专利号:US-2008311580-A1 优先权日:2004-03-09 标 题:Novel genes encoding proteins involved in proanthocyanidin synthesis 发明人:ABRAHAMS SHARON; ASHTON ANTHONY RICHARD; TANNER GREGORY JOHN; LARKIN PHILIP JOHN 权利人:COMMW SCIENT IND RES ORG 摘要:This inventions provides an isolated protein or polypeptide having activity in the synthesis of proanthocyanidin (PA) polymer from epicatechin or catechin in plants, and which is not naturally regulated by the TT2 or TT8 regulators, or a fragment comprising at least about 10 contiguous amino acids derived from said protein or polypeptide, particularly TDS1, TDS2, TDS3, TDS4, TDS5, or TDS6 protein, or fragment thereof. n Also provided are nucleic acid encoding such proteins or polypeptides; plant cells and plants containing and expressing such nucleic acids; antibodies that bind to such proteins or polypeptides; and related methods.
专利号:US-8318928-B2 优先权日:2008-12-15 标题 :Fused imidazole carboxamides as TRPV3 modulators 发明人:CHAUDHARI SACHIN SUNDARLAL; ABRAHAM THOMAS; KADAM ASHOK BHAUSAHEB; DHONE SACHIN VASANTRAO; KADAM SURESH MAHADEV; KHAIRATKAR-JOSHI NEELIMA; KATTIGE VIDYA GANAPATI 权利人:CHAUDHARI SACHIN SUNDARLAL; ABRAHAM THOMAS; KADAM ASHOK BHAUSAHEB; DHONE SACHIN VASANTRAO; KADAM SURESH MAHADEV; KHAIRATKAR-JOSHI NEELIMA; KATTIGE VIDYA GANAPATI; GLENMARK PHARMACEUTICALS SA 摘要:The present invention provides transient receptor potential vanilloid (TRPV) modulators of formula (I). In particular, compounds described herein are useful for treating or preventing diseases, conditions and/or disorders modulated by TRPV3. Also provided herein are processes for preparing compounds described herein, intermediates used in their synthesis, pharmaceutical compositions thereof, and methods for treating or preventing diseases, conditions and/or disorders modulated by TRPV3.
专利号:US-2011237659-A1 优先权日:2008-11-17 标题:Chromenone derivatives as trpv3 antagonists 发明人:CHAUDHARI SACHIN SUNDARLAL; THOMAS ABRAHAM; KADAM ASHOK BHAUSAHEB; DHONE SACHIN VASANTRAO; ADIK BHARAT GANGADHAR; KHAIRATKAR-JOSHI NEELIMA; KATTIGE VIDYA GANAPATI 权利人:GLENMARK PHARMACEUTICALS SA 摘要:The present invention provides transient receptor potential vanilloid (TRPV) modulators of formula (I). In particular, compounds described herein are useful for treating or preventing diseases, conditions and/or disorders modulated by TRPV3. Also provided herein are processes for preparing compounds described herein, intermediates used in their synthesis, pharmaceutical compositions thereof, and methods for treating or preventing diseases, conditions and/or disorders modulated by TRPV3.
专利号:EP-3925948-A1 优先权日:2019-04-26 标 题:Intermediate of eribulin, synthesis method therefor and use thereof
专利号:US-2022204523-A1 优先权日:2019-04-26 标 题 :Intermediate of eribulin and synthesis method and use thereof
专利号:WO-2020216034-A1 优先权日:2019-04-26 标 题:Intermediate of eribulin, synthesis method therefor and use thereof
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