CAS: 80-78-4; Solanidine

该化合物是一种主要存在于Solanaceae家族植物(如土豆和番茄)中的血清藻类,是一种白晶状化合物,分子配方为C27H43NO. Solanidine以其作为其他藻类生物合成的前体的作用而著称,包括索拉宁和查科尼,它们是在绿色或血质土豆中发现的有毒化合物.该物质呈现一种以类固醇脊椎为特征的复杂结构,有助于其生物活动.Solanidine由于可能对人类健康产生影响,包括可能在调制胆固醇水平及其抗炎特性方面发挥作用,因此对药理学产生了兴趣.然而,必须指出,索拉尼丁酒在高浓度中具有毒性,而且其消费应该谨慎对待.与许多藻类一样,索拉尼丁的安全特征和治疗潜力仍然是医药化学和毒理学领域研究的主题.

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上下游产品

2)-O-4)>-β-D-glucopyranosidesolanidine 3-O-α-L-rhamnopyranosyl-(1*2)-O-β-D-glucopyranosyl-(1*4)-β-D-glucopyranoside 2)-β-D-glucopyranosidesolanidine 3-O-α-L-rhamnopyranosyl-(1-2)-β-D-glucopyranoside 30H47NO5SC30H47NO5S α-chaconine3β(p-toluenesulfonyloxy)-22αH,25βH-solanid-5-en-3-ol 3α,5-cyclo-5α,22αH,25βH-solanidan-6β-ol solanidine β-D-galactopyranoside demissidine

合成工艺路线路线简述

    📜Beta-查茄碱置于hesperidinase体系中,用 溶剂黄146 作为反应溶剂,化学反应 24.0H,反应生成 五氟硝基苯
    参考文献:Basic Steroid Saponins From Aerial Parts Of Fritillaria Thunbergii
    标题:Basic Steroid Saponins From Aerial Parts Of Fritillaria Thunbergii
    摘要:
    DOI:10.1016/0031-9422(82)80040-X

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    专利信息


    专利号:US-2009012013-A9
    优先权日:2003-07-08
    标题 :Steroid modified solatrioses
    发明人：LAWSON CHRISTOPHER J; WEYMOUTH-WILSON ALEXANDER C
    权利人:LAWSON CHRISTOPHER J; WEYMOUTH-WILSON ALEXANDER C
    摘要:The invention pertains to steroid modified solatrioses and the synthesis thereof as well as to intermediate compounds useful for the synthesis of the steroid modified solatrioses.

    专利号:EP-1654271-B1
    优先权日:2003-07-08
    标题:Steroid modified solatrioses
    发明人：LAWSON CHRISTOPHER JOHN; WEYMOUTH-WILSON ALEXANDER CHARLES
    权利人:GLYCOMED SCIENCES LTD
    摘要:The present invention relates to steroid modified chacotrioses and the synthesis thereof as well as to intermediate compounds useful for the synthesis of the steroid modified chacotrioses and solatrioses. Moreover, the present inventions relates to a method for the preparation of steroid-modified solatrioses.

    专利号:EP-3137618-A1
    优先权日:2014-04-29
    标 题 :Improved methods for making and using polynucleotide sequences in the synthesis of alkaloid compounds

    专利号:YU-61594-A
    优先权日:1994-10-21
    标 题:OBTAINING NEW SOLADIN AND 16-DEHYDROPREGNAN-20-O DERIVATIVES FOR THE SYNTHESIS OF STEROID HORMONES

    专利号:US-2017058305-A1
    优先权日:2014-04-29
    标 题:Improved Methods For Making and Using Polynucleotide Sequences in the Synthesis of Alkaloid Compounds

    专利号:US-2021198706-A1
    优先权日:2014-04-29
    标题 :Methods For Making and Using Polynucleotide Sequences in the Synthesis of Alkaloid Compounds

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    合成参考文献


    参考文献:10.1023/b:plan.0000028775.58537.fe
    摘要:Gachon C, Baltz R, Saindrenan P. Over-expression of a scopoletin glucosyltransferase in Nicotiana tabacum leads to precocious lesion formation during the hypersensitive response to tobacco mosaic virus but does not affect virus resistance. Plant Mol Biol. 2004 Jan;54(1):137–46. doi: 10.1023/b:plan.0000028775.58537.fe.
    参考文献:10.1007/s00122-008-0745-z
    摘要:Sørensen KK, Kirk HG, Olsson K, Labouriau R, Christiansen J. A major QTL and an SSR marker associated with glycoalkaloid content in potato tubers from Solanum tuberosum × S. sparsipilum located on chromosome I. Theoretical and Applied Genetics. 2008 Mar 29;117(1):1–9. doi: 10.1007/s00122-008-0745-z.
    参考文献:10.1007/s10886-014-0447-8
    摘要:Altesor P, García Á, Font E, Rodríguez-Haralambides A, Vilaró F, Oesterheld M, Soler R, González A. Glycoalkaloids of Wild and Cultivated Solanum: Effects on Specialist and Generalist Insect Herbivores. Journal of Chemical Ecology. 2014 May 27;40(6):599–608. doi: 10.1007/s10886-014-0447-8.
    参考文献:10.1186/s12906-018-2208-7
    摘要:Burger T, Mokoka T, Fouché G, Steenkamp P, Steenkamp V, Cordier W. Solamargine, a bioactive steroidal alkaloid isolated from Solanum aculeastrum induces non-selective cytotoxicity and P-glycoprotein inhibition. BMC Complementary Medicine and Therapies. 2018 May 02;18(1):137. doi: 10.1186/s12906-018-2208-7.
    参考文献:10.1007/s11248-018-0075-0
    摘要:Rahnama H, Moradi AB, Mirrokni SH, Moradi F, Shams MR, Fotokian MH. Comparative compositional analysis of transgenic potato resistant to potato tuber moth (PTM) and its non-transformed counterpart. Transgenic Res. 2018 Jun;27(3):301–13. doi: 10.1007/s11248-018-0075-0.
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