyl-adenosine 4-chloro-5-methyl-7-(2-C-methyl-β-D-ribofuranosyl)-7H-pyrrolo[2,3-d]pyrimidine

合成工艺路线路线简述

合成目标产物 1-O-Methyl-3,5-Bis-O-[(2,4-Dichlorophenyl)Methyl]-Alpha-D-Erthro-Pentofuranoside-2-Ulose 主要起始原料 1-Methyl-3,5-Bis-O-(2,4-Dichlorobenzyl)-Alpha-D-Ribofuranoside
(文献来源)合成步骤主要原料 1-Methyl-3,5-Bis-O-(2,4-Dichlorobenzyl)-Alpha-D-Ribofuranoside

📜Methyl 2,3,5-Tri-O-(2,4-Dichlorobenzyl)-D-Ribofuranoside置于三氯异氰尿酸,四氯化锡体系中,用二氯甲烷作为反应溶剂,化学反应 6.17H,反应生成 1-O-甲基-3,5-二-O-[(2,4-二氯苯基)甲基]-Alpha-D-赤式戊呋喃糖苷-2-酮
参考文献:Discovery Of 2'-α-C-Methyl-2'-β-C-Fluorouridine Phosphoramidate Prodrugs As Inhibitors Of Hepatitis C Virus
标题:Discovery Of 2'-α-C-Methyl-2'-β-C-Fluorouridine Phosphoramidate Prodrugs As Inhibitors Of Hepatitis C Virus
摘要:2'-Alpha-C-Methyl-2'-Beta-C-Fluorouridine And Its Phosphoramidate Prodrugs Were Synthesized And Evaluated For Their Inhibitory Activity Against Hcv. The Structure-Activity Relationship Analysis Of The Phosphoramidate Moiety Found That 17M,17Q,And 17R Exhibit Potent Activities Against Hcv,With Ec50 Values Of 1.82 +/-0.19,0.88 +/-0.12,And 2.24 +/-0.22 Mu M,Respectively. The Docking Study Revealed That The Recognition Of The 2'-Beta-F By Arg158,3'-Oh By N291,And The Watson Crick Pairing With The Template Allowed 23 To Form The In-Line Conformation Necessary For Its Incorporation Into The Viral Rna Chain.
DOI:10.1021/acsmedchemlett.6B00270