CAS: 57658-36-3; 2-(5-Sulfanylidene-2H-Tetrazol-1-yl)Acetic Acid

上下游产品

CAS号61197-32-8 N,N-dimethyl-2-...

N,N-Dimethyl-2-(5-Thioxo-4,5-Dihydro-Tetrazol-1-yl)-Acetamide置于sodium Hydroxide体系中,化学反应生成 5-巯基-1H-四氮唑-1-乙酸
参考文献:7-[2-(2-Aminothiazol-4-yl)-2-(Syn)-Methoxyiminoacetamido] Cephalosporins
标题:7-[2-(2-Aminothiazol-4-yl)-2-(Syn)-Methoxyiminoacetamido] Cephalosporins
摘要:一种7-[2-(2-氨基噻唑-4-基)-2-(Syn)-甲氧基亚硝基乙酰胺基]头孢菌素衍生物的化学式如下:##str1##其中r.Sub.3为氢或亲核化合物的残基;r.Sub.2 Nh为可能被保护的氨基团,其药用盐或酯,发现对包括大肠杆菌,马尔色菌,雷特格氏变形杆菌,克雷伯氏菌和弗伦德氏细菌在内的广谱细菌具有出色的抗菌活性.因此,该化合物可用作治疗目的中的抗菌剂.

专利信息

专利号:EP-4424821-A1
优先权日:2023-03-01
标题:Enzymatic synthesis of odilorhabdin and related peptides/proteins comprising non-standard amino acid residues
权利人:MAX PLANCK GESELLSCHAFT
摘要:The present invention relates to a novel method of preparing a non-standard amino acid or a peptide/protein comprising a non-standard amino acid residue, as appropriate, wherein said amino acid residue is selected from 2,4-diamino-3-hydroxybutyrate, L-5-hydroxylysine, L-3-hydroxyarginine, 2,3-didehydroarginine by using enzymatic transformations. Accordingly, the present invention further relates to a method of preparing a peptide/protein comprising one or more non-standard amino acids selected from 2,4-diamino-3-hydroxybutyrate, L-5-hydroxylysine, L-3-hydroxyarginine and 2,3-didehydroarginine. The methods of the present invention are particularly useful in enzyme-assisted preparation of odilorhabdins and their derivatives. The present invention further relates to a polypeptide having 2,4-diaminobutyrate-3-hydroxylase activity and its use for catalyzing a hydroxylation at position 3 of 2,4-diaminobutyrate, to a polypeptide having having L-arginine 3-hydroxylase activity and its use for catalyzing a hydroxylation at position 5 of L-lysine, to a polypeptide having L-arginine 3-hydroxylase activity and its use for for catalyzing a hydroxylation at position 3 of L-arginine, and to a polypeptide having a deacylase activity, which is preferably capable of removing fatty acyl from the N-terminus of an odilorhabdin, and its use for catalyzing a deacylation, preferably for removing a fatty acyl from the N-terminus of an odilorhabdin.

专利号:US-4171438-A
优先权日:1975-07-23
标 题:0-2-Isocephem-4-carboxylic acid derivatives as antibacterial agents
发明人：DOUGLAS JAMES L; HORNING DONALD E; MORRIS LEESON R
权利人:BRISTOL MYERS CO
摘要:There is described the stereoselective total synthesis of novel DELTA 2,3-1,4-morpholine-2-carboxylic acids possessing a fused beta -lactam ring in the 1,6-position and carrying a substituent cis to carbon 5 in the 7-position of the fused ring system represented by the general formula I wherein X is acylamino and Z represents optionally substituted C1-C6 alkyl, aryl or aralkyl. Also included in the invention are compounds of the above formula in which the carboxyl group at the 2-position is protected as by an easily cleavable ester group and salts of both the free acids and carboxyl-protected compounds. The compounds are potent antibacterial agents.

专利号:US-4118566-A
优先权日:1975-07-23
标 题:Δ2,3 -1,4-Morpholine-2-carboxylic acid derivatives as antibacterial agents
发明人：HORNING DONALD E; MORRIS LEESON R; DOUGLAS JAMES L
权利人:BRISTOL MYERS CO
摘要:There is described the stereoselective total synthesis of novel DELTA 2,3-1,4-morpholine-2-carboxylic acids possessing a fused beta -lactam ring in the 1,6-position and carrying a substituent cis to carbon 5 in the 7-position of the fused ring system represented by the general formula I wherein X is amino, azido or acylamido and Z represents optionally substituted C1-C6 alkyl, aryl, aralkyl or heterocyclic. Also included in the invention are compounds of formula I in which the carboxyl group at the 2-position is protected as by an easily cleavable ester group and salts of both the free acids and carboxyl-protected compounds of formula I. The compounds of formula I are potent antibacterial agents or are of use as intermediates in the preparation of such antibacterial agents.

专利号:US-11371063-B2
优先权日:2014-07-11
标题:Microorganisms and methods for the production of butadiene using acetyl-coA
发明人：PHARKYA PRITI; BURGARD ANTHONY P; BURK MARK J
权利人:GENOMATICA INC
摘要:The invention provides non-naturally occurring microbial organisms containing butadiene or 2,4-pentadienoate pathways comprising at least one exogenous nucleic acid encoding a butadiene or 2,4-pentadienoate pathway enzyme expressed in a sufficient amount to produce butadiene or 2,4-pentadienoate. The organism can further contain a hydrogen synthesis pathway. The invention additionally provides methods of using such microbial organisms to produce butadiene or 2,4-pentadienoate by culturing a non-naturally occurring microbial organism containing butadiene or 2,4-pentadienoate pathways as described herein under conditions and for a sufficient period of time to produce butadiene or 2,4-pentadienoate. Hydrogen can be produced together with the production of butadiene or 2,4-pentadienoate.

专利号:TW-200304826-A
优先权日:2002-03-04
标题:Processes for the synthesis of chloroadenosine and methylthioadenosine

专利号:US-4943567-A
优先权日:1987-05-30
标题 :Cephalosporin compound and pharmaceutical composition thereof
发明人：NISHIZAWA SUSUMU; MURO HIROYUKI; KASAI MASAYASU; HATANO SATORU; KAMIYA SYOUZI; KAKEYA NOBUHARU; KITAO KAZUHIKO
权利人:KYOTO PHARMA IND
摘要:Cephalosporin compounds represented by the general formula (I): ##STR1## wherein R 1 and R 5 independently represent a hydrogen atom or a protective group for an amino group; R 2 represents an alkyl group or a cycloalkyl group; R 3 represents a hydrogen atom, a lower alkenyl group, an alkanoyloxymethyl group, a carbamoyloxymethyl group, a heterocyclic thiomethyl group or a heterocyclic methyl group; R 4 represents a hydrogen atom or an ester residue; and X represents CH or a nitrogen atom and pharmacologically acceptable addition salts thereof, intermediate compounds used in the synthesis process of these compounds, production methods of these compounds and pharmaceutical compositions containing these compounds. n Said compounds or addition salts thereof exhibit noticeable antibacterial activities even on Pseudomonas aeruginosa, on which known cephalosporin compounds do not exhibit antibacterial activities, and moreover, work well against ordinary Gram-positive bacteria and Gram-negative bacteria.