CAS: 17093-74-2; Acetyl-L-Threonine

相似化合物

163277-80-3 2458-78-8 137197-06-9

上下游产品

CAS号72-19-5 L-苏氨酸 | CAS号108-24-7 乙酸酐

📜L-苏氨酸置于乙酸酐体系中,用 溶剂黄146 用作溶剂,化学反应 2.5H,反应生成乙酰基-L-苏氨酸
参考文献:Improved Synthesis Of D-Allothreonine Derivatives From L-Threonine
标题:Improved Synthesis Of D-Allothreonine Derivatives From L-Threonine
摘要:The Improved Synthesis Of Protected D-Allothreonine Derivatives [fmoc-D-Allothr(Bu-T)-Oh (1) And Fmoc-D-Allothr-(Obu)-Bu-T (2)] Is Described. The Epimerization Of Cheap L-Threonine (L-Thr) (3) With Catalytic Salicylaldehyde Afforded A Mixture Of L-Thr (3) And D-Allothr (4) And Separation Of Ammonium Salt Gave D-Allothr (4) In 96% De. The Chemoselective Deprotection Of Tert-Butyl Ether Or Tert-Butyl Ester Of Fmoc-D-Allothr(Bu-T)-(Obu)-Bu-T (5) Easily Succeeded In Converting Fmoc-D-Allothr(Bu-T)-Oh (1) Or Fmoc-D-Allothr-(Obu)-Bu-T (2),Respectively. (C) 2013 Elsevier Ltd. All Rights Reserved.
Doi:10.1016/j.Tet.2013.06.027

专利信息

专利号:US-10655153-B2
优先权日:2017-03-14
标 题 :Chemoenzymatic synthesis of peptide beta-lactones and beta-hydroxy acids
发明人：WENCEWICZ TIMOTHY A; SCHAFFER JASON E; RECK MARGARET R
权利人:WENCEWICZ TIMOTHY A; SCHAFFER JASON E; RECK MARGARET R; UNIV WASHINGTON
摘要:Methods of producing peptide beta-lactones and beta-hydroxy acids are disclosed that include contacting a beta-hydroxy-alpha-amino acid, an aryl carrier protein (ObiD), and ATP with a non-ribosomal protein synthetase. A continuous flow reactor is disclosed that includes an elongate conduit with at least one region that includes a first region with a non-ribosomal protein synthetase immobilized to a substrate. The non-ribosomal protein synthetase of the continuous flow reactor is configured to contact a flow of a reaction mixture that includes a beta-hydroxy-alpha-amino acid and an aryl carrier protein. The non-ribosomal protein synthetase is further configured to release a peptide beta-lactone into the flow of the reaction mixture.

专利号:US-2018265905-A1
优先权日:2017-03-14
标 题:Chemoenzymatic synthesis of peptide beta-lactones and beta-hydroxy acids

专利号:RU-2140988-C1
优先权日:1993-10-15
标 题:Method of synthesis of sugar 1,5-d-anhydrofructose (variants), antioxidant, sweetening agent

专利号:US-9567368-B2
优先权日:2013-11-29
标 题:Peptide tyrosinase activators
发明人：HANTASH BASIL M; UBEID ANAN ABU
权利人:ESCAPE THERAPEUTICS INC
摘要:Peptides that increase melanin synthesis are provided. These peptides include pentapeptides YSSWY (SEQ ID NO: 1), YRSRK (SEQ ID NO: 2), and their variants. The peptides may activate the enzymatic activity of tyrosinase to increase melanin synthesis. The pharmaceutical, cosmetic, and other compositions including the peptides are also provided. The methods of increasing melanin production in epidermis of a subject are provided where the methods include administering compositions comprising an amount of one or more peptides effective to increase the melanin production. The methods also include treating vitiligo or other hypopigmentation disorders with compositions including one or more peptides.

专利号:WO-2024032852-A1
优先权日:2022-08-12
标题 :Cycloacetamide, novel natural product from mortierella alpina, process for production thereof, use thereof and mortierella alpina dsm 34346
发明人：GRESSLER MARKUS; RASSBACH JOHANNES; MERSEBURGER PETER; ROHLFS MARKO; BINNEMANN NIKO
权利人:UNIV JENA FRIEDRICH SCHILLER; UNIV BREMEN
摘要:The invention relates to the natural product cycloacetamides A to F as novel metabolite from Mortierella alpina, to a process for production thereof, to the use thereof, and to the Mortierella alpina DSM 34346 strain. The object of the present invention, that of specifying a novel natural product (bioactive) from a group of basal evolutionary fungi that has barely been researched to date, such as Mortierella spec., by isolation and identification, which constitutes a novel pharmaceutical lead structure, of providing a biological method for economic and time-saving production thereof with high product yield and without any particular apparatus complexity and alternatively a chemical synthesis method for preparation thereof, and of explaining the use (bioactivity) thereof, is achieved in that cycloacetamides A to F are provided, which conform to the general formula cyclo-(-N-Ac-L-Thr-A-B-C-O-) where L-Thr denotes L-configured threonine, and in which A, B and C independently represent mutually identical or different L- or D-configured amino acids having nonpolar side chains, especially alanine (Ala), valine (Val), leucine (Leu), isoleucine (Ile), methionine (Met), phenylalanine (Phe), tyrosine (Tyr) or tryptophan (Trp), wherein the fungus Mortierella alpina is cultured in growth medium and this forms cycloacetamides A to F, which is extracted from the growth medium and separated in the form of a concentrated extract by preparative and semi-preparative HPLC into pure substances of cycloacetamides A to F, wherein cycloacetamides A to F act as insecticide and the producer strain is Mortierella alpina DSM 34346, and a chemical synthesis route is indicated as an alternative to the biological production of cycloacetamides A to F, wherein the cycloacetamides A to F are usable as insecticide.

专利号:US-2024209353-A1
优先权日:2021-04-08
标 题 :Nadk2 inhibition in cancer and fibrotic disorders
发明人：THOMPSON CRAIG B; SCHWOERER SIMON; ZHU JIAJUN
权利人:MEMORIAL SLOAN KETTERING CANCER CENTER; MEMORIAL HOSPITAL FOR CANCER AND ALLIED DISEASES; SLOAN KETTERING INST CANCER RES
摘要:Aspects of the disclosure provide methods for inhibiting cell proliferation and protein synthesis utilizing an antagonist of nicotinamide adenine dinucleotide kinase 2 (NADK2). In some aspects, these methods are used to treat a disease such as cancer or a disorder such as a fibrotic disorder. Further provided herein are compositions comprising a nutrient-deficient cell culture medium and an antagonist of NADK2.