CAS: 137071-78-4; 3,6-Dichlorotrimellitic Acid

相似化合物

27563-65-1 16110-99-9 25641-98-9

2,5-二氯对二甲苯置于aluminum (III) Chloride,Potassium Permanganate,Potassium Carbonate体系中,用 水,1,2-二氯乙烷 用作溶剂,化学反应 5.5H,反应生成3,6-二氯苯-1,2,4-三羧酸
参考文献:Improved Synthetic Procedures For 4,7,2',7'-Tetrachloro-And 4',5'-Dichloro-2',7'-Dimethoxy-5(And 6)-Carboxyfluoresceins
标题:Improved Synthetic Procedures For 4,7,2',7'-Tetrachloro-And 4',5'-Dichloro-2',7'-Dimethoxy-5(And 6)-Carboxyfluoresceins
摘要:Literature Syntheses Of 4,7,2',7'-Tetrachloro-5(And 6)-Carboxyfluorescein ("5 And 6 Tet") 1 And 4',5' Dichloro-2',7'-Dimethoxy-5(And 6) Carboxyfluorescein ("5 And 6 Joe") 2 Are Reviewed,And New,Preparatively Useful Methods Are Presented. A Three-Step Synthesis Of 1 Was Developed,Which Proved To Be More Efficient Than The Published Seven Step Synthesis Of This Compound. The Published Synthesis Of 2 Also Proved Difficult To Reproduce,And A Better Workup Of The Key Intermediate 2-Chloro-4-Methoxy Resorcinol Was Devised. Isolation Of Purified Single Isomers Of Both Dyes Is Described.
Doi:10.1021/op000292O

专利信息

专利号:US-7179906-B2
优先权日:1996-04-01
标 题 :Asymmetric benzoxanthene dyes
发明人：BENSON SCOTT C; MENCHEN STEVEN M; THEISEN PETER D; HENNESSEY KEVIN M; FURNISS VERGINE C; HAUSER JOAN D
权利人:APPLERA CORP
摘要:A class of asymmetric monobenzoxanthene compounds useful as fluorescent dyes are disclosed having the structure n nwherein Y 1 and Y 2 are individually hydroxyl, amino, imminium, or oxygen, R 1 –R 8 are hydrogen, fluorine, chlorine, alkyl, alkene, alkyne, sulfonate, amino, amido, nitrile, alkoxy, linking group, and combinations thereof, and R 9 is acetylene, alkane, alkene, cyano, substituted phenyl, and combinations thereof. The invention further includes novel intermediate compounds useful for the synthesis of asymmetric benzoxanthene compounds having the general structuren n nwhere substituents R 3 –R 7 correspond to like-referenced substituents in the structure of described above, and Y 2 is hydroxyl or amine. In another aspect, the invention includes methods for synthesizing the above dye compounds and intermediates. In yet another aspect, the present invention includes reagents labeled with the asymmetric benzoxanthene dye compounds, including deoxynucleotides, dideoxynucleotides, phosphoramidites, and polynucleotides. In an additional aspect, the invention includes methods utilizing such dye compounds and reagents including dideoxy polynucleotide sequencing and fragment analysis methods.

专利号:CN-116606271-B
优先权日:2023-07-21
标 题 :Synthesis method of 3, 6-dichloro trimellitic anhydride