CAS: 26750-81-2; 5-Allyl-2-Hydroxy-N-(2-Hydroxyethyl)-3-Methoxybenzamide

上下游产品

3-methoxy-2-hydroxybenzaldehyde 3-methoxymethylsalicylate 2-hydroxy-3-methoxy-5-(2-propeny)benzoic acid, methyl ester ethanolamine

3-甲氧基水杨酸甲酯置于sodium Hydroxide体系中,用 丙酮,甲苯 用作溶剂,化学反应 25.0H,反应生成阿利苯多
参考文献:一种利胆药阿利苯多的制备方法
标题:一种利胆药阿利苯多的制备方法
摘要:本发明属于药物合成领域,提供了一种阿利苯多的制备方法,选择以2‑羟基‑3‑甲氧基苯甲醛为原料,选用高效的氧化酯化催化剂,一步氧化酯化得到2‑羟基‑3‑甲氧基苯甲酸甲酯,再在碱作用下,与烯丙基溴发生反应,生成2‑烯丙氧基‑3‑甲氧基苯甲酸甲酯,2‑烯丙氧基‑3‑甲氧基苯甲酸甲酯在高温下发生克莱森对位重排反应,得到2‑羟基‑3‑甲氧基‑5‑烯丙基苯甲酸甲酯,其在乙醇胺中发生胺解反应,生成阿利苯多.与传统的合成工艺相比,新工艺合成步骤简单,后处理较方便,产品质量好,易于实现工业化.

专利信息

专利号:US-7993390-B2
优先权日:2002-02-08
标 题:Implantable or insertable medical device resistant to microbial growth and biofilm formation
发明人：MILLER KATHLEEN M; BUCAY-COUTO WEENNA; LI JIANMIN
权利人:BOSTON SCIENT SCIMED INC
摘要:Disclosed are implantable or insertable medical devices that provide resistance to microbial growth on and in the environment of the device and resistance to microbial adhesion and biofilm formation on the device. In particular, the invention discloses implantable or insertable medical devices that comprise at least one biocompatible matrix polymer region, an antimicrobial agent for providing resistance to microbial growth and/or a microbial adhesion/biofilm synthesis inhibitor for inhibiting the attachment of microbes and the synthesis and accumulation of biofilm on the surface of the medical device. Also disclosed are methods of manufacturing such devices under conditions that substantially prevent preferential partitioning of any of said bioactive agents to a surface of the biocompatible matrix polymer and substantially prevent chemical modification of said bioactive agents.