CAS: 550-24-3; 2,5-Dihydroxy-3-Undecylcyclohexa-2,5-Diene-1,4-Dione

该化合物是一种自然形成的化合物,被归类为苯丙酮衍生物,主要来自以传统药用著而闻名的Emberia 肋骨厂的水果,Emberin展示了一系列生物活动,包括抗氧化剂,抗炎和抗微生物特性,使其对药理研究感兴趣.该化合物的特点是分子配方,通常包括碳,氢和氧原子,有助于其结构特性.Emberin经常被研究其潜在的治疗用途,特别是在癌症治疗和代谢失调方面.此外,人们注意到,Emberin有能力调整各种生物化学途径,进一步提高其在医药化学中的重要性.其溶剂和环境条件的溶性与稳定性可能不同,而这些条件是其应用和研究中需要考虑的重要因素.总的来说,Embelin是天然产品化学和药物开发中的一种有价值的化合物.

结构式图片

欧盟法规

ECHA物质C&L通报REACH预注册

上下游产品

CAS号105-74-8 过氧化十二酰 | CAS号112-16-3 十二酰氯 | CAS号775350-90-8 2,5-bis-methyla... | CAS号850878-20-5 3-undecyl-benze... | CAS号56923-51-4 2-phenylamino-5... | CAS号143-07-7 月桂酸 | CAS号141-82-2 丙二酸 | CAS号144-62-7 草酸 | CAS号25575-65-9 2-oxo-Tetradeca... | CAS号64-18-6 甲酸 | CAS号88792-39-6 2,5-Cyclohexadi... | CAS号88792-40-9 2-bromo-3,6-dih... | CAS号88792-41-0 2,5-Cyclohexadi... | CAS号88792-42-1 (4-acetyloxy-5-... | CAS号93072-80-1 6-(4-chlorophen...

合成工艺路线路线简述

    📜月桂酰氯置于sodium Peroxide,水,溶剂黄146,Petroleum Ether体系中,化学反应生成 恩贝酸/恩贝灵
    参考文献:Fieser; Chamberlin,Journal Of The American Chemical Society,1948,Vol. 70,P. 74
    标题:Fieser; Chamberlin,Journal Of The American Chemical Society,1948,Vol. 70,P. 74

    海关参考信息

    专利信息


    专利号:US-12383579-B2
    优先权日:2018-04-23
    标 题 :Materials and methods of using an inhibitor of plasminogen activation to treat anastomotic leak
    发明人:ALVERDY JOHN C; ZABORINA OLGA Y; JACOBSON RICHARD A
    权利人:UNIV CHICAGO; UNIV RUSH MEDICAL CENTER
    摘要:Disclosed herein is the de novo synthesis of phosphorylated polyethylene glycol compounds with three defined ABA (hy-drophilic/-phobic/-philic) structures: ABA-PEG10k-Pi10, ABA-PEG16k-Pi14, and ABA-PEG20k-Pi20 and linear polymer PEG20k-Pi20 absent of hydrophobic block. The disclosure also provides materials and methods for treating or reducing the risk or likelihood of developing, anastomotic leak or other microbe-mediated disorders by administering a therapeutically effective amount of a plasminogen inhibitor such as tranexamic acid and/or a phosphate-loaded polymer.

    专利号:US-2017107577-A1
    优先权日:2014-03-11
    标题:Determining Cancer Aggressiveness, Prognosis and Responsiveness to Treatment
    发明人:AL-EJEH FARES
    权利人:THE COUNCIL OF THE QUEENSLAND INST OF MEDICAL RES
    摘要:The invention provides methods of determining the aggressiveness, prognosis and response to therapy for particular cancers, which include comparing the expression levels of one or a plurality of differentially expressed genes from one or more 5 functional metagenes, including a Carbohydrate/Lipid Metabolism metagene, a Cell Signalling metagene, a Cellular Development metagene, a Cellular Growth metagene, a Chromosome Segregation metagene, a DNA Replication/Recombination metagene, an Immune system metagene, a Metabolic Disease metagene, a Nucleic Acid Metabolism metagene, a Post-Translational Modification metagene, a Protein 10 Synthesis/Modification metagene and a Multiple Networks metagene. The method disclosed herein may be particularly suitable as a companion diagnostic for cancer therapies.

    专利号:US-7674934-B2
    优先权日:2004-08-05
    标题:Stabilizers for use in NVP synthesis
    发明人:HOEFER FRANK; BRAND ALEXANDRA; BOETTCHER ARND; BAUMANN KATRIN; VOGELSANG REGINA
    权利人:BASF AG
    摘要:A process for preparing N-alkenyl compounds by reacting the corresponding NH compounds with alkynes in the liquid phase in the presence of a catalyst, wherein the reaction is carried out in the presence of at least one stabilizer, and the use of stabilizers for increasing the selectivity in a process for preparing N-alkenyl compounds by reacting the corresponding NH compounds with alkynes in the liquid phase in the presence of a catalyst.

    专利号:US-2024208898-A1
    优先权日:2021-03-25
    标 题 :Enamine n-oxides: synthesis and application to hypoxia-responsive prodrugs and imaging agents
    发明人:KIM JUSTIN; KANG DAHYE; CHEUNG SHELDON T
    权利人:DANA FARBER CANCER INST INC
    摘要:Disclosed are compounds and pharmaceutically acceptable salts and stereoisomers thereof that are suitable for diagnosis and the treatment of diseases and disorders characterized by, associate with or which exhibit tissue hypoxia, such as, for example, solid tumors. Also disclosed are pharmaceutical compositions containing same, and methods of making and using the compounds.

    专利号:JP-2024512568-A
    优先权日:2021-03-25
    标 题:Enamine N-oxide: synthesis and application of hypoxia-responsive prodrugs and contrast agents

    专利号:CN-114835623-B
    优先权日:2022-06-08
    标题:A New Synthesis Method of Amygaceae Alkaloid (±) Mesembrine

    供应商参考报价(招募中)

    品牌试剂参考报价(招募中)

    📌 第三方产品分析报告

    ✅ COA系统入驻 | 共享模式

    主要参考文献


    1: Danquah M. Embelin and Its Derivatives: Design, Synthesis, and Potential Delivery Systems for Cancer Therapy. Pharmaceuticals (Basel). 2022 Sep 9;15(9):1131. doi: 10.3390/ph15091131.
    2: Lu H, Wang J, Wang Y, Qiao L, Zhou Y. Embelin and Its Role in Chronic Diseases. Adv Exp Med Biol. 2016;928:397-418. doi: 10.1007/978-3-319-41334-1_16. 36(12):3054-3068. doi: 10.1080/14786419.2021.1955361. Epub 2021 Jul 26. 36(2):e22950. doi: 10.1002/jbt.22950. Epub 2021 Nov 29. 20(5):396-407. doi: 10.2174/1389557519666191015202723. 23(3):427-44. doi: 10.1517/13543784.2014.867016. Epub 2014 Jan 8. 10(8):961-976. doi: 10.4155/fmc-2017-0198. Epub 2018 Apr 5. 23(3):621. doi: 10.3390/molecules23030621.
    9: Zappavigna S, Cossu AM, Grimaldi A, Bocchetti M, Ferraro GA, Nicoletti GF, Filosa R, Caraglia M. Anti-Inflammatory Drugs as Anticancer Agents. Int J Mol Sci. 2020 Apr 9;21(7):2605. doi: 10.3390/ijms21072605.

    合成参考文献


    参考文献:10.1007/s12640-011-9258-7
    摘要:Thippeswamy BS, Nagakannan P, Shivasharan BD, Mahendran S, Veerapur VP, Badami S. Protective effect of embelin from Embelia ribes Burm. against transient global ischemia-induced brain damage in rats. Neurotox Res. 2011 Nov;20(4):379–86. doi: 10.1007/s12640-011-9258-7.
    📝 需求与反馈
    尽可能描述清楚需求与问题信息
    ×

    通知