CAS: 29836-26-8; (2R,3S,4S,5R,6R)-2-(Hydroxymethyl)-6-(Octyloxy)Tetrahydro-2H-Pyran-3,4,5-Triol

该化合物是非离子表面活性剂和来自葡萄糖的胶质,其特点是八碳烷基链,与-D-甘基丙烷甘蓝的亚美色碳相连,其特征为非光学性,具有水利(葡萄糖)和疏水(辛基链)特性,使其在诸如溶剂,乳化剂和生物化学和制药配方中稳定剂等各种应用中有用,通常是白色到白的固体或粘粘液,取决于温度和纯度.该物质在有机溶剂中溶解,其水溶性有限,对烷基胶质具有常见性.其表面活化特性使其能降低溶液表面的紧张性,便利了液态物质的传播.此外,生物研究中经常使用1-O-o-octyl-d-glucopromaclaus,特别是涉及氨基蛋白质和细胞分泌物的研究.

结构式图片

相似化合物

29781-80-4 38954-67-5 140147-38-2

欧盟法规

ECHA物质C&L通报REACH预注册

上下游产品

CAS号38954-67-5 辛基-2,3,4,6-四-O-... | CAS号2280-44-6 D-glucopyranose | CAS号111-87-5 正辛醇 | CAS号1464-44-4 苯基-β-D-葡萄糖苷 | CAS号185549-56-8 °Ctyl 3,4,6-tri... | CAS号55628-54-1 3,4,6-三苄氧基-D-葡萄烯糖 | CAS号133-99-3 D(+)-纤维二糖 | CAS号50-99-7 D(+)-无水葡萄糖 | CAS号604-69-3 β-D-葡萄糖五乙酸酯 | CAS号38954-67-5 辛基-2,3,4,6-四-O-... | CAS号492-61-5 β-D-葡萄糖 | CAS号111-87-5 正辛醇

合成工艺路线路线简述

  • 合成目标产物 N-Octyl-β-D-Glucopyranoside 主要起始原料 1-Octanol And D(+)-Glucose
  • (文献来源)合成步骤主要原料 1-Octanol 和 D(+)-Glucose
戊基beta-D-吡喃葡萄糖苷置于almond Meal体系中,用 水 用作溶剂,化学反应 336.0H,反应生成N-辛基-β-D-吡喃葡萄糖苷
参考文献:Significantly Improved Equilibrium Yield Of Long-Chain Alkyl Glucosides Via Reverse Hydrolysis In A Water-Poor System Using Cross-Linked Almond Meal As A Cheap And Robust Biocatalyst
标题:Significantly Improved Equilibrium Yield Of Long-Chain Alkyl Glucosides Via Reverse Hydrolysis In A Water-Poor System Using Cross-Linked Almond Meal As A Cheap And Robust Biocatalyst
摘要:An Array Of Ten Beta-D-Glueopyranosides With Varied Alkyl Chain Lengths Were Enzymatically Synthesized. It Was Found That For Longer Alkyl Chains A Lower Initial Rate And Final Yield Of Glucoside Was Obtained Except For Methyl Glucoside Because Of The Severe Toxicity Of Methanol To The Enzyme. From A Thermodynamics Point Of View,The Equilibrium Constant And Gibbs Free Energy Variation Of The Glucoside Syntheses Were Systematically Investigated. To Improve The Final Yields Of The Glucosides Containing Long Alkyl Chains The Equilibrium Of The Enzymatic Glucoside Synthesis Was Altered. The Equilibrium Yield Of Decyl Beta-D-Glucoside Increased From 1.9% To 6.1% When The Water Content Was Reduced From 10% To 5% (V/v) Using Tert-Butanol As A Cosolvent And 0.10 Mol/l Of Glucose As A Substrate. As For The Other Longer Alkyl Chain Glucosides,Heptyl Beta-D-Glucoside Was Found To Have Significant Surface Activity As Well.
Doi:10.1016/s1872-2067(11)60333-1

海关参考信息

专利信息


专利号:US-2012190064-A1
优先权日:2004-10-01
标题 :Feeding buffers, systems, and methods for in vitro synthesis of biomolecules
发明人:KUDLICKI WIESLAW ANTONI; KEPPETIPOLA SHIRANTHI; FLETCHER JULIA; GETBEHEAD ASHLEY ELAINE; KATZEN FEDERICO; VOZZA-BROWN LAURA
权利人:KUDLICKI WIESLAW ANTONI; KEPPETIPOLA SHIRANTHI; FLETCHER JULIA; GETBEHEAD ASHLEY ELAINE; KATZEN FEDERICO; VOZZA-BROWN LAURA; LIFE TECHNOLOGIES CORP
摘要:Compositions, methods and kits for in vitro systems for synthesis of biomolecules such as polypeptides, are provided herein. Cell extracts that provide enhanced yields of soluble proteins using in vitro protein synthesis methods are provided. The invention also includes methods for producing high yields of proteins by the addition of a feeding solution that includes amino acids and an energy source to an ongoing in vitro synthesis system. The invention also includes methods of using a high-yield in vitro synthesis system to produce large quantities of proteins with incorporated labeled amino acids for analysis by methods such as by NMR. The invention further includes vectors for enhanced production of proteins from nucleic acid templates using in vitro synthesis systems.

专利号:US-2023313255-A1
优先权日:2020-07-15
标题:Massively Parallel Enzymatic Synthesis of Polynucleotides
发明人:HORGAN ADRIAN; LACHAIZE HENRI; VERARDO DOMIANO; GODRON XAVIER
权利人:DNA SCRIPT
摘要:The invention is directed to methods and compositions for inkjet assisted synthesis of a plurality of polynucleotides at reaction sites on a substrate using template-free polymerases, such as, terminal deoxynucleotidyl transferases (TdTs). Compositions of the invention include formulations of synthesis reagents for inkjet delivery including, but not limited to, TdT coupling reaction buffers and 3′-O-protected dNTP monomers.

专利号:US-6451543-B1
优先权日:1998-08-31
标题:Lipid matrix-assisted chemical ligation and synthesis of membrane polypeptides
发明人:KOCHENDOERFER GERD G; HUNTER CHRISTIE L; KENT STEPHEN B H; BOTTI PAOLO
权利人:GRYPHON SCIENCES
摘要:The present invention relates to methods and compositions for lipid matrix-assisted chemical ligation and synthesis of membrane polypeptides that are incorporated in a lipid matrix. The invention is exemplified in production of a prefolded membrane polypeptide embedded within a lipid matrix via stepwise chemoselective chemical ligation of unprotected peptide segments, where at least one peptide segment is embedded in a lipid matrix. Any chemoselective reaction chemistry amenable for ligation of unprotected peptide segments can be employed. Suitable lipid matrices include liposomes, micelles, cell membrane patches and optically isotropic cubic lipidic phase matrices. Prefolded synthetic and semi-synthetic membrane polypeptides synthesized according to the methods and compositions of the invention also permit site-specific incorporation of one or more detectable moieties, such as a chromophore, which can be conveniently introduced during synthesis. The methods and compositions of the invention have multiple uses. For example, they can be used to assay ligand binding to membrane polypeptides and domains comprising a receptor, and thus are extremely useful for structure/function studies, drug screening/selection/design, and diagnostics and the like, including high-throughput applications. The methods and compositions of the invention are particularly suited for FRET analyses of previously inaccessible membrane polypeptides.

专利号:US-2006211083-A1
优先权日:2005-01-21
标题:Products and processes for in vitro synthesis of biomolecules
发明人:KATZEN FEDERICO; KUDLICKI WIESLAW; FLETCHER JULIA
权利人:KATZEN FEDERICO; KUDLICKI WIESLAW; FLETCHER JULIA
摘要:Provided herein are products and processes for efficiently synthesizing biomolecules in vitro using cell-free extracts derived from mammalian cells and insect cells. In an embodiment, provided is a process for preparing a cell-free extract from insect cells and mammalian cells that efficiently synthesizes post-translationally modified target proteins (e.g., glycosylated target proteins). In some embodiments, a ribonucleic acid is synthesized in vitro that comprises a cap, a 5′ untranslated region comprising an 18S rRNA binding ribonucleotide sequence, and a target ribonucleotide sequence. It has been determined that such ribonucleic acids result in efficient in vitro synthesis of a target protein using cell-free extracts derived from non-rabbit mammalian cells and insect cells.

专利号:US-4739043-A
优先权日:1984-07-19
标题 :Method for the synthesis of alkyl, cycloalkyl or alcenyl aldosides or polyaldosides
发明人:DEFAYE JACQUES; WONG EMILE; PEDERSEN CHRISTIAN; CHEDIN JEAN; BOUCHU ALAIN
权利人:BEGHIN SAY SA
摘要:PCT No. PCT/FR85/00197 Sec. 371 Date Apr. 18, 1986 Sec. 102(e) Date Apr. 18, 1986 PCT Filed Jul. 18, 1985 PCT Pub. No. WO86/00906 PCT Pub. Date Feb. 13, 1986.The process comprises the action of a saturated aliphatic or cycloaliphatic alcohol or an aliphatic or cycloaliphatic alcohol comprising a double ethylenic bound not situated in alpha of the hydroxyl group with an aldose, aldoside or polyaldoside in the solvent and reactant formed by the hydrogen fluoride. Application to the synthesis of surfactants or as additives for rigidifying polyurethane foams.

专利号:US-6268534-B1
优先权日:1998-02-23
标 题 :Process for the synthesis of N,N-Dioleyl-N,N-Dimethylammonium Chloride
发明人:MATULIC-ADAMIC JASENKA
权利人:RIBOZYME PHARM INC
摘要:A novel process for the synthesis of N,N-dioleyl-N,N-dimethylammonium chloride (DODAC) is described
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主要参考文献

[参考文献]: Gould Rj, Et Al. Effects Of Octyl Beta-Glucoside On Insulin Binding To Solubilized Membrane Receptors. Biochemistry. 1981 Nov 24;20(24):6776-81.
[参考文献]: Konidala P, Et Al. Molecular Dynamics Characterization Of N-Octyl-Beta-D-Glucopyranoside Micelle Structure In Aqueous Solution. J Mol Graph Model. 2006 Sep;25(1):77-86.
[参考文献]: Joana A Loureiro, Et Al. Charged Surfactants Induce A Non-Fibrillar Aggregation Pathway Of Amyloid-Beta Peptide. J Pept Sci. 2013 Sep;19(9):581-7.
[参考文献]: Jürgen Borlak, Et Al. Proteome Mapping Of Epidermal Growth Factor Induced Hepatocellular Carcinomas Identifies Novel Cell Metabolism Targets And Mitogen Activated Protein Kinase Signalling Events. Bmc Genomics. 2015 Feb 25;16(1):124.
[参考文献]: Luke L Lairson, Et Al. Using Substrate Engineering To Harness Enzymatic Promiscuity And Expand Biological Catalysis. Nat Chem Biol. 2006 Dec;2(12):724-8.

合成参考文献


参考文献:10.1007/s10863-011-9364-5
摘要:Pagadala V, Vistain L, Symersky J, Mueller DM. Characterization of the mitochondrial ATP synthase from yeast Saccharomyces cerevisae. Journal of Bioenergetics and Biomembranes. 2011 Jul 12;43(4):333. doi: 10.1007/s10863-011-9364-5.
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