CAS: 935-28-4; 2,6-Diethylpyridine

该化合物是替代的衍生物,其特点是在环的2和6个位置上存在乙基组,这种结构改变加强了其消毒和电子特性,使其成为有机合成和催化的宝贵中间体.该化合物与非替代的相比,其基本性和选择性有所改善,促进了其在协调化学和过渡性金属综合体中的使用.它界定了在各种反应条件下的对称性和稳定性,使之适合用于制药和农用化学研究.高纯度和一贯质量的2,6-二乙基确保了在高要求的合成工艺中的可靠性能.

结构式图片

相似化合物

877133-54-5 1122-69-6 74701-47-6

物理性质

MSDS等安全信息

上下游产品

CAS号1129-30-2 2,6-二乙酰基吡啶 | CAS号2402-78-0 2,6-二氯吡啶 | CAS号925-90-6 乙基溴化镁 | CAS号108-48-5 2,6-二甲基吡啶 | CAS号74-88-4 碘甲烷 | CAS号143329-89-9 1-(6-(1-羟基-乙基)-... | CAS号114960-28-0 2,6-diethyl-pyr... | CAS号77-78-1 硫酸二甲酯 | CAS号6832-21-9 2,6-二-异丙基吡啶 | CAS号85048-76-6 2,6-diethylpyri...

合成工艺路线路线简述

  • 100-71-0 = 935-28-4
    反应条件:1.1 Catalysts: Tris(Pentafluorophenyl)Borane,Stereoisomer Of Bis[[2-(Dimethylamino-Kn)Phenyl]Methyl-Kc][(1,2,3,4,5-η)-1,2,3,4... Solvents: Toluene; 8 H,3 Atm,70 °C
    标题:Rare-Earth Catalyzed C-H Bond Activation And Alkylation Of Pyridines
    作者:Guan,Bingtao; Hou,Zhaomin
    参考文献:Kidorui 日期:2012 卷标:60 页码:156-157]

    2402-78-0 + 925-90-6 = 935-28-4
    反应条件:1.1 Catalysts: Dichloro[1,1′-(1,3-Propanediyl)Bis[1,1-Diphenylphosphine-Kp]]Nickel Solvents: Diethyl Ether
    标题:Synthetic Route Optimization Of Pf-00868554,An Hcv Polymerase Inhibitor In Clinical Evaluation
    作者:Johnson,Sarah; Drowns,Matt; Tatlock,John; Linton,Angelica; Gonzalez,Javier; Et Al
    参考文献:Synlett 日期:2010 卷标:(5) 页码:796-800]

    2402-78-0 + 925-90-6 = 935-28-4
    反应条件:1.1 Catalysts: Dichloro[1,1′-(1,3-Propanediyl)Bis[1,1-Diphenylphosphine-Kp]]Nickel Solvents: Diethyl Ether; 0 °C; Overnight,Rt; 3 H,Rt -> Reflux
    标题:Preparation Of 4-Hydroxy-3-Heterocyclylalkyl-5,6-Dihydro-2H-Pyran-2-Ones As Inhibitors Of Hepatitis C Virus Rna-Dependent Rna Polymerase,And Compositions And Treatments Using The Same
    参考文献:World Intellectual Property Organization]

    = 935-28-4 [标题:Reaction Conditions
    标题:Arenes Disubstituted With Primary Alkyl Groups From Xylylene Dianions
    作者:Bates,Robert B.; Ogle,Craig A.
    参考文献:Journal Of Organic Chemistry 日期:1982 卷标:47(20) 页码:3949-52]

    = 935-28-4 [标题:Reaction Conditions
    标题:Catalytic Reactions Of Pyridines. 2. Direct Vapor-Phase Alkylation Of Pyridines With Alcohols Over Nickel-Substituted Zeolites
    作者:Kashiwagi,Hiroshi; Enomoto,Saburo
    参考文献:Nippon Kagaku Kaishi 日期:1980 卷标:(4) 页码:551-6]

    = 935-28-4 [标题:Reaction Conditions
    标题:Polyacylation Of Propene Derivatives: Allyltrimethylsilane As Precursor
    作者:Roussel,Christian; Popescu,Cristina
    参考文献:Revue Roumaine De Chimie 日期:1993 卷标:38(4) 页码:425-37]

    1129-30-2 = 935-28-4
    反应条件:1.1 Reagents: Hydrazine Solvents: Diethylene Glycol; 30 Min,170 °C; 170 °C -> Rt1.2 Reagents: Potassium Hydroxide; 2 H,200 °C; 200 °C -> Rt1.3 Reagents: Water; Rt
    标题:A Preparation Of Piperidine Derivatives,Useful As Glycine Transporter 1 Inhibitors
    参考文献:World Intellectual Property Organization]

    1129-30-2 = 935-28-4
    反应条件:1.1 Reagents: Hydrazine Hydrate (1:1) Solvents: Diethylene Glycol; 30 Min,170 °C; 170 °C -> Rt1.2 Reagents: Potassium Hydroxide; 2 H,200 °C
    标题:Preparation Of Glyt1 Transporter Inhibitors And Their Use In Treatment Of Neurological And Neuropsychiatric Disorders
    参考文献:World Intellectual Property Organization]

    2402-78-0 + 925-90-6 = 935-28-4
    反应条件:1.1 Catalysts: Dichloro[1,1′-(1,3-Propanediyl)Bis[1,1-Diphenylphosphine-Kp]]Nickel Solvents: Diethyl Ether; 0 °C; 0 °C -> Rt; Overnight,Reflux1.2 Reagents: Ammonium Chloride Solvents: Water; 0 °C
    标题:Attenuation Of London Dispersion In Dichloromethane Solutions
    作者:Pollice,Robert; Bot,Marek; Kobylianskii,Ilia J.; Shenderovich,Ilya; Chen,Peter
    参考文献:Journal Of The American Chemical Society 日期:2017 卷标:139(37) 页码:13126-13140]

    143329-89-9 = 935-28-4
    反应条件:1.1 Reagents: Zinc Solvents: Formic Acid
    标题:Synthesis Of Some 2,6-Di- And 1,2,6-Trisubstituted-1,4-Dihydropyridines As Antimicrobial Agents
    作者:Attia,A.; El-Salam,O. I. Abd; Amr,A.
    参考文献:Egyptian Journal Of Chemistry 日期:2000 卷标:43(4) 页码:297-307]

    1122-69-6 = 935-28-4
    反应条件:1.1 Reagents: Butyllithium,Triethylamine Solvents: Tetrahydrofuran,Hexane; Rt -> -40 °C; -40 °C; 1 H,-40 °C; -40 °C -> 0 °C1.2 0 °C; > 0 °C; 1 H,> 0 °C
    标题:Polymerization Initiator,Modified Conjugated Diene Polymer And Tire Produced Therefrom
    参考文献:European Patent Organization]

    114960-28-0 = 935-28-4
    反应条件:1.1 Reagents: Water Solvents: Methanol,Water
    标题:Synthesis And Photoisomerization Of Sterically Hindered 2,6-Dialkylpyridine N-Oxides
    作者:Weber,Horst; Rohn,Thomas
    参考文献:Zeitschrift Fuer Naturforschung 日期:1990 卷标:45(5) 页码:701-6]

    = 935-28-4 [标题:Reaction Conditions
    标题:Sterically Hindered Pyridinium Salts. Part I. Base-Catalyzed Carbon-Alkylation Of 2,6-Lutidine Methiodide
    作者:Weber,Horst; Pant,Johannes
    参考文献:Archiv Der Pharmazie (Weinheim 日期:1980 卷标:313(4) 页码:307-10]

    = 935-28-4 [标题:Reaction Conditions
    标题:Alkylpyridines
    参考文献:Japan]

    = 935-28-4 [标题:Reaction Conditions
    标题:General Synthesis Of 2,6-Dialkylpyridines
    作者:Francis,Robert F.; Wisener,J. T.; Paul,James M.
    参考文献:Journal Of The Chemical Society [section] D: Chemical Communications 日期:1971 卷标:(22)
📜1-(6-(1-羟基-乙基)-吡啶-2-基)-乙醇置于甲酸,锌体系中,化学反应 24.0H,以64%的收率获得产物2,6-二乙基吡啶
参考文献:Attia,A.; El-Salam,O. I. Abd; Amr,A.,Egyptian Journal Of Chemistry,2000,Vol. 43,# 4,P. 297-308
标题:Attia,A.; El-Salam,O. I. Abd; Amr,A.,Egyptian Journal Of Chemistry,2000,Vol. 43,# 4,P. 297-308

海关参考信息

专利信息


专利号:US-2002147331-A1
优先权日:2001-02-02
标题:Methods for synthesis of oligonucleotides
发明人：GUZAEV ANDREI P; MANOHARAN MUTHIAH
摘要:The present invention is directed to improved methods and compositions for synthesis of oligonucleotides and other phosphorus-linked oligomers, without the need for phosphoryl protecting groups. The methods involve the reaction of nucleoside phosphoramidites with a support-bound oligomer having one or more unprotected phosphorus-containing internucleoside linkages in the presence of a neutralizing agent.

专利号:US-6495695-B2
优先权日:2001-03-30
标题:Process for the preparation of a collidine and 2,3,5,6-tetramethyl pyridine
发明人：KULKARNI SHIVANAND JANARDAN; RAGHAVAN KONDAPURAM VIJAYA; NAGABANDI SRINIVAS; VIPPAGUNTA RADHA RANI
权利人:COUNCIL SCIENT IND RES
摘要:The present invention provides a process for synthesis of tri- and tetra-alkylated pyridines (i.e. collidines) in high yields by reacting methyl ethyl ketone with formaldehyde in presence of ammonia in gas phase in the presence of a zeolite catalyst which comprises of silica-alumina with at least one metal ion and/or metal selected from the group consisting of lanthanum, lead, manganese, iron, copper and cobalt. This process provides eco-friendly, more economical and shape-selective heterogeneous method.

专利号:US-3637843-A
优先权日:1967-11-24
标题 :Synthesis of dicyanoformamides having an aromatic organic moiety
发明人：PATTON TAD L
权利人:EXXON RESEARCH ENGINEERING CO
摘要:DICYANOFORMAMIDES HAVING AROMATIC MOIETIES AS NOVEL COMPOSITION OF MATTER ARE PREPARED BY THE REACTION OF A DIISOCYANATE HAVING AN AROMATIC MOIETY WITH TWO (2) MOLES OF HYDROGEN CYANIDE IN THE PRESENCE OF A CATALYST WHICH WILL NOT PROMOTE FURTHER POLYMERIZATION.

专利号:US-3950416-A
优先权日:1967-11-24
标题 :Synthesis of dicyanoformamides
发明人：PATTON TAD L
权利人:EXXON RESEARCH ENGINEERING CO
摘要:Dicyanoformamides having aromatic moieties as novel composition of matter are prepared by the reaction of a diisocyanate having an aromatic moiety with two (2) moles of hydrogen cyanide in the presence of a specially defined, hindered catalyst which will not promote further polymerization.

专利号:US-8193392-B2
优先权日:2005-07-29
标 题:Method for enantioselective synthesis of phosphorus-stereogenic phosphines
发明人：SCRIBAN CORINA; GLUECK DAVID S
权利人:SCRIBAN CORINA; GLUECK DAVID S; DARTMOUTH COLLEGE
摘要:The present invention relates to a process for preparing an enantioenriched phosphorus-stereogenic, tertiary phosphine. Secondary phosphines are contacted with an alkyl halide and base in the presence of a chiral metal catalyst thereby producing the enantioenriched phosphorus-stereogenic, tertiary phosphine for subsequent use in homogeneous catalysis reactions.

专利号:US-7002006-B2
优先权日:2003-02-12
标 题:Protection of nucleosides
发明人：SONG QUANLAI; ROSS BRUCE S
权利人:ISIS PHARMACEUTICALS INC
摘要:A process of manufacturing protected nucleosides comprises reacting a nucleoside with a protecting reagent in the presence of a regioselective activator to produce a regioselectively protected nucleoside. In some embodiments of the inventive method, an optionally substituted trityl or optionally substituted pixyl group is selectively added to the 5'-O-position of a nucleoside in the presence of lutidine as activator or activator/solvent. The inventive method results in improved selectivity of the 5'-O-position over the 3'-O-position, thereby improving overall product yield and purity, and permitting simplified purification protocols, in some cases obviating the need for chromatography to produce a purified protected nucleoside suitable for automated synthesis of oligonucleotides, such as primers, probes and antisense molecules.

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合成参考文献


参考文献:10.1007/s40242-024-4129-y
摘要:Ma S, Tang Z. Supported Recyclable Metal-free Frustrated Lewis Pair Catalyst for Catalytic Hydrogenation of Substituted Pyridines to Piperidines. Chem. Res. Chin. Univ. 2024 Jul 15;40(4):682–9. doi: 10.1007/s40242-024-4129-y.
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