CAS: 2280-85-5; 2-Amino-3-(6-Methyl-1H-Indol-3-yl)Propanoic Acid

该化合物是氨基酸锥虫的合成衍生物,在蛋白环的6个位置上有一个甲基组替代物,这一修改加强了其在生物化学和药理研究中的效用,特别是在涉及酶抑制,代谢途径和蛋白相互作用的研究中的效用.种族(DL)形式允许广泛适用于对立体生物活动的比较研究.它与自然锥虫的结构相似性使它成为调查试像新陈代谢和相关紊乱的有价值的探测器.该化合物通常用于改良的peptides合成,并用作进一步化学衍生的前体,为研究人员提供了机械和合成应用的多种工具.

结构式图片

上下游产品

4-[3-(6-methylindolyl)methyl]-4-hydroxy-2-hydroxyimino-glutalic acid ammonium salt 6-methyl-L-tryptophan 6-methyl-D-tryptophan

合成工艺路线路线简述

    📜Formylamino-(6-Methyl-Indol-3-Ylmethyl)-Malonic Acid Diethyl Ester 反应生成6-甲基-Dl-色氨酸
    参考文献:Batcho,A. D.;Hengartner,U. O.;Leimgruber,W.;Scott,D.;Valentine,D.,,+
    标题:Batcho,A. D.;Hengartner,U. O.;Leimgruber,W.;Scott,D.;Valentine,D.,,+

    海关参考信息

    专利信息


    专利号:US-2022298204-A1
    优先权日:2019-07-05
    标题 :Synthesis of a-amanitin and its derivatives
    发明人:SIEGERT MARY-ANN; KNITTEL CAROLINE HERTA; SÜSSMUTH RODERICH
    权利人:PURE BIOORGANICS SIA
    摘要:The present invention relates to the chemical synthesis of α-amanitin and its derivatives. The present invention also relates to intermediate products of the α-amanitin synthesis.

    专利号:US-12351573-B2
    优先权日:2019-05-09
    标 题:Compounds for use in synthesis of peptidomimetics
    发明人:AL-ABED YOUSEF; CHENG KAI FAN
    权利人:FEINSTEIN INSTITUTES FOR MEDICAL RESEARCH
    摘要:Synthesis of O-benzotriazole and O-imidazole synthons are described. Uses of synthons in synthesis of azapeptides and other peptidomimetics, azapeptides and other peptidomimetics synthesized from the synthons and uses of azapeptides and other peptidomimetics are also described.

    专利号:US-2023159450-A1
    优先权日:2020-05-08
    标 题 :Dimers for use in synthesis of peptidomimetics
    发明人:AL-ABED YOUSEF; ALTITI AHMAD
    权利人:FEINSTEIN INSTITUTES FOR MEDICAL RESEARCH
    摘要:Dimers for use in synthesis of peptidomimetics are described. Uses of dimers as synthons in synthesis of azapeptides and other peptidomimetics, azapeptides and other peptidomimetics synthesized from the dimers and uses of azapeptides and other peptidomimetics are also described.

    专利号:US-2020354404-A1
    优先权日:2019-05-09
    标 题 :Peptidomimetic agents, synthesis and uses thereof
    发明人:AL-ABED YOUSEF
    权利人:FEINSTEIN INSTITUTES FOR MEDICAL RESEARCH
    摘要:Compounds for use in synthesis of peptidomimetic agents; synthesis of peptidomimetic agents; peptidomimetic diagnostic and therapeutic agents; and uses of the compounds and peptidomimetic agents in drug discovery, diagnosis, prevention and treatment of diseases are described.

    专利号:WO-2025128985-A1
    优先权日:2023-12-14
    标题 :Sulfoxide and sulfone derivatives of thiocarbazates as synthons for azapeptides synthesis and process of using same
    发明人:AL-ABED YOUSEF
    权利人:FEINSTEIN INSTITUTES FOR MEDICAL RESEARCH
    摘要:Provided for herein are sulfoxide and sulfone derivatives of thiocarbazates that have the formula (I): wherein A, R, R 1 , R 2 , and n are defined herein. The compounds may be used as synthons in the synthesis of azaeptides and other aza- amino acid conjugates.

    专利号:US-2022243244-A1
    优先权日:2019-10-10
    标 题 :Compositions and methods for in vivo synthesis of unnatural polypeptides
    发明人:ROMESBERG FLOYD E; FISCHER EMIL C; HASHIMOTO KOJI; FELDMAN AARON W; DIEN VIVIAN T; ZHANG YORKE
    权利人:SCRIPPS RESEARCH INST
    摘要:Disclosed herein are compositions, methods, and kits for a cell incorporating unnatural amino acids into an unnatural polypeptide. Also disclosed herein are compositions, methods, and kits for increasing activity and yield of the unnatural polypeptide synthesized by the cell.

    供应商参考报价(招募中)

    品牌试剂参考报价(招募中)

    📌 第三方产品分析报告

    ✅ COA系统入驻 | 共享模式

    合成参考文献


    摘要:Joule, J. A., Science of Synthesis Knowledge Updates, (2010) 2, 108.
    参考文献:10.1038/nchembio.2285
    摘要:Elshahawi SI, Cao H, Shaaban KA, Ponomareva LV, Subramanian T, Farman ML, Spielmann HP, Phillips GN, Thorson JS, Singh S. Structure and specificity of a permissive bacterial C-prenyltransferase. Nature Chemical Biology. 2017 Feb 06;13(4):366–8. doi: 10.1038/nchembio.2285.
    📝 需求与反馈
    尽可能描述清楚需求与问题信息
    ×

    通知