CAS: 38861-78-8; 4'-Isobutylacetophenone

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CAS号538-93-2 异丁基苯 | CAS号75-36-5 乙酰氯 | CAS号15687-27-1 布洛芬 | CAS号40150-92-3 布洛芬杂质32 | CAS号108-24-7 乙酸酐 | CAS号84110-40-7 异丁基硼酸 | CAS号99-90-1 4-溴苯乙酮 | CAS号58901-83-0 3-methyl-3-[4-(... | CAS号59512-17-3 布洛芬杂质C | CAS号100319-40-2 1-乙基-4-异丁基苯 | CAS号40150-98-9 4-异丁基苯甲醛 | CAS号40150-92-3 布洛芬杂质32 | CAS号100319-40-2 1-乙基-4-异丁基苯 | CAS号38861-88-0 4-异丁基苯甲酸 | CAS号51146-57-7 (R)-布洛芬 | CAS号51146-56-6 (S)-(+)-布洛芬 | CAS号100-68-5 茴香硫醚 | CAS号30095-48-8 2-bromo-1-(4-is... | CAS号208944-55-2 3-氨基-5-(4-异丁基苯基... | CAS号66734-95-0 4-异丁基肉桂酸

异丁基苯 以98的收率获得产物4-异丁基苯乙酮
参考文献: Continuous Flow Synthesis Of Ibuprofen[fr] Synthèse En Continu D'Ibuprofène
标题: Continuous Flow Synthesis Of Ibuprofen[fr] Synthèse En Continu D'Ibuprofène
摘要:本公开涉及制备布洛芬,萘普生和其衍生物的方法.本公开还涉及由所披露方法制备的化合物.本摘要旨在作为特定领域搜索的扫描工具,并不意味着对本发明的限制.

专利信息

专利号:US-5248815-A
优先权日:1991-12-27
标 题 :Stereo-selective synthesis of 2-aryl-propionic acids of high optical purity by using chiral oxazolines
发明人：PARADIES HENRICH H
权利人:PARADIES HENRICH H
摘要:The present invention relates to a stereospecific chemical synthesis of optically pure enantiomers of 2-aryl-alkanoic acids, especially those of the biologically active (S)-aryl-propionic acids, in good chemical yields, useful for preparing large quantities thereof, and having a high optical purity.

专利号:US-11639326-B2
优先权日:2017-04-06
标 题 :Continuous flow synthesis of ibuprofen
发明人：COLLINS NATHAN; MALERICH JEREMIAH; SZETO JUDY; KOZOCAS JOSEPH A
权利人:STANFORD RES INST INT
摘要:This disclosure generally relates to methods of making ibuprofen, naproxen, and derivatives thereof. This disclosure also generally relates to compounds made by the disclosed methods. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.

专利号:US-4096177-A
优先权日:1974-04-11
标题:Process for the preparation of p. isobutyl-hydratropic
发明人：BAIOCCHI LEANDRO
权利人:BAIOCCHI LEANDRO
摘要:A process for the synthesis of Ibuprofen, p - isobutyl hydrotropic acid is described based upon the aromatization reaction which takes place when a dialkyl alpha -acetyl- alpha -[(5-methyl-3-oxo)-hexyl]- alpha '-methyl-succinate (II) is heated at temperatures of about 200 DEG with a strong acid, or a salt of a strong acid with an organic base.

专利号:WO-9313046-A1
优先权日:1991-12-27
标题:Stereo-selective synthesis of 2-aryl-propionic acids of high optical purity by using chiral oxazolines

专利号:WO-2007044270-A1
优先权日:2005-10-06
标 题:Process for producing high purity ketones by friedel-crafts acylation at low temperature
发明人：MANIMARAN THANIKAVELU; HARKINS ALVIN E
权利人:ALBEMARLE CORP; MANIMARAN THANIKAVELU; HARKINS ALVIN E
摘要:The present invention relates to improved conditions for the Friedel-Crafts acylation of alkylbenzenes and to application of these improved conditions to the synthesis of para-isobutyl acetophenone and ibuprofen. The reaction conditions include operating the reaction at a temperature below 0°C and typically below -10° C.

专利号:TW-I383984-B
优先权日:2005-05-25
标题:Synthesis of (R)-N-methylnaltrexone (METHYLNALTREXONE)