CAS: 6937-03-7; Methyl 2-Aminoisonicotinate

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639091-75-1 105250-17-7 13362-28-2

上下游产品

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异烟酸甲酯置于三氟乙酸体系中,用 氯仿 作为反应溶剂,化学反应 0.5H,反应生成 2-氨基异烟酸甲酯
参考文献:Design Of Potent Bisphosphonate Inhibitors Of The Human Farnesyl Pyrophosphate Synthase Via Targeted Interactions With The Active Site 'capping' Phenyls
标题:Design Of Potent Bisphosphonate Inhibitors Of The Human Farnesyl Pyrophosphate Synthase Via Targeted Interactions With The Active Site 'capping' Phenyls
摘要:Nitrogen-Containing Bisphosphonates (N-Bps) Are Potent Active Site Inhibitors Of The Human Farnesyl Pyrophosphate Synthase (Hfpps) And Valuable Human Therapeutics For The Treatment Of Bone-Related Malignancies. N-Bps Are Also Useful In Combination Chemotherapy For Patients With Breast,Prostate And Multiple Myeloma Cancers. A Structure-Based Approach Was Employed In Order To Design Inhibitors That Exhibit Higher Lipophilicity And Better occupancy For The Gpp Sub-Pocket Of Hfpps Than The Current Therapeutic Drugs. These Novel Analogs Were Designed To Bind Deeper Into The Gpp Sub-Pocket By Displacing The Side Chains Of The 'Capping' Residue Phe 113 And Engaging In Favorable P-Interactions With The Side Chain Of Phe112. (C) 2012 Elsevier Ltd. All Rights Reserved.
DOI:10.1016/j.Bmc.2012.07.019

专利信息

专利号:US-8772301-B2
优先权日:2009-12-18
标题 :Compounds for treating disorders mediated by metabotropic glutamate receptor 5, and methods of use thereof
发明人：HARDY LARRY WENDELL; HEFFERNAN MICHELE L R; WU FRANK XINHE; SPEAR KERRY L; SARASWAT LAKSHMI D
权利人:HARDY LARRY WENDELL; HEFFERNAN MICHELE L R; WU FRANK XINHE; SPEAR KERRY L; SARASWAT LAKSHMI D; SUNOVION PHARMACEUTICALS INC
摘要:Provided herein are compounds and methods of synthesis thereof. The compounds set forth herein are useful for the treatment, prevention, and/or management of various disorders, such as neurological disorders, neurodegenerative disorders, neuropsychiatric disorders, disorders of cognition, learning or memory, gastrointestinal disorders, lower urinary tract disorder, and cancer. Compounds set forth herein modulate the activity of metabotropic glutamate receptor 5 (mGluR5) in the central nervous system or the periphery. Pharmaceutical formulations containing the compounds and their methods of use are also provided herein.

专利号:WO-2022213975-A1
优先权日:2021-04-08
标题:Compounds targeting y220c mutant of p53
发明人：LI SUJING; LI AMIN; ZHENG QIAN; Dang Chaojie; FAN XINRUI; LONG WEI; WANG YANPING
权利人:JACOBIO PHARMACEUTICALS CO LTD
摘要:Provided are compounds of formula (I) which can bind to p53 mutant and restore its ability to bind DNA and activate downstream effects involved in tumor suppression. Also provided are the synthesis processes and use of the compounds.

专利号:US-8518952-B2
优先权日:2008-08-06
标题 :6 substituted 2-heterocyclylamino pyrazine compounds as CHK-1 inhibitors
发明人：BRAGANZA JOHN FREDERICK; COLLINS MICHAEL RAYMOND; KATH JOHN CHARLES; NINKOVIC SACHA; LI HUI; RICHTER DANIEL TYLER
权利人:BRAGANZA JOHN FREDERICK; COLLINS MICHAEL RAYMOND; KATH JOHN CHARLES; NINKOVIC SACHA; LI HUI; RICHTER DANIEL TYLER; PFIZER
摘要:The present invention is directed to compounds of formula (I), n nand pharmaceutically acceptable salts thereof, their synthesis, and their use as CHK-1 inhibitors.

专利号:IT-8224576-A1
优先权日:1982-12-03
标题 :New derivatives of aminopyridincarboxylic acids, their synthesis methods and pharmaceutical compositions containing them