CAS: 103816-16-6; (S)-4-Ethyl-4-Hydroxy-3,14-Dioxo-3,4,12,14-Tetrahydro-1H-Pyrano[3',4':6,7]Indolizino[1,2-B]Quinolin-9-Yl [1,4'-Bipiperidine]-1'-Carboxylate
- 英文名称(S)-4-Ethyl-4-Hydroxy-3,14-Dioxo-3,4,12,14-Tetrahydro-1H-Pyrano[3',4':6,7]Indolizino[1,2-B]Quinolin-9-Yl [1,4'-Bipiperidine]-1'-Carboxylate
- 中文名称10-[4-(1-哌啶基)-1-哌啶基羰基氧基]喜树碱
- IUPAC名称(S)-4-ethyl-4-hydroxy-3,14-dioxo-3,4,12,14-tetrahydro-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinolin-9-yl [1,4'-bipiperidine]-1'-carboxylate
- 其它别名11-Desethyl Irinotecan; Irinotecan Impurity A; 10-[4-(1-Piperidino)-1-Piperidinocarbonyloxy]Camptothecin; Irinotecan Ep Impurity A; Irinotecan Impurity 11; Irinotecan Hydrochloride Impurity A; (S)-4-Ethyl-4-Hydroxy-3; 7-Desethyl Irinotecan
- CAS编号103816-16-6
- MFCD编号:MFCD28138354
- FDA UNII编号:JHM7B5DOV5
- 分子式:C31H34N4O6分子量:558.64
- 产品CID: 73458
- 产品分类分析化学 → 标准品 → 药典标准品和杂质标准品
物理性质
MSDS等安全信息
上下游产品
4-nitrophenyl camptothecin-10-yl carbonate 4-piperidinopiperidin (S)-10-hydroxycamptothecin 4-piperidinopiperidine-1-carbonyl chloride hydr°Chloride irinotecan合成工艺路线路线简述
📜10-羟基喜树碱置于三乙胺体系中,化学反应 3.0H,反应生成10-[4-(1-哌啶基)-1-哌啶基羰基氧基]喜树碱
参考文献:Synthesis And Evaluation Of A Dha And 10-Hydroxycamptothecin Conjugate
标题:Synthesis And Evaluation Of A Dha And 10-Hydroxycamptothecin Conjugate
摘要:We Have Synthesized A Conjugate Of Cis-4,7,10,13,16,19-Docosahexenoic Acid (Dha) And 10-Hydroxycamptothecin (Hcpt),Dha-Hcpt. The Antitumor Activity Of Dha-Hcpt Was Evaluated In Vitro Against L1210 Leukemia Cells And In Experimental Animal Tumor Models Including L1210 Leukemia,Lewis Lung Carcinoma,And Colon 38 Adenocarcinoma. Dha-Hcpt Showed A Greatly Improved Antitumor Efficacy Compared To Hcpt. (C) 2005 Elsevier Ltd. All Rights Reserved.
Doi:10.1016/j.Bmc.2005.06.039
海关参考信息
- 2905122000-异丙醇
2905310000-1,2-乙二醇
2905320000-1,2-丙二醇
2905142000-仲丁醇
2905499000-其他多元醇 - 💡 提示：海关信息按照顺序优先匹配，如需确认的海关信息，请参考相关资料。
- 详情请参考：📖 海关编码查询和海关进出口税则
专利信息
专利号:US-9765083-B2
优先权日:2013-12-03
标 题 :Method for the synthesis of irinotecan
发明人：ZABUDKIN ALEXANDER; MATVIENKO VIKTOR
权利人:SYNBIAS PHARMA AG
摘要:The present invention relates to a method for the synthesis of 7-ethyl-10-[4-(1-piperidino)-1-piperidino]carbonyloxycamptothecin (i.e. iriniotecan), comprising: (a) preparing 10-[4-(1-piperidino)-1-piperidino]carbonyloxycamptotecin; and (b) selectively ethylating the compound of step (a) at the 7-position, thus resulting in the preparation of 7-ethyl-10-[4-(1-piperidino)-1-piperidino]carbonyloxycamptothecin. The present invention is further directed to the use of 10-[4-(1-piperidino)-1-piperidino]carbonyloxycamptothecin (i.e. 7-des-ethyl-irinotecan) as intermediate in a method for the synthesis of irinotecan as described.
专利号:US-2012295866-A1
优先权日:2011-04-13
标题:Synthesis And Use Of Glycoside Pro-Drug Analogs
发明人：SHULL BRIAN; BALDWIN JOHN; GOPALASWAMY RAMESH; HAROON ZISHAN
权利人:SHULL BRIAN; BALDWIN JOHN; GOPALASWAMY RAMESH; HAROON ZISHAN; NUTEK PHARMA LTD
摘要:The present invention relates to methods and compositions for the synthesis, production, and use of pro-drug analogs. This invention relates to a method for the production of a broad group of glycosylated drugs, including but not limited to propofol, acetaminophen, and camptothecin carbohydrate derivatives.
专利号:EP-3030567-A1
优先权日:2013-12-03
标题 :Method for the synthesis of irinotecan
专利号:EP-3030567-B1
优先权日:2013-12-03
标题 :Method for the synthesis of irinotecan
专利号:CA-2924256-C
优先权日:2013-12-03
标 题:Method for the synthesis of irinotecan
专利号:US-2016264590-A1
优先权日:2013-12-03
标题 :Method for the synthesis of irinotecan
