CAS: 71-81-8; 4-Amino-N,N-Diisopropyl-N-Methyl-4-Oxo-3,3-Diphenylbutan-1-Aminium Iodide

上下游产品

4-diisopropylamino-2,2-diphenyl-butyric acid amide methyl iodide 4-diisopropylamino-2,2-diphenyl-butyronitrile

📜4-[双(异丙基)氨基]-2,2-二苯基丁腈置于硫酸,异丙醇体系中,化学反应生成 异丙碘胺
参考文献:De1003744
标题:De1003744

专利信息

专利号:US-2008300418-A1
优先权日:2004-11-08
标 题:Synthesis of Cardiolipin Analogues and Uses Thereof
发明人：AHMAD MOGHIS U; UKKALAM MURALI K; ALI SHOUKATH M; AHMAD IMRAN
权利人:AHMAD MOGHIS U; UKKALAM MURALI K; ALI SHOUKATH M; AHMAD IMRAN
摘要:The invention provides novel synthetic methodologies for preparing cardiolipin, migrated caridiolipin (1,2-positional isomer of cardiolipin) and their analogues having varying fatty acids and/or alkyl chains with varying length and degrees of saturation/unsaturation. The method comprises (a) reacting an optically pure 1,2-O-dialkyl-sn-glycerol or 1,2-O-dialkyl-sn-glycerol with one or more phosphoramidite reagent(s), wherein a phosphite triester is produced; (b) coupling the product of (a) with glycerol, wherein a protected cardiolipin is produced; and (c) deprotecting the protected cardiolipin, such that cardiolipin is prepared. The cardiolipins and analogues thereof, prepared by the present methods, can be incorporated into liposomes, which can also include active agents such as hydrophobic or hydrophilic drugs, antisense nucleotides or diagnostic agents. Such liposomes can be used to treat diseases or can be used in diagnostic and/or analytical assays.

专利号:US-2006078560-A1
优先权日:2003-06-23
标 题 :Method of inducing apoptosis and inhibiting cardiolipin synthesis
发明人：JAMIL HARIS; AHMAD MOGHIS U; AHMAD IMRAN
权利人:NEOPHARM INC
摘要:The present invention provides a method for inducing apoptosis within a cell by exposing the cell to an inhibitor of cardiolipin synthesis under conditions sufficient to induce apoptosis within the cell. The method can be used to investigate or treat disorders such as cancer, obesity, and cardiovascular disorders. The invention also provides a pharmaceutical composition including an inhibitor of cardiolipin synthesis and a liposomal carrier.

专利号:US-2008286351-A1
优先权日:2004-06-29
标 题:Pegylated Cardiolipin Analogs, Methods of Synthesis, and Uses Thereof
发明人：AHMAD MOGHIS U; UKKALAM MURALI K; ALI SHOUKATH M; AHMAD IMRAN
权利人:AHMAD MOGHIS U; UKKALAM MURALI K; ALI SHOUKATH M; AHMAD IMRAN
摘要:The invention provides synthetic methods for PEGylated cardiolipins with varying linkers. The methods can be employed to prepare PEGylated cardiolipin with different fatty acid and/or alkyl chain length with or without unsaturation. The PEGylated cardiolipin, prepared by the present methods, can be incorporated into liposomes that can also include active agents such as hydrophilic or hydrophobic drugs for the treatment of human and animal diseases. In addition, the PEGylated cardiolipin can be incorporated into liposomes that include compounds for therapeutic and diagnostic imaging. The use of such liposomes with PEGylated cardiolipin prolongs the period of liposomal circulation without disrupting the lipid bilayer.

专利号:US-2005266068-A1
优先权日:2002-05-24
标题 :Cardiolipin molecules and methods of synthesis
发明人：AHMAD MOGHIS U; UKKALAM MURALI K; AHMAD IMRAN
权利人:NEOPHARM INC
摘要:The invention provides new synthetic routes for cardiolipin with different fatty acids and/or alkyl chains with varying chain length and also with or without unsaturation, particularly a short-chain cardiolipin. The methods comprise reacting a 1,2-O-sn-diacyl/1,2-O-sn-dialkyl glycerol or a 2-O-protected glycerol, with a phosphoramidite reagent or a phosphate triester to produce a protected cardiolipin, which is deprotected to prepare the short chain cardiolipin. The reaction schemes can be used to generate new variants of cardiolipin. The cardiolipin prepared by the present methods can be incorporated into liposomes, which can also include active agents such as hydrophobic or hydrophilic drugs. Such liposomes can be used to treat diseases or in diagnostic and/or analytical assays. Liposomes can also include ligands for targeting a particular cell type or specific tissue.

专利号:US-8691793-B2
优先权日:2003-12-04
标题 :Modified macromolecules and associated methods of synthesis and use
发明人：PRESTWICH GLENN D; SHU XIAO ZHENG; LIU YANCHUN
权利人:PRESTWICH GLENN D; SHU XIAO ZHENG; LIU YANCHUN; UNIV UTAH RES FOUND
摘要:Described herein are compounds such as macromolecules that have been modified in order to facilitate crosslinking and methods of making and using thereof.

专利号:EP-1930323-A1
优先权日:2004-03-11
标 题:Biphenyl compounds useful in the synthesis of muscarinic receptor antagonists