CAS: 142374-19-4; Tert-Butyl 4-(2-Oxoethyl)Piperidine-1-Carboxylate

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135716-09-5 157688-46-5 89151-44-0

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CAS号89151-44-0 N-B°C-4-哌啶乙醇 | CAS号79-37-8 草酰氯 | CAS号135716-09-5 1-B°C-4-哌啶乙酸乙酯 | CAS号502609-58-7 tert-butyl 4-(2... | CAS号622-26-4 4-哌啶乙醇 | CAS号28356-58-3 4-吡啶乙酸 | CAS号135716-08-4 2-(1-B°C-4-亚哌啶基)乙酸乙酯 | CAS号24424-99-5 二碳酸二叔丁酯 | CAS号6622-91-9 4-吡啶乙酸盐酸盐 | CAS号157688-46-5 1-叔丁氧羰基-4-哌啶乙酸 | CAS号142355-80-4 1-B°C-4-(4-甲氧基-... | CAS号301221-63-6 4-(1-溴-2-氧代乙基)哌... | CAS号896103-62-1 4-(2-(甲基氨基)乙基)哌... | CAS号890849-78-2 1-N-B°C-4-(3-cb... | CAS号158469-71-7 tert-butyl 4-(3... | CAS号142355-81-5 1-B°C-4-(4-溴丁基)-哌啶 | CAS号142355-83-7 4-(1-B°C-4-哌啶基)-1-丁醇 | CAS号142247-38-9 N-B°C-4-哌啶丁酸 | CAS号256411-39-9 1-B°C-4-(氰基甲基)哌啶 | CAS号301185-41-1 4-(丙-2-炔-1-基)哌啶...

4-哌啶乙酸置于sodium Hydroxide,硼烷四氢呋喃络合物,三氧化硫吡啶,二甲基亚砜,三乙胺体系中,用 1,4-二氧六环 用作溶剂,化学反应生成4-(2-氧代乙基)哌啶-1-羧酸叔丁酯
参考文献:使用noyori催化剂不对称氢化3-亚烷基-2-哌啶酮.N-取代基对对映选择性的影响
标题:使用noyori催化剂不对称氢化3-亚烷基-2-哌啶酮.N-取代基对对映选择性的影响
摘要:发现由binap-Ru(II)配合物催化的3-亚烷基-2-哌啶酮不对称氢化中的对映选择性受内酰胺氮上的内部取代基的影响很大,在52中得到相应的3-烷基-2-哌啶酮-92%ee.
Doi:10.1016/0040-4039(95)01546-9

专利信息

专利号:US-12441733-B2
优先权日:2018-03-26
标题:Substituted 2,4-dioxotetrahydropyrimidines as intermediates in the synthesis of bruton's tyrosine kinase inhibitors
发明人：ARISTA LUCA; HEBACH CHRISTINA; HOLLINGWORTH GREGORY JOHN; HOLZER PHILIPP; IMBACH-WEESE PATRICIA; LORBER JULIEN; MACHAUER RAINER; SCHMIEDEBERG NIKO; VULPETTI ANNA; ZOLLER THOMAS
权利人:NOVARTIS AG
摘要:The invention relates to compounds of the formulae (I), (III), (IIIa), (XXIa), (XXIII), and/or (XLVI)or a pharmaceutically acceptable salt thereof, wherein the substituents are as defined in the specification; to intermediates in the preparation of the compounds, to pharmaceutical compositions comprising the compounds and to use of the compounds in the treatment of disease.

专利号:WO-2025026392-A1
优先权日:2023-08-02
标题 :Kinesin kif18a inhibitor and use thereof
发明人：XIAO YISONG; LAI KUNMIN; GU XIAOHUI; WANG MINGHUA; DENG JIACHEN; HU MIN
权利人:SHANGHAI APEIRON THERAPEUTICS COMPANY LTD
摘要:A KIF18 inhibitor having a structure as shown in formula (I) and a synthesis method therefor. The compound can be used to adjust the KIF18A protein, thereby affecting a cell cycle and cell proliferation process for the treatment of cancer and cancer-related diseases. Further disclosed are a pharmaceutical composition containing the compound, and a method for the treatment of conditions associated with KIF18A activity.

专利号:WO-2025067239-A1
优先权日:2023-09-26
标 题 :Kinesin kif18a inhibitor, and application thereof
发明人：XIAO YISONG; GU XIAOHUI; LAI KUNMIN; WANG MINGHUA; HU MIN
权利人:SHANGHAI APEIRON THERAPEUTICS COMPANY LTD
摘要:A KIF18 inhibitor, and a synthesis method therefor, capable of adjusting a KIF18A protein, so as to affect cell cycle and cell proliferation processes, in order to treat cancers and cancer-related diseases. Also provided are a pharmaceutical composition including the KIF18 inhibitor compound, and a method for treating KIF18A activity-related conditions.