CAS: 2941-78-8; 2-Amino-5-Methylbenzoic Acid

上下游产品

CAS号3113-72-2 5-甲基-2-硝基苯甲酸 | CAS号614-96-0 5-甲基吲哚 | CAS号6492-69-9 5,5'-Dimethyl-Δ... | CAS号608-05-9 5-甲基靛红 | CAS号99-04-7 间甲基苯甲酸 | CAS号5925-93-9 2-氨基-5-甲基苯腈 | CAS号620-22-4 间甲基苯腈 | CAS号33900-97-9 2,4-dioxo-3-(p-... | CAS号7342-77-0 1,3-di(4-tolyl)... | CAS号64407-07-4 间氰基氯苄 | CAS号106324-53-2 6-methyl-2-(tri... | CAS号106585-70-0 2-Desamino-5,8-... | CAS号58677-05-7 2-氨基-5-甲基苯甲酸乙酯 | CAS号39576-82-4 2,4-二氯-6-甲基喹唑啉 | CAS号34897-84-2 2-氨基-5-甲基苯甲醇 | CAS号58530-13-5 3-溴-5-甲基苯甲酸 | CAS号40545-33-3 2-氨基-5-甲基苯甲酰胺 | CAS号50440-82-9 2-氨基-6-甲基-4(3H)-喹唑啉酮 | CAS号18731-19-6 2,6-二甲基喹唑啉酮 | CAS号4692-99-3 6-甲基靛红酸酐

间甲基苯腈置于盐酸,Tin,硝酸体系中,化学反应生成2-氨基-5-甲基苯甲酸
参考文献:Findeklee,Chemische Berichte,1905,Vol. 38,P. 3555
标题:Findeklee,Chemische Berichte,1905,Vol. 38,P. 3555

专利信息

专利号:US-5783577-A
优先权日:1995-09-15
标题 :Synthesis of quinazolinone libraries and derivatives thereof
发明人：HOUGHTEN RICHARD A; OSTRESH JOHN M
权利人:TREGA BIOSCIENCES INC
摘要:The present invention provides synthetic combinatorial libraries of organic compounds based on the quinazolinone ring.

专利号:US-6187923-B1
优先权日:1998-11-09
标题 :Process for the synthesis of quinazolinones
发明人：DENER JEFFREY MARK; LY CUONG QUOC
权利人:AXYS ADVANCED TECHNOLOGIES INC
摘要:The present invention provides a process for synthesizing a compound or a library of compounds of Formula 1A and 1B:

专利号:US-4308206-A
优先权日:1980-03-17
标 题:Process for preparing derivatives of 5,11-dihydro-6h-pyrido[2,3-b][1,4]-benzodiazepin-6-one, and the final derivatives and synthesis intermediates obtained thereby
发明人：GERSZBERG SZEPSEL
权利人:MICROSULES ARGENTINA SA
摘要:This invention relates to a process for preparing derivatives of 5,11-dihydro-6H-pyrido[2,3-b][1,4]-benzodiazepin-6-one of general formula (I) ##STR1## in which R is hydrogen, halogen or methyl; n R 1 and R 2 are linear or branched C 2 -C 4 alkyl groups, which alternatively may be joined together to give a piperazine cycle which can be substituted in position 4 with a methyl, ethyl or benzyl group, n and their salts with organic and inorganic acids, characterised by comprising the following stages: n (a) reacting a compound of general formula (X), ##STR2## in which R has the meaning heretofore defined, with 2-cloro-3-amino-pyridine of formula (III) ##STR3## in the presence of polyphosphoric acid, to give an intermediate of general formula (II) ##STR4## (b) reacting said intermediate with a compound of general formula (XI) ##STR5## in which R 1 and R 2 have the meaning heretofore defined and R 3 is a hydroxyl or halogen, in an inert solvent at a maximum temperature equal to the solvent boiling point, to give said derivatives of general formula (I). n The invention also relates to the final compounds thus obtained, and the synthesis intermediates obtained during the course of said process. n The final products of formula (I) are of great interest in the pharmaceutical field.

专利号:WO-0027831-A1
优先权日:1998-11-09
标题 :Process for the synthesis of quinazolinones

专利号:US-2011263569-A1
优先权日:2007-08-22
标 题 :Ryanodine channel binders and uses thereof
发明人：COREY ELIAS JAMES
权利人:HARVARD COLLEGE
摘要:Increasing the affinity of calstabin-2 for the cardiac calcium channel RyR2 and thereby stabilizing the channel in the closed state has recently been identified as novel mechanism for treating heart failure, particularly ventricular arrhythmias. JTV-519, a 1,4-benzothiazepine derivative, has been shown to stabilize the calstabin2/RyR2 complex. Novel derivatives of JTV-519 that may be useful in treatment or prevention of heart failure, atrial fibrillation, or exercise-induced cardiac arrhythmias are provided. Synthetic methodology and intermediates in the synthesis of the inventive JTV-519 derivatives are also described.

专利号:WO-9811438-A1
优先权日:1996-09-13
标题 :Synthesis of quinazolinone libraries and derivatives thereof