CAS: 1660-04-4; 1-Acetyladamantane

相似化合物

2094-74-8 82094-52-8 78679-71-7

上下游产品

CAS号6600-42-6 1-(1-adamantyl)... | CAS号676-58-4 甲基氯化镁 | CAS号351464-84-1 N-Methoxy-N-met... | CAS号518050-70-9 2,5-dimethyl-2-... | CAS号518050-71-0 5-bromo-2,5-dim... | CAS号828-51-3 1-金刚烷甲酸 | CAS号917-54-4 甲基锂 | CAS号281-23-2 金刚烷 | CAS号431-03-8 2,3-丁二酮 | CAS号103-82-2 苯乙酸 | CAS号1298062-65-3 {2-[2-(1-adaman... | CAS号5122-82-7 1-金刚烷基溴甲酮 | CAS号39917-38-9 1-(3-羟基金刚烷-1-基)乙酮 | CAS号880-52-4 1-乙酰氨基金刚烷 | CAS号828-51-3 1-金刚烷甲酸 | CAS号2094-73-7 金刚烷-1-甲酸乙酯 | CAS号115749-26-3 1-(1'-chloroeth... | CAS号775-64-4 2-(1-金刚烷基)-2-丙醇

1-金刚烷甲酸置于三氯化铝,氯化亚砜,Copper(L) Chloride,Lithium Chloride体系中,用 四氢呋喃,甲苯 用作溶剂,化学反应 8.17H,反应生成1-金刚烷甲酮
参考文献:催化体系组成对含金刚烷酮形成的影响
标题:催化体系组成对含金刚烷酮形成的影响
摘要:描述了在催化量的金属卤化物存在下,通过酰氯与相应的格氏试剂的反应制备不对称酮.催化剂的组成对所需酮的收率以及副产物的形成有很大的影响.对于每个催化系统,酮的收率和副产物的数量随格氏试剂的添加时间而变化.我们在金刚烷-1-羰基氯与乙基溴化镁的模型反应中考察了这两个因素的影响,并从这一角度讨论了可能的机理.我们发现了zncl 2,Mncl 2,Alcl 3氯化铜作为活性催化组分,并开发了非常高效,廉价和快速的烷基金刚烷基酮的制备方法.还测试了该程序用于合成其他烷基芳基酮.
Doi:10.1016/j.Tet.2004.10.059

专利信息

专利号:US-2003180804-A1
优先权日:2001-10-29
标题:Solid phase synthesis of chemical libraries
发明人：PRYOR KENT E; LEWIS RONALD D; BROWN JASON W
权利人:CORVAS INT INC
摘要:The present invention provides compounds and compound libraries that are useful as protease modulators. The compounds and compound libraries are preferably made using the methods of the present invention which utilize peptide synthesis and combinatorial chemistry methods on a solid phase.

专利号:US-6358928-B1
优先权日:1999-11-22
标 题 :Peptidyl sulfonyl imidazolides as selective inhibitors of serine proteases
发明人：RASNICK DAVID W
权利人:ENZYME SYSTEMS PRODUCTS
摘要:Novel alpha-amino and peptidyl sulfonyl imidazolides, a method for their synthesis, and a method for inhibiting serine proteases therewith are disclosed. Pharmaceutical compositions containing alpha-amino and peptidyl sulfonyl imidazolides and their use in the treatment of disease states characterized by an over-activity of serine proteases are also disclosed. Novel synthetic methods for the synthesis of sulfonyl derivatives, particularly alpha-amino and peptidyl sulfonyl derivatives, from thioic acid S-esters are also disclosed.

专利号:US-2023037284-A9
优先权日:2018-11-30
标题:Combination therapy of peptidomimetic macrocycles
发明人：GUERLAVAIS VINCENT; ANNIS DAVID ALLEN
权利人:AILERON THERAPEUTICS INC
摘要:The present disclosure describes the synthesis of peptidomimetic macrocycles and methods of using peptidomimetic macrocycles to treat a condition. The present disclosure also describes methods of using peptidomimetic macrocycles in combination with at least one additional pharmaceutically-active agent for the treatment of a condition, for example, cancer.

专利号:RU-2118313-C1
优先权日:1997-05-06
标 题 :Method of synthesis of 1-(1-aminoethyl)-adamantane hydrochloride

专利号:WO-9918065-A1
优先权日:1997-10-03
标 题:Chiral amines
发明人：JOHNSON NICHOLAS BERNARD; BURK MARK JOSEPH; CASY GUY
权利人:CHIROTECH TECHNOLOGY LTD
摘要:An efficient synthesis of chiral amines (5) comprises preparing an enamide (4) from the oxime (2), and subjecting the enamide to catalytic asymmetric hydrogenation.

专利号:US-9150511-B2
优先权日:2011-05-24
标题 :Process for preparing saxagliptin and its novel intermediates useful in the synthesis thereof
发明人：KOVI RAVISHANKER; RAPOLE KESHAVRAO; NAIK ASHISH; KANNAPAN JAYARAMAN; MADALA MURALIKRISHNA; THAKOR SANJAY
权利人:APICORE US LLC
摘要:Methods of making saxagliptin, pharmaceutically acceptable salts and hydrates thereof and intermediates thereof.