📜月桂酰氯置于sodium Peroxide,水,溶剂黄146,Petroleum Ether体系中,化学反应生成 恩贝酸/恩贝灵 参考文献:Fieser; Chamberlin,Journal Of The American Chemical Society,1948,Vol. 70,P. 74 标题:Fieser; Chamberlin,Journal Of The American Chemical Society,1948,Vol. 70,P. 74
专利号:US-12383579-B2 优先权日:2018-04-23 标 题 :Materials and methods of using an inhibitor of plasminogen activation to treat anastomotic leak 发明人:ALVERDY JOHN C; ZABORINA OLGA Y; JACOBSON RICHARD A 权利人:UNIV CHICAGO; UNIV RUSH MEDICAL CENTER 摘要:Disclosed herein is the de novo synthesis of phosphorylated polyethylene glycol compounds with three defined ABA (hy-drophilic/-phobic/-philic) structures: ABA-PEG10k-Pi10, ABA-PEG16k-Pi14, and ABA-PEG20k-Pi20 and linear polymer PEG20k-Pi20 absent of hydrophobic block. The disclosure also provides materials and methods for treating or reducing the risk or likelihood of developing, anastomotic leak or other microbe-mediated disorders by administering a therapeutically effective amount of a plasminogen inhibitor such as tranexamic acid and/or a phosphate-loaded polymer.
专利号:US-2017107577-A1 优先权日:2014-03-11 标题:Determining Cancer Aggressiveness, Prognosis and Responsiveness to Treatment 发明人:AL-EJEH FARES 权利人:THE COUNCIL OF THE QUEENSLAND INST OF MEDICAL RES 摘要:The invention provides methods of determining the aggressiveness, prognosis and response to therapy for particular cancers, which include comparing the expression levels of one or a plurality of differentially expressed genes from one or more 5 functional metagenes, including a Carbohydrate/Lipid Metabolism metagene, a Cell Signalling metagene, a Cellular Development metagene, a Cellular Growth metagene, a Chromosome Segregation metagene, a DNA Replication/Recombination metagene, an Immune system metagene, a Metabolic Disease metagene, a Nucleic Acid Metabolism metagene, a Post-Translational Modification metagene, a Protein 10 Synthesis/Modification metagene and a Multiple Networks metagene. The method disclosed herein may be particularly suitable as a companion diagnostic for cancer therapies.
专利号:US-7674934-B2 优先权日:2004-08-05 标题:Stabilizers for use in NVP synthesis 发明人:HOEFER FRANK; BRAND ALEXANDRA; BOETTCHER ARND; BAUMANN KATRIN; VOGELSANG REGINA 权利人:BASF AG 摘要:A process for preparing N-alkenyl compounds by reacting the corresponding NH compounds with alkynes in the liquid phase in the presence of a catalyst, wherein the reaction is carried out in the presence of at least one stabilizer, and the use of stabilizers for increasing the selectivity in a process for preparing N-alkenyl compounds by reacting the corresponding NH compounds with alkynes in the liquid phase in the presence of a catalyst.
专利号:US-2024208898-A1 优先权日:2021-03-25 标 题 :Enamine n-oxides: synthesis and application to hypoxia-responsive prodrugs and imaging agents 发明人:KIM JUSTIN; KANG DAHYE; CHEUNG SHELDON T 权利人:DANA FARBER CANCER INST INC 摘要:Disclosed are compounds and pharmaceutically acceptable salts and stereoisomers thereof that are suitable for diagnosis and the treatment of diseases and disorders characterized by, associate with or which exhibit tissue hypoxia, such as, for example, solid tumors. Also disclosed are pharmaceutical compositions containing same, and methods of making and using the compounds.
专利号:JP-2024512568-A 优先权日:2021-03-25 标 题:Enamine N-oxide: synthesis and application of hypoxia-responsive prodrugs and contrast agents
专利号:CN-114835623-B 优先权日:2022-06-08 标题:A New Synthesis Method of Amygaceae Alkaloid (±) Mesembrine
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合成参考文献
参考文献:10.1007/s12640-011-9258-7 摘要:Thippeswamy BS, Nagakannan P, Shivasharan BD, Mahendran S, Veerapur VP, Badami S. Protective effect of embelin from Embelia ribes Burm. against transient global ischemia-induced brain damage in rats. Neurotox Res. 2011 Nov;20(4):379–86. doi: 10.1007/s12640-011-9258-7.