CAS: 58749-23-8; (E)-3-(3,4-Dihydroxy-2-Methoxyphenyl)-1-(4-Hydroxyphenyl)Prop-2-En-1-One
该化合物是一种天然化合物,被归类为素,是一种类素,主要来自产卵植物根,甘基里西里沙硬质素,并展示了一系列生物活动.该化合物的特征是黄色晶状晶体外观,具有反映其复杂结构的分子式,典型的有多个芳香环和功能组.Licochalsone B以其抗炎,抗氧化剂和抗微生物特性而著称,使其在药理学和化妆学应用中都具有兴趣.此外,它还就其潜在的抗癌作用进行了研究,因为它可能抑制各种癌症细胞线的扩散.该化合物的行动机制往往涉及信号路径的调节和特定基因的表达.由于其生物活动的多样性,正在探索用于治疗用途的Licocolcamon B,特别是在皮肤学和肿瘤学领域.其安全性特征和功效仍然是自然化学学研究的主体.
- 英文名称(E)-3-(3,4-Dihydroxy-2-Methoxyphenyl)-1-(4-Hydroxyphenyl)Prop-2-En-1-One
- 中文名称甘草查尔酮B
- IUPAC名称(E)-3-(3,4-dihydroxy-2-methoxyphenyl)-1-(4-hydroxyphenyl)prop-2-en-1-one
- 其它别名Licochalcone B [mi]; Licochalconeb; Licochalcone-B; (2E)-3-(3,4-Dihydroxy-2-Methoxyphenyl)-1-(4-Hydroxyphenyl)-2-Propen-1-One; (2E)-3-(3,4-Dihydroxy-2-Methoxyphenyl)-1-(4-Hydroxyphenyl)Prop-2-En-1-
- CAS编号58749-23-8
- MFCD编号:MFCD20527294
- FDA UNII编号:G7383L14F6
- 分子式:C16H14O5分子量:286.28
- 产品CID: 1562518
- 产品分类生物化工 → 提取物
物理性质
MSDS等安全信息
上下游产品
CAS号2144-08-3 2,3,4-三羟基苯甲醛 | CAS号85699-02-1 (E)-3-(2-methox... | CAS号85699-00-9 1-[4-(methoxyme... | CAS号85698-99-3 2-hydroxy-3,4-b... | CAS号85699-01-0 2-hydroxy-3,4,4... | CAS号99-93-4 对羟基苯乙酮合成工艺路线路线简述
📜2,3,4-三羟基苯甲醛置于potassium Carbonate,N,N-二异丙基乙胺体系中,用 甲醇,乙醇,二氯甲烷,丙酮 作为反应溶剂,化学反应 36.84H,反应生成 甘草查尔酮b
参考文献:항염증 활성을 나타내는 신규 리코찰콘 유사체 화합물
标题:항염증 활성을 나타내는 신규 리코찰콘 유사체 화합물
摘要:利可查孔被认为具有多种生物活性.然而,大多数利可查孔表现出细胞毒性.具有共同取代基的苯环b的利可查孔b和d已成为改变苯环a结构的靶点.这些合成的利可查孔类似物(化合物1~6)在抑制no反应生成方面分别显示出9.94,4.72,10.1,4.85,2.37和4.95 μm的ic50值.
海关参考信息
- 2901210000-乙烯
2901220000-丙烯
2902500000-苯乙烯
2902600000-乙苯 - 💡 提示：海关信息按照顺序优先匹配，如需确认的海关信息，请参考相关资料。
- 详情请参考：📖 海关编码查询和海关进出口税则
专利信息
专利号:US-2007036742-A1
优先权日:2005-08-09
标题 :Methods and compositions for modulating hair growth or regrowth
发明人：ROUFS JAMES B; DUVEL LANE A; FAST DAVID J; GLYNN KELLY M
权利人:ACCESS BUSINESS GROUP INT LLC
摘要:The present invention relates to compositions and methods for modulating hair growth or regrowth. The compositions of the present invention comprise extracts of one or more of the following: Boswellia serrata, Undaria pinnatifida, green tea (e.g., Camellia sinensis ), shiso, Pureraria mirifica, luteolin (e.g. Perilla ocymoides leaf extract), astilbin, vitamin E, amentoflavone, tetrahydropiperine, licochalcone, astaxanthin, red clover, Brassica juncea, unfermented green rooibos, enzyme CoQ10, salvia, ximenynic acid, hops oleoresin, apple, soy, saw palmetto, or ellagic extract, or any derivative thereof. In particular, the compositions and methods of the present invention can be used to stimulate or increase hair growth and/or prevent or slow the loss of hair by having one or more of the following functions: (a) inhibiting synthesis of DHT; (b) inhibiting proteasomal activity; (c) inhibiting IL-1 activity; (d) increasing vascularization; (e) increasing expression of vascular endothelial growth factor; (f) increasing expression of keratinocyte growth factor; (g) inhibiting inflammation; or (h) acting as an antibacterial.
专利号:CN-107311936-A
优先权日:2017-02-24
标题 :A cyclization derivative of licochalcone A and phenformin with antitumor activity and its synthesis method
专利号:CN-107311937-A
优先权日:2016-12-31
标 题:A class of licochalcone A dihydroaminopyrimidine compounds with antitumor activity and its synthesis method
供应商参考报价(招募中)
品牌试剂参考报价(招募中)
📌 第三方产品分析报告
主要参考文献
1: Kang TH, Yoon G, Kang IA, Oh HN, Chae JI, Shim JH. Natural Compound Licochalcone B Induced Extrinsic and Intrinsic Apoptosis in Human Skin Melanoma (A375) and Squamous Cell Carcinoma (A431) Cells. Phytother Res. 2017 Dec;31(12):1858-1867. doi: 10.1002/ptr.5928. Epub 2017 Oct 13. pii: E1627. doi: 10.3390/molecules22101627. doi: 10.1016/j.phymed.2017.08.005. Epub 2017 Aug 7. doi: 10.1016/j.bmc.2017.08.018. Epub 2017 Aug 15. Erratum in: Bioorg Med Chem. 2018 Jun 11;:. doi: 10.1016/j.bmc.2017.05.009. Epub 2017 May 6. doi: 10.22038/ijbms.2017.8235.
7: Teng H, Chen M, Zou A, Jiang H, Han J, Sun L, Feng C, Liu J. Hepatoprotective effects of licochalcone B on carbon tetrachloride-induced liver toxicity in mice. Iran J Basic Med Sci. 2016 Aug;19(8):910-915.
8: Yu L, Ma J, Han J, Wang B, Chen X, Gao C, Li D, Zheng Q. Licochalcone B Arrests Cell Cycle Progression and Induces Apoptosis in Human Breast Cancer MCF-7 Cells. Recent Pat Anticancer Drug Discov. 2016;11(4):444-452. doi: 10.3892/ijo.2016.3365. Epub 2016 Feb 1. doi: 10.1016/j.cbi.2014.10.024. Epub 2014 Oct 29. doi: 10.1155/2014/134862. Epub 2014 Aug 21.
合成参考文献
参考文献:10.1016/j.bmc.2009.11.027
摘要:Kuroda M, Mimaki Y, Honda S, Tanaka H, Yokota S, Mae T. Phenolics from Glycyrrhiza glabra roots and their PPAR-gamma ligand-binding activity. Bioorg Med Chem. 2010 Jan 15;18(2):962–70. doi: 10.1016/j.bmc.2009.11.027.
参考文献:10.1016/j.jep.2021.114488
摘要:Xu F, Hou T, Shen A, Jin H, Xiao Y, Yu W, Li X, Wang J, Liu Y, Liang X. Mechanism deconvolution of Qing Fei Pai Du decoction for treatment of Coronavirus Disease 2019 (COVID-19) by label-free integrative pharmacology assays. Journal of Ethnopharmacology. 2021 Nov;280():114488. doi: 10.1016/j.jep.2021.114488.
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