CAS: 329-98-6; Phenylmethanesulfonyl Fluoride

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苄磺酰氯置于potassium Fluoride,水体系中,用54%的收率获得产物苯甲基磺酰氟
参考文献:Flash Vacuum Pyrolysis Of Stabilised Phosphorus Ylides. Part 12.1 Extrusion Of Ph3P From Sulfonyl Ylides And Reactivity Of The Resulting Sulfonyl Carbenes
标题:Flash Vacuum Pyrolysis Of Stabilised Phosphorus Ylides. Part 12.1 Extrusion Of Ph3P From Sulfonyl Ylides And Reactivity Of The Resulting Sulfonyl Carbenes
摘要:已制备十二种磺酰稳定的磷亚叶立德,并研究了它们在600 oc下的快速真空热解行为.带有芳基磺酰取代基的例子会失去ph3Po,产生难以处理的产物,而带有芳基甲基磺酰取代基的则分别失去ph3P和so2,反应生成与磺酰烯烃中间体一致的产物.对每个系列中一种亚叶立德的x射线结构测定显示,第一种情况下p-o之间的非键合相互作用更为显著,这为不同的热反应性提供了一些解释.
DOI:10.1039/a707948F

专利信息

专利号:US-2012190064-A1
优先权日:2004-10-01
标题 :Feeding buffers, systems, and methods for in vitro synthesis of biomolecules
发明人：KUDLICKI WIESLAW ANTONI; KEPPETIPOLA SHIRANTHI; FLETCHER JULIA; GETBEHEAD ASHLEY ELAINE; KATZEN FEDERICO; VOZZA-BROWN LAURA
权利人:KUDLICKI WIESLAW ANTONI; KEPPETIPOLA SHIRANTHI; FLETCHER JULIA; GETBEHEAD ASHLEY ELAINE; KATZEN FEDERICO; VOZZA-BROWN LAURA; LIFE TECHNOLOGIES CORP
摘要:Compositions, methods and kits for in vitro systems for synthesis of biomolecules such as polypeptides, are provided herein. Cell extracts that provide enhanced yields of soluble proteins using in vitro protein synthesis methods are provided. The invention also includes methods for producing high yields of proteins by the addition of a feeding solution that includes amino acids and an energy source to an ongoing in vitro synthesis system. The invention also includes methods of using a high-yield in vitro synthesis system to produce large quantities of proteins with incorporated labeled amino acids for analysis by methods such as by NMR. The invention further includes vectors for enhanced production of proteins from nucleic acid templates using in vitro synthesis systems.

专利号:EP-1309698-B1
优先权日:2000-07-21
标 题:A cytochrome p450 enzyme associated with the synthesis of delta-12 -epoxy groups in fatty acids of plants
发明人：CAHOON EDGAR B
权利人:DU PONT
摘要:An isolated nucleic acid fragment encoding a cytochrome P450 enzyme associated with the synthesis of plant DELTA12-epoxy fatty acids is disclosed. The invention also relates to making a chimeric construct encoding all or a portion of the cytochrome P450 enzymes associated with the synthesis of plant DELTA12-epoxy fatty acids, in sense or antisense orientation, wherein expression of the chimeric construct results in production of altered levels of the cytochrome P450 enzymes associated with the synthesis of plant DELTA12-epoxy fatty acids in a transformed host cell.

专利号:US-5939304-A
优先权日:1997-06-05
标题:Method for synthesis of anhydrothrombin
发明人：SUZUKI TOYOAKI; HOSOKAWA KAZUYA; NAGATA MASANORI
权利人:FUJIMORI KOGYO CO
摘要:A method for a synthesis of anhydrothrombin is provided which features a short process, an easy procedure, and high yields. n The method comprises n (A) a step of causing an active serine residue site of thrombin to react with an inhibitor, n (B) a step of performing an alkali treatment at a pH of not less than 11, and n (C) a step of performing an operation of recovery, and carries out these steps sequentially in the order mentioned, and is characterized by causing at least the step of performing the operation of recovery to proceed in the presence of at least one compound selected from the group consisting of polyhydric alcohols and saccharides, and a salt or an amphoteric electrolyte.

专利号:WO-2024030092-A1
优先权日:2022-08-01
标 题:Synthesis of protein-based nanoparticular systems
发明人：GOKCE ISA; KAPLAN OZLEM; ARDA EMINE SEKURE NAZLI; PABUCCUOGLU SAADET KEVSER; GOK MEHMET KORAY
权利人:ISTANBUL UNIV CERRAHPASA REKTORLUGU; GOKCE ISA; ISTANBUL UNIV REKTORLUGU
摘要:The present invention relates to protein-based nanoparticles, synthesis of these nanoparticles and their use in cancer therapy for improving the stabilization and cellular uptake of MS1 peptide that specifically binds to and inhibits Mcl-1 protein. In the present invention, a novel fusion protein design has been realized to induce apoptosis in cancer cells. Said fusion protein consists of three parts. The first part is an antiapoptotic inhibitory cationic peptide (MS1 peptide) targeting the BH3 domain of the MCL-1 protein, the second part is a fluorescent protein, and the third part is a peptide containing the amino acid histidine. This engineered protein was expressed and successfully purified by using recombinant DNA technology. Self-assembled protein-based nanoparticles were obtained from the fusion protein produced with the present invention, and the characterization of the nanoparticles was performed. This protein was also encapsulated into PLGA- PBAE based hybrid polymeric nanoparticles and the characterization of the produced nanoparticles was performed. Nanoparticular systems produced by the present invention showed selective cytotoxic effect against cancer cell line with high MCL-1 expression compared to healthy cell line and induced apoptosis in these cells.

专利号:WO-2013066264-A1
优先权日:2011-10-31
标题:Enzymatic synthesis of cyclic and linear diadenosine monophosphate
发明人：LIANG ZHAOXUN; PASUNOOTI SWATHI
权利人:UNIV NANYANG TECH
摘要:The present invention relates to polypeptides for the enzymatic synthesis of cyclic diadenosine monophosphate (c-di-AMP) and linear diadenosine monophosphate (5'-pApA) and nucleic acids encoding these polypeptides as well as cells comprising these nucleic acids. The present invention also relates to the recombinant production of the polypeptides of the invention and methods of synthesizing c-di-AMP and/or 5'-pApA using said polypeptides.

专利号:US-5352670-A
优先权日:1991-06-10
标题:Methods for the enzymatic synthesis of alpha-sialylated oligosaccharide glycosides
发明人：VENOT ANDRE P; UNGER FRANK M; KASHEM MOHAMMED A; BIRD PAUL; MAZID M ABDUL
权利人:ALBERTA RES COUNCIL
摘要:Disclosed are methods for the enzymatic synthesis of alpha-sialylated oligosaccharide glycosides. Specifically, in the disclosed methods, sialyltransferase is activated to transfer an analogue of sialic acid, employed as its CMP-nucleotide derivative, to an oligosaccharide glycoside. The analogue of sialic acid and the oligosaccharide employed in this method are selected to be compatible with the sialyltransferase employed.