CAS: 74472-46-1; 2,3,3',5,5',6-Hexachloro-1,1'-Biphenyl

该化合物是多氯联苯(PCB)家族的成员,该家族由不同程度氯化的合成有机化学品组成,其特性是:多氯联苯165含有多种氯原子,影响其物理和化学特性;一般而言,这种物质无色于浅黄色固体或粘粘液,取决于其配方和温度;多氯联苯因其稳定性,耐降解性和疏水性而闻名,使其在环境中具有持久性;多氯联苯165与其他多氯联苯一样,被用于各种工业用途,包括电器设备,热传输液以及油漆和密封剂中的添加剂;然而,由于其毒性,生物累积潜力和对环境的不利影响,多氯联苯在许多国家被广泛禁止或限制;多氯联苯165被归类为可能的人类致癌物,接触可能导致一系列健康问题,包括内分泌干扰和免疫系统影响;妥善处理和处置对于减轻与该化学品有关的风险至关重要.

英文名称2,3,3',5,5',6-Hexachloro-1,1'-Biphenyl
中文名称2,3,3',5,5',6-六氯-1,1'-联苯
IUPAC名称1,2,4,5-tetrachloro-3-(3,5-dichlorophenyl)benzene
其它别名2,3,3',5,5',6-六氯联苯; 2,3,3',5,5',6-Hexachlorobiphenyl
CAS编号74472-46-1
MFCD编号:MFCD00674478
FDA UNII编号:75F87H98QU
分子式:C12H4Cl6分子量:360.88
产品CID: 1734790
产品分类有机原料→分子砌块→芳环类化合物→苯类化合物

相似结构搜索
产品信息参考;;;;
InChIKey: ZEATXTCWXKQPHO-UHFFFAOYSA-N
1S/C12H4Cl6/c13-6-1-5(2-7(14)3-6)10-11(17)8(15)4-9(16)12(10)18/h1-4H
计算化学: 氢键受体数*氢键供体数*可旋转键数1.0

MSDS等安全信息

GHS符号GHS07
警示词Warning
危险描述H302-H315-H319-H335
防范说明P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
安全声明The mechanism of action varies with the specific PCB. Dioxin-like PCBs bind to the aryl hydrocarbon receptor, which disrupts cell function by altering the transcription of genes, mainly be inducing the expression of hepatic Phase I and Phase II enzymes, especially of the cytochrome P450 family. Most of the toxic effects of PCBs are believed to be results of Ah receptor binding. Other PBCs are believed to interfere with calcium channels and/or change brain dopamine levels. PCBs can also cause endocrine disurption by altering the production of thyroid hormones and binding to estrogen receptors, which can stimulate the growth of certain cancer cells and produce other estrogenic effects, such as reproductive dysfunction. They will bioaccumulate by binding to receptor proteins such as uteroglobin. (A3, A4, A30, A66)

上下游产品

1,2,4,5-Tetrachloro-3-iodobenzene 3,5-dichloroiodobenzene 2,3,5,6-tetrachloroaniline 1,3-Dichlorobenzene

合成工艺路线路线简述

📜2,3,5,6-四氯苯胺,1,3-二氯苯置于亚硝酸异戊酯体系中,化学反应生成 2,3,3',5,5',6-六氯联苯
参考文献:Physical,Spectral And Chromatographic Properties Of All 209 Individual Pcb Congeners
标题:Physical,Spectral And Chromatographic Properties Of All 209 Individual Pcb Congeners
摘要:Physical,Spectral And Chromatographic Data For All 209 Individual Pcb Congeners Is Presented. The Individual Congeners Were Synthesized And Then Isolated And Purified. Recent Emphasis On The Source Of The Toxicity Of Commercial Pcb Formulations Has Increased The Need For A Complete Set Of The Pcb Congeners. Through The Use Of Two Capillary Gc Columns: 40% octadecyl/ 15% Phenyl Methyl Siloxane And 50% Phenyl Methyl Siloxane,It Was Possible To Separate 201 Pcb Congeners With Only Four Unresolved Pairs. The Data Compiled In This Study For All 209 Congeners Will Aid In The Identification Of Selected Individual Components Of These Environmental Pollutants. The Use Of This Data Also Presents The Opportunity For The Improved Quantification Of The Commercial Pcb Formulations.
DOI:10.1016/0045-6535(95)00140-4