CAS: 68104-63-2; 4-(Piperazin-1-yl)Benzonitrile

上下游产品

CAS号110-85-0 哌嗪 | CAS号623-03-0 对氯苯腈 | CAS号1194-02-1 对氟苯腈 | CAS号186650-98-6 1-B°C-4-(4-氰基苯基)哌嗪 | CAS号821-48-7 二(2-氯乙基)胺盐酸盐 | CAS号873-74-5 对氨基苯腈 | CAS号34334-28-6 4-(4-甲基-1-哌嗪基)苯腈 | CAS号197638-76-9 4-(4-乙基哌嗪-1-基)苯甲醛 | CAS号186650-98-6 1-B°C-4-(4-氰基苯基)哌嗪 | CAS号163210-97-7 4-(哌嗪-1-基)苯甲酸甲酯 | CAS号27913-99-1 4-(4-甲基哌嗪)苯甲醛 | CAS号116290-73-4 4-(1-哌嗪基)苯甲酰胺

📜对氟苯腈置于potassium Carbonate,三氟乙酸体系中,用 二氯甲烷,二甲基亚砜 作为反应溶剂,化学反应 5.0H,反应生成 4-哌嗪基苯甲腈
参考文献:还原的亲脂性咪唑并[1,2-A]吡啶-3-甲酰胺衍生物的合成及抗结核评价
标题:还原的亲脂性咪唑并[1,2-A]吡啶-3-甲酰胺衍生物的合成及抗结核评价
摘要:设计了一系列具有各种侧链的还原亲脂性n-苄基咪唑并[1,2-A]吡啶羧酰胺(ipas),并合成了新的抗结核药物.五个衍生物a2,A3,A4,B1和b9对药物敏感性结核分枝杆菌h37Rv菌株和两个临床分离的耐多药菌株表现出出色的体外活性(mic:<0.035μm),并且具有可接受的pk特性.发现带有环己基甲基哌嗪部分(与pbtz169相同的侧链)的化合物b1的auc0-∞和c Max明显更大 比q203和pbtz169更高,表明其有望成为未来抗结核药物发现的先导化合物.
DOI:10.1016/j.Ejmech.2018.12.071

专利信息

专利号:US-12180182-B2
优先权日:2021-12-01
标题 :(Di)amination of activated allene compounds, derivatives thereof, and methods for synthesis of the same
发明人：DAI MINGJI
权利人:PURDUE RESEARCH FOUNDATION
摘要:One-pot synthesis methods for producing amines from activated allenes and derivatives thereof are provided, as well as the compounds produced thereby.

专利号:US-2025136575-A1
优先权日:2021-12-01
标 题:(di)amination of activated allene compounds, derivatives thereof, and methods for synthesis of the same

专利号:US-8404670-B2
优先权日:2009-02-11
标题:Histamine H3 inverse agonists and antagonists and methods of use thereof
发明人：CHYTIL MILAN; ENGEL SHARON R; FANG QUN KEVIN; SPEAR KERRY L
权利人:CHYTIL MILAN; ENGEL SHARON R; FANG QUN KEVIN; SPEAR KERRY L; SUNOVION PHARMACEUTICALS INC
摘要:Provided herein are fused imidazolyl compounds, methods of synthesis, and methods of use thereof. The compounds provided herein are useful for the treatment, prevention, and/or management of various disorders, such as neurological disorders and metabolic disorders. Compounds provided herein inhibit the activity of histamine H3 receptors and modulate the release of various neurotransmitters, such as histamine, acetylcholine, norepinephrine, and dopamine (e.g. at the synapse). Pharmaceutical formulations containing the compounds and their methods of use are also provided herein.

专利号:US-2023174506-A1
优先权日:2021-12-01
标 题 :(di)amination of activated allene compounds, derivatives thereof, and methods for synthesis of the same

专利号:CN-107793362-B
优先权日:2016-08-30
标 题:Synthesis and application of phenyl pyridazinone derivative