专利号:US-11753440-B2 优先权日:2018-06-05 标题 :Methods for the synthesis of arginine-containing peptides 发明人:HEIDL MARC; GEOTTI-BIANCHINI PIERO 权利人:DSM IP ASSETS BV 摘要:Methods for the synthesis of arginine-containing peptides are provided. The methods include a deprotection step that minimizes the transfer of by-products deriving from cleaved sulfonyl-5 based side chain protecting groups from arginine to amino acids carrying electron rich side chains.
专利号:US-4764263-A 优先权日:1987-05-18 标 题:Electrochemical synthesis of substituted aromatic amines in basic media 发明人:GREGORY THOMAS D; STUTTS KENNETH J 权利人:DOW CHEMICAL CO 摘要:Substituted amino aromatic compounds such as 3-amino-4-hydroxybenzoic acid are prepared by electrolytically reducing the corresponding nitro aromatic compound in a basic medium at temperatures below 60° C. and current densities greater than 50 milliamps per square centimeter. The aminohydroxybenzoic acids are useful in the preparation of polybenzoxazoles which are used to make fibers and composites having high strength and thermal stability.
专利号:US-3573253-A 优先权日:1968-11-18 标题:Preparation of cross-linked poly (4-hydroxy - 3 - nitro) (nonsubstituted or alpha and/or beta substituted) stryene 发明人:GRAY DON N 权利人:DON N GRAY 摘要:THERE IS DISCLOSED A PROCESS FOR PREPARING A SOLID PHASE, POLYMERIC SUBSTRATE COMPRISING A CROSS-LINKED POLY (4HYDROXY-3-NITRO) STYRENE WHICH IS ESPECIALLY SUITABLE FOR THE SYNTHESIS OF POLYPEPTIDES. THE POLYSTYRENE MAY BE NONSUBSTITUTED OR SUBSTITUTED (ALPHA AND/OR BETA).
专利号:US-8067460-B2 优先权日:2004-10-04 标 题 :5-phenoxyalkoxypsoralens and methods for selective inhibition of the voltage gated Kv1.3 potassium channel 发明人:WULFF HEIKE; SANKARANARAYANAN ANANTHAKRISHNAN; HAENSEL WOLFRAM; SCHMITZ ALEXANDER; SCHMIDT-LASSEN KRISTINA 权利人:WULFF HEIKE; SANKARANARAYANAN ANANTHAKRISHNAN; HAENSEL WOLFRAM; SCHMITZ ALEXANDER; SCHMIDT-LASSEN KRISTINA; UNIV CALIFONIA 摘要:Compositions of matter comprising 5-phenoxyalkoxypsoralen compounds and their method of synthesis and use. The compounds are useable to treat diseases or disorders in human or animal subjects, including autoimmune diseases. The compounds inhibit potassium channels, including the Kv1.3 channel and at least some of the therapeutic effects of such compounds may be due at least in part to potassium channel inhibition. In some embodiments, the compounds are more selective for certain potassium channels (e.g., Kv1.3 channels) than other potassium channels (e.g., Kv1.5 channels).
专利号:WO-2019234108-A1 优先权日:2018-06-05 标 题 :Methods for the synthesis of arginine-containing peptides
专利号:US-2021230220-A1 优先权日:2018-06-05 标 题 :Methods for the synthesis of arginine-containing peptides
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