专利号:US-2016214860-A1 优先权日:2013-09-19 标题:Method of synthesis of unsolvated mixed cation borohydrides 发明人:JARON TOMASZ; WEGNER WOJCIECH; GROCHALA WOJCIECH 权利人:JAROÑ Tomasz; WEGNER WOJCIECH; GROCHALA WOJCIECH 摘要:The present invention relates to a novel method of synthesis of unsolvated mixed cation borohydrides of a general formula M x M′ y (BH 4 ) z , where M and M′ stand for metal cations, x, y, and z are stoichiometric coefficients. The method of synthesis according to the present invention is characterised in that the precursors having a general formula M[A n ] u and [Cat] v M′(BH 4 ) w are used for the synthesis, where [An] stands for a weakly coordinating anion; [Cat] stands for weakly coordinating cation; u, v, and w are the stoichiometric coefficients; and the synthesis is carried out under an inert to the reagents atmosphere—according to the general reaction equation: x M[An] u +y [Cat] v M′(BH 4 ) w →M x M′ y (BH 4 ) z +xu [Cat][An] where z=yw, xu=yv; M x M′ y (BH 4 ) z is the product of the reaction.
专利号:US-9353057-B2 优先权日:2003-12-30 标 题:Synthesis of acyloxyalkyl carbamate prodrugs and intermediates thereof 发明人:GALLOP MARK A; DAI XUEDONG; SCHEUERMAN RANDALL A; RAILLARD STEPHEN P; MANTHATI SURESH K; YAO FENMEI; PHAN THU; LUDWIKOW MARIA; PENG GE; BHAT SEEMA 权利人:XENOPORT INC 摘要:Methods for synthesis of 1-(acyloxy)-alkyl carbamates, particularly, the synthesis of 1-(acyloxy)-alkyl carbamate prodrugs of primary or secondary amine-containing drugs are described. Also described are methods for synthesis of 1-(acyloxy)-alkyl N-hydroxysuccinimidyl carbonates which are useful intermediates in the synthesis of 1-(acyloxy)-alkyl carbamates are also described.
专利号:US-7241399-B2 优先权日:2000-09-08 标题 :Synthesis of nanoparticles 发明人:HAUBOLD STEPHAN; HAASE MARKUS; RIWOTZKI KARSTEN; WELLER HORST; MEYSSAMY HEIKE; IBARRA FERNANDO 权利人:CT ANGEWANDTE NANOTECH CAN 摘要:Methods for the preparation of inorganic nanoparticles capable of fluorescence, wherein the nanoparticles consist of a host material that comprises at least one dopant. The synthesis of the invention in organic solvents allows to gain a considerably higher yield compared to the prior art synthesis in water. All kinds of objects can advantageously be marked and reliably authenticated by using an automated method on the basis of a characteristic emission. Further, the size distribution of the prepared nanoparticles is nartower which renders a subsequent size-selected separation process superfluous.
专利号:US-7199257-B1 优先权日:1999-06-10 标题 :Process for the synthesis of N-(4-cyano-3-trifluoromethylphenyl)-3-(4-fluorophenylsulfonyl)-2-hydroxy-2-methylpropionamide 发明人:SOEROES BELA; TUBA ZOLTAN; GALIK GYOERGY; BOR ADAM; DEMETER ADAM; TRISCHLER FERENC; HORVATH JANOS; BRLIK JANOS 权利人:RICHTER GEDEON VEGYESZET 摘要:A new process is disclosed for the synthesis of racemic or optically pure N-[4-cyano-3-trifluoro-methyl-phenyl]-3[4-fluorophenyl-sulfonyl]-2-hydroxy-2-methylpropionamide. The process includes the formation of several novel intermediates in the synthesis.
专利号:US-6540970-B1 优先权日:1999-11-18 标题:Method for the synthesis of molecular sieves 发明人:STROHMAIER KARL G; VAUGHAN DAVID E W 权利人:EXXON MOBIL CHEM PATENTS INC 摘要:The present invention provides a method for the synthesis of MeAPO molecular sieves which includes the following steps: providing a source of alumina, a source of phosphorus, water, and a template suitable for forming a MeAPO molecular sieve; providing a source of metal (Me) including metal particles, the metal particles measuring, in their largest dimension, equal to or less than five nanometers; providing a water soluble organic solvent capable of solubilizing the source of metal; forming a synthesis mixture from the source of alumina, the source of phosphorus, the water, the template, the source of metal, and the solvent; and forming a MeAPO molecular sieve from the synthesis mixture.
专利号:WO-2010078250-A1 优先权日:2008-12-30 标 题:Synthesis of (2-amino)-tetrahydrocarbazole-propanoic acid 发明人:WEI YUAN; Li tianqiao; CHI YONGXIANG; ZHU JINGYANG 权利人:CHIRAL QUEST INC; WEI YUAN; Li tianqiao; CHI YONGXIANG; ZHU JINGYANG 摘要:The present invention provides a new approach to the synthesis of 2-amino-tetrahydrocarbazole-propanoic acid, a key intermediate for the synthesis of Ramatroban. More specifically, a synthesis of 2-amino-tetrahydrocarbazole- propanoic acid which includes oxidizing an aminocyclohexanol to form an aminocyclohexanone, condensing the aminocyclohexanone to form a tetrahydrocarbazole, deprotecting the tetrahydrocarbazole to yield a racemic mixture of a tetrahydrocarbazole, resolving the racemic mixture to obtain a yield mixture with an enantiomeric excess of one enantiomer over another, alkylating the excess enantiomer to yield an alkyl ester, and hydrolyzing the alkyl ester to yield 2-amino-tetrahydrocarbazole-propanoic acid.
参考文献:10.1002/rcm.4423 摘要:Brewer TM, Szakal C, Gillen G. Method for improved secondary ion yields in cluster secondary ion mass spectrometry. Rapid Commun Mass Spectrom. 2010 Mar 15;24(5):593–8. doi: 10.1002/rcm.4423. 参考文献:10.1021/la202143t 摘要:Lee S, Park S, Lee Y, Lee J, Lee H, Seo Y. Guest gas enclathration in semiclathrates of tetra-n-butylammonium bromide: stability condition and spectroscopic analysis. Langmuir. 2011 Sep 06;27(17):10597–603. doi: 10.1021/la202143t. 参考文献:10.1107/s1600536811009792 摘要:Lozano-Rodriguez MJ, Thuéry P, Petit S, Copping R, Mustre de Leon J, Den Auwer C. Tris(tetrabutylammonium) tris(nitrato-κ2O,O′)tetrakis(thiocyanato-κN)thorium(IV). Acta Crystallogr E Struct Rep Online. 2011 Mar 26;67(4):m487. doi: 10.1107/s1600536811009792. 参考文献:10.1107/s1600536811008099 摘要:Heidelberg T, Hussen RSD, Rodzi NZM, Ng SW, Tiekink ERT. 4-Formylphenyl 2,3,4,6-tetra-O-acetyl-β-D-glucopyranoside. Acta Crystallogr E Struct Rep Online. 2011 Mar 09;67(4):o825. doi: 10.1107/s1600536811008099. 参考文献:10.1107/s1600536811008257 摘要:Hussen RSD, Heidelberg T, Rodzi NZM, Ng SW, Tiekink ERT. 4-Formylphenyl 2,3,4,6-tetra-O-acetyl-β-D-galactopyranoside. Acta Crystallogr E Struct Rep Online. 2011 Mar 09;67(4):o826. doi: 10.1107/s1600536811008257.