CAS: 2752-64-9; (3R,4R,6S,6As,7R,7Ar,8R,9R,10S,11S,11Ar,12R,12Ar,13R,14S)-11A-Acetoxy-4,9,11-Trihydroxy-6,10,13-Trimethoxy-3-(Methoxymethyl)-1-Methyltetradecahydro-2H-3,6A,12-(Epiethane[1,1,2]Triyl)-7,9-Methanonaphtho[2,3-B]Azocin-8-Yl Benzoate
该化合物是一种复杂的有机化合物,属于来自非对称物种的类藻类.该物质具有多种功能组,包括混合氧和乙酸糖,有助于其化学反应和潜在的生物活动.多种氢氧化合物的存在表明,它可能表现出氢联结能力,影响其溶性以及与生物系统的互动.对同源衍生物衍生物的化学特性,包括潜在的厌食和抗炎效应,经常对其进行研究.然而,由于许多亚甲酸盐类具有毒性,因此必须认真处理和彻底了解其生物影响.这一化合物的结构复杂性表明,它可能具有独特的立体化学特性,从而影响其与生物目标的相互作用.进一步研究对于充分阐明其化学特性和潜在化学影响是有必要的.
- 英文名称(3R,4R,6S,6As,7R,7Ar,8R,9R,10S,11S,11Ar,12R,12Ar,13R,14S)-11A-Acetoxy-4,9,11-Trihydroxy-6,10,13-Trimethoxy-3-(Methoxymethyl)-1-Methyltetradecahydro-2H-3,6A,12-(Epiethane[1,1,2]Triyl)-7,9-Methanonaphtho[2,3-B]Azocin-8-Yl Benzoate
- 中文名称中乌头碱
- IUPAC名称(3R,4R,6S,6aR,7R,7aR,8R,9R,10S,11S,11aR,12R,12aR,13R,14S)-11a-acetoxy-4,9,11-trihydroxy-6,10,13-trimethoxy-3-(methoxymethyl)-1-methyltetradecahydro-2H-3,6a,12-(epiethane[1,1,2]triyl)-7,9-methanonaphtho[2,3-b]azocin-8-yl benzoate
- 其它别名Mesaconitine(6CI,7CI,8CI); 2H-12,3,6a-Ethanylylidene-7,9-methanonaphth[2,3-b]az°Cine,aconitane-3,8,13,14,15-pentol deriv.
- CAS编号2752-64-9
- MFCD编号:MFCD00210528
- EINECS号:220-397-6
- FDA UNII编号:621OT356HL
- 分子式:C33H45NO11分子量:631.72
- 产品CID: 1255234
- 产品分类生物化工 → 中草药成分
物理性质
MSDS等安全信息
- GHS象形图
- GHS符号GHS06;
注释: Skull and crossbones - 危险类别急性毒性 类别1(吸入)
急性毒性 类别1(经口) - 警示词Danger(危险)
- 危险描述H330 |吸入致命.
H300 |吞咽致命. - 防范说明P264Thoroughly clean after treatmentP280Wear protective gloves/Wear protective clothing/Wear protective goggles/Wear a protective maskP305If it enters the eyesP351Rinse carefully with water for a few minutesP338Remove the contact lens(If any)And easy to operate,Continue flushingP337If eye irritation persistsP313Obtain medical advice/care
- 危险等级6.1(a)
- UN编号1544
- 危险品标志Xn
- 包装等级I
- 安全声明24/25
欧盟法规
C&L通报REACH预注册上下游产品
CAS号3327-35-3 N-desethylaconitine | CAS号74-88-4 碘甲烷 | CAS号302-27-2 乌头碱 | CAS号6900-87-4 次乌头碱合成工艺路线路线简述
海关参考信息
- 2905122000-异丙醇
2905143000-叔丁醇
2905310000-1,2-乙二醇
2905320000-1,2-丙二醇 - 💡 提示：海关信息按照顺序优先匹配，如需确认的海关信息，请参考相关资料。
- 详情请参考：📖 海关编码查询和海关进出口税则
供应商参考报价(招募中)
品牌试剂参考报价(招募中)
📌 第三方产品分析报告
主要参考文献
1: Fan B, Xu S, Bi J, Huang S, Zu Z, Qian C. Simultaneous Determination of Six Alkaloids in Rat Plasma by SPE-HPLC-MS/MS and Their Pharmacokinetics after Oral Administration of Radix aconiti Preparata Extract. ACS Pharmacol Transl Sci. 2020 Dec 6;4(1):118-127. doi: 10.1021/acsptsci.0c00133.
2: Shi Y, Zhao Y, Qian J, Dong Z, Wen G, Zhao D, Kennelly EJ. Aconitum Diterpenoid Alkaloid Profiling to Distinguish between the Official Traditional Chinese Medicine (TCM) Fuzi and Adulterant Species Using LC-qToF-MS with Chemometrics. J Nat Prod. 2021 Jan 26. doi: 10.1021/acs.jnatprod.0c00851. Epub ahead of print. 51(3):345-354. doi: 10.1080/00498254.2020.1866229. Epub 2021 Jan 5.
409:115332. doi: 10.1016/j.taap.2020.115332. Epub 2020 Nov 7.
合成参考文献
摘要:Yakugaku Zasshi. Journal of Pharmacy., 97(359), 1977 []
摘要:A15427: Ameri A: Effects of the Aconitum alkaloid mesaconitine in rat hippocampal slices and the involvement of alpha- and beta-adrenoceptors. Br J Pharmacol. 1998 Jan;123(2):243-50.
参考文献:10.1002/jms.1038
摘要:Kaneko R, Hattori S, Furuta S, Hamajima M, Hirata Y, Watanabe K, Seno H, Ishii A. Sensitive analysis of aconitine, hypaconitine, mesaconitine and jesaconitine in human body fluids and Aconitum tubers by LC/ESI-TOF-MS. J Mass Spectrom. 2006 Jun;41(6):810–4. doi: 10.1002/jms.1038.
参考文献:10.1016/j.ejphar.2003.10.022
摘要:Ogura J, Mitamura M, Someya A, Shimamura K, Takayama H, Aimi N, Horie S, Murayama T. Mesaconitine-induced relaxation in rat aorta: role of Na+/Ca2+ exchangers in endothelial cells. Eur J Pharmacol. 2004 Jan 12;483(2-3):139–46. doi: 10.1016/j.ejphar.2003.10.022.
参考文献:10.1002/pca.861
摘要:Jiang ZH, Xie Y, Zhou H, Wang JR, Liu ZQ, Wong YF, Cai X, Xu HX, Liu L. Quantification of Aconitum alkaloids in aconite roots by a modified RP-HPLC method. Phytochem Anal. 2005 Nov;16(6):415–21. doi: 10.1002/pca.861.
📝 需求与反馈
尽可能描述清楚需求与问题信息
