CAS: 529-35-1; 5,6,7,8-Tetrahydro-1-Naphthol

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萘酚置于palladium On Activated Charcoal,氢气体系中,用 乙醇 作为反应溶剂,50.0 °C,8.11 Mpa 条件下,反应 8.0H,以95%的收率获得产物四氢萘酚
参考文献:H 4-萘衍生的轴向手性联芳基吡ido胺对α-酮酸的对映选择性仿生氨基转移
标题:H 4-萘衍生的轴向手性联芳基吡ido胺对α-酮酸的对映选择性仿生氨基转移
摘要:不对称仿生转氨反应是合成化学和生物学上重要的手性氨基酸和手性胺的极具吸引力的方法.手性吡ido胺/吡rid醛的开发是反应的关键.已经开发了基于h 4-萘基骨架的新的轴向手性联芳基吡ido胺.吡ido胺在α-酮酸的不对称仿生转氨反应中表现出非常好的对映选择性和高催化活性,可提供多种旋光性非天然氨基酸,产率为61-98%,Ee可达91%.
DOI:10.1016/j.Tetlet.2018.01.089

专利信息

专利号:US-10040752-B2
优先权日:2015-08-24
标 题 :Synthesis of levomethadone hydrochloride or dextromethadone hydrochloride and methods for use thereof
发明人：MKRTCHYAN GNEL; YAO QINGWEI
权利人:CODY LABORATORIES INC
摘要:Highly efficient methods for synthesis of levomethadone hydrochloride or dextromethadone hydrochloride are provided starting from D-alanine, or L-alanine, respectively, with retention of configuration. Methods for treating a subject are provided comprising administering a composition comprising an effective amount of levomethadone hydrochloride having not more than 10 ppm dextromethadone.

专利号:US-2004110228-A1
优先权日:2002-04-01
标 题:Combinatorial organic synthesis of unique biologically active compounds
发明人：MCALPINE SHELLI R; TAYLOR RACHEL E; BOLLA MEGAN L; SEGALL ANCA M
摘要:The invention provides a method for making a combinatorial library of cyclic compounds, such as Holliday junction-trapping compounds, comprising the steps of (a) obtaining a plurality of trimers according to the generic structure X 1- X 2- X 3 , wherein X 1 , X 2 and X 3 can be independently any naturally or nonnaturally occurring amino acids or peptidomimetics thereof; (b) optionally coupling a spacer S to the trimer at either end; (c) cyclizing two trimers or trimer-spacer conjugates in a head-to-tail orientation; thereby obtaining a combinatorial library of compounds, wherein the library does not include an unmodifed or naturally occurring Holliday Junction-trapping compounds. The invention additionally provides methods macrocyclic compounds that are synergimycin derivatives.

专利号:US-4758661-A
优先权日:1986-06-24
标题 :Chiral synthesis of (+)-trans-1a,2,3,4a,5,6-hexahydro-9-hydroxy-4-propyl-4H-naphth[1,2-b]-1,4-oxazine
发明人：MELILLO DAVID G; MATHRE DAVID J; LARSEN ROBERT D
权利人:MERCK & CO INC
摘要:(+)-trans-1a,2,3,4a,5,6-Hexahydro-9-hydroxy-4-propyl-4H-naphth[1,2-b]-1,4-oxazine is elaborated by a series of process steps that retain the enantiomeric purity of the starting material, D-aspartic acid. The product is a direct acting dopaminergic agent, useful in the treatment of Parkinson's disease.

专利号:WO-2023122754-A1
优先权日:2021-12-23
标 题 :Processes and intermediates for preparing gb13, gb22 and himgaline
发明人：LANDWEHR ELEANOR; SHENVI RYAN; BAKER MEGHAN; OGUMA TAKUYA
权利人:SCRIPPS RESEARCH INST
摘要:Provided herein are processes for the streamlined synthesis of Galbulimima alkaloids, such as himbadine, isolated from Galbulimima belgraveana and G. baccatta, trees endemic to the rainforests of Northern Australia and Papua New Guinea, as well as analogs thereof, such as GB13, GB16, GB22, and himgaline, and further including intermediates useful in the synthesis of these and related compounds.

专利号:US-2019002394-A1
优先权日:2015-08-24
标 题 :Synthesis of levomethadone hydrochloride or dextromethadone hydrochloride and methods for use thereof

专利号:US-2017057909-A1
优先权日:2015-08-24
标 题 :Synthesis of levomethadone hydrochloride or dextromethadone hydrochloride and methods for use thereof