CAS: 942487-16-3; N-(2-((1S,4R)-6-((4-(Cyclobutylamino)-5-(Trifluoromethyl)Pyrimidin-2-yl)Amino)-1,2,3,4-Tetrahydro-1,4-Epiminonaphthalen-9-yl)-2-Oxoethyl)Acetamide

📜N-[2-[4-[[4-Chloro-5-(Trifluoromethyl)Pyrimidin-2-Yl]Amino]-11-Azatricyclo[6.2.1.02,7]Undeca-2(7),3,5-Trien-11-Yl]-2-Oxoethyl]Acetamide,环丁基胺置于环丁基胺体系中,用62的收率获得产物n-[2-[(1S,4R)-6-[[4-(环丁基氨基)-5-(三氟甲基)-2-嘧啶基]氨基]-1,2,3,4-四氢萘-1,4-亚氨-9-基]-2-氧代乙基]乙酰胺
参考文献:Pyrimidine Derivatives For The Treatment Of Abnormal Cell Growth
标题:Pyrimidine Derivatives For The Treatment Of Abnormal Cell Growth
摘要:本发明涉及式1的化合物或其药学上可接受的盐,其中ar是式的基团,而r1,R2,R13,A,K,M,L1,L2,X,Y1,Y2,Q,其盐,R1,R2,R13,A,K,L1,L2,W,X,Z1,Z2,Y1,Y2,Z1,Z2,M,Q,W,X,M,P和q的定义如本文所述.这些新型嘧啶衍生物在哺乳动物中治疗异常细胞增长,如癌症中有用.本发明还涉及使用这些化合物治疗哺乳动物,特别是人类中的异常细胞增长的方法,以及含有这些化合物的药物组合物.

专利信息

专利号:US-11285169-B2
优先权日:2013-03-13
标题 :Methods for modulating chemotherapeutic cytotoxicity
发明人：ROBERTS DAVID D; SOTO PANTOJA DAVID R
权利人:US HEALTH
摘要:Methods of reducing cytotoxicity of a chemotherapeutic agent to non-cancer cells by administering to a subject with cancer an effective amount of an agent that inhibits CD47 signaling and a DNA damaging agent, such as an anthracycline, topoisomerase inhibitor, or nucleotide synthesis inhibitor, are provided. Example disclosed methods reduce cardiotoxicity. In one example, the methods include administering to a subject with cancer an effective amount of a CD47 antisense morpholino oligonucleotide and an anthracycline such as doxorubicin. Methods of increasing cytotoxicity of a chemotherapeutic agent in cancer cells by administering to a subject with a tumor an effective amount of an agent that inhibits CD47 signaling and a DNA damaging agent such as an anthracycline, topoisomerase inhibitor, or nucleotide synthesis inhibitor, are also provided. In some embodiments, the inhibitor of CD47 signaling is administered to the subject before, during, or after the administration of the DNA damaging agent.

专利号:US-2012009151-A1
优先权日:2007-12-21
标题 :Triazines And Related Compounds Having Antiviral Activity, Compositions And Methods Thereof
发明人：HAN AMY QI; COBURN GLEN A; PROVONCHA KATHLEEN P; ROTSHTEYN YAKOV
权利人:HAN AMY QI; COBURN GLEN A; PROVONCHA KATHLEEN P; ROTSHTEYN YAKOV; PROGENICS PHARM INC
摘要:Disclosed herein are novel triazines and related compounds, the synthesis thereof, and compositions, including pharmaceutical compositions, comprising the novel triazines and related compounds. Such novel triazines and related compounds function to inhibit or block entry of viruses of the Flaviviridae family, including Hepatitis C virus (HCV), into cells that are susceptible to virus infection. These compounds are useful for the treatment, therapy and/or prophylaxis of viral diseases and infection, including HCV infection.